A5016301975- Glioma Diagnosis and Treatment
- Alzheimer's disease research and treatments
- Meningioma and schwannoma management
- Bone Tumor Diagnosis and Treatments
- Neurological Disease Mechanisms and Treatments
- Cancer, Hypoxia, and Metabolism
- Spider Taxonomy and Behavior Studies
- Genetics and Neurodevelopmental Disorders
- Chromatin Remodeling and Cancer
- Sarcoma Diagnosis and Treatment
- Pituitary Gland Disorders and Treatments
- Amino Acid Enzymes and Metabolism
- Medical Imaging Techniques and Applications
- Dementia and Cognitive Impairment Research
- Advanced MRI Techniques and Applications
- Neuroblastoma Research and Treatments
- Neurofibromatosis and Schwannoma Cases
- Ocular Oncology and Treatments
- Lymphoma Diagnosis and Treatment
- Parkinson's Disease Mechanisms and Treatments
- Metabolism and Genetic Disorders
- Protein Tyrosine Phosphatases
- Molecular Biology Techniques and Applications
- AI in cancer detection
- Traumatic Brain Injury and Neurovascular Disturbances
The University of Texas Southwestern Medical Center
2018-2024
Southwestern Medical Center
2020-2022
Adult brainstem gliomas are difficult to classify based on radiologic and histologic features. A K27M mutation in histone 3 has been described identify high-grade midline associated with a particularly unfavorable prognosis. While initially considered pediatric entity, it is now known that H3K27M-mutant occur all age groups, but they less well understood adults. We studied clinical, radiologic, pathologic features of 25 diagnosed at our institution between 1994 2017 subjects least 18 years...
Abstract Neurodegenerative pathologies such as Alzheimer disease neuropathologic change (ADNC), Lewy body (LBD), limbic-predominant age-related TDP-43 encephalopathy (LATE-NC), and cerebrovascular (CVD) frequently coexist, but little is known about the exact contribution of each pathology to cognitive decline dementia in subjects with mixed pathologies. We explored relative impact concurrent common rare neurodegenerative employing multivariate logistic regression analysis adjusted for age,...
High-grade gliomas likely remodel the metabolic machinery to meet increased demands for amino acids and nucleotides during rapid cell proliferation. Glycine, a non-essential acid intermediate of nucleotide biosynthesis, may increase with Non-invasive measurement glycine by magnetic resonance spectroscopy (MRS) was evaluated as an imaging biomarker assessment tumor aggressiveness.
Alzheimer's disease (AD) and primary age-related tauopathy (PART) both harbor 3R/4R hyperphosphorylated-tau (p-tau)-positive neurofibrillary tangles (NFTs) but differ in the spatial p-tau development hippocampus.
Chordoid meningioma is a morphological variant of designated as WHO grade 2. However, the recurrence rates varied widely in different case series, and to date, unifying molecular genetic signature has not been identified. Among 1897 meningiomas resected at our institution, we identified 12 primary chordoid from patients. Histologically, all cases had predominant (> 50%) morphology. Ten were otherwise 1, two also atypical. We performed DNA global methylation profile, copy number variation...
Abstract Glioblastoma (GBM), representing WHO grade IV astrocytoma, is a relatively common primary brain tumor in adults with an exceptionally dismal prognosis. With incidence rate of over 10 000 cases the United States annually, median survival ranges from 10–15 months IDH1/2-wildtype tumors and 24–31 IDH1/2-mutant tumors, further variation depending on factors such as age, MGMT methylation status, treatment regimen. We present cohort 4 patients, aged 37–60 at initial diagnosis, IDH1-mutant...
Pleomorphic xanthoastrocytoma (PXA) is a slow-growing neoplasm that predominantly affects the pediatric and young adult population. This has good prognosis, with median 10-year survival rate of 70%. The majority tumors are supratentorial arise in temporal lobe, while spinal extremely rare, only 8 reported cases. Molecular perturbations involving MAPK/ERK signaling pathway have been described PXAs. most common mutation BRAF V600E 60%–80% Other mechanisms activating this absence rare include...
Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune disease mediated by IgG1 or IgG3 antibodies to the GluN1 subunit of NMDAR, resulting in downregulation NMDARs. Early diagnosis, prompt reduction anti-NMDAR antibodies, and removal associated ovarian tumors when identified are important drivers prognosis. Immunohistochemical studies were carried out evaluate B cell, plasma T-cell infiltrates brain a 3-year-old patient with who failed show improvement after exchange...
Abstract Although Alzheimer disease neuropathologic change (ADNC) is the most common pathology underlying clinical dementia, presence of multiple comorbid neuropathologies increasingly being recognized as a major contributor to worldwide dementia burden. We analyzed 1051 subjects with specific combinations isolated and mixed pathologies conducted multivariate logistic regression analysis on cohort 4624 cases systematically explore independent cognitive contributions each pathology....
Identification of molecular genetic alterations has become an important part diagnosis and care patients with brain tumors. Comparisons immunohistochemistry (IHC) DNA sequencing techniques have suggested that IHC is useful for identifying surrogates mutations in gliomas; however, studies the efficacy are relatively few. Our aim was to compare our neuropathology laboratory a commercially available next-generation (NGS) platform, Tempus xT. We studied 212 immunohistochemically stained sections...
Abstract Background Although Alzheimer disease (AD) and primary age‐related tauopathy (PART) both harbor 3R/4R‐tau immunopositive Alzheimer‐type neurofibrillary degeneration, they differ in the spatial development of tangles (NFTs) hippocampus. PART displays an early predilection for degeneration CA2 subregion hippocampus, whereas AD typically develops NFTs entorhinal cortex CA1 initially (Figures 1‐2). Method Using Nanostring’s GeoMx™ Digital Spatial Profiling (DSP), we compared hippocampal...
Alzheimer's disease (AD), primary age-related tauopathy (PART), and chronic traumatic encephalopathy (CTE) all feature hyperphosphorylated tau (p-tau)-immunoreactive neurofibrillary degeneration, but differ in neuroanatomical distribution progression of degeneration amyloid beta (Aβ) deposition.
Noonan syndrome is a genetic condition with heterogeneous phenotype and multisystem involvement. The pathogenesis of this disorder has been attributed to the mutations in RAS/MAPK signaling pathway involved cell proliferation differentiation. most common clinical presentations are related cardiovascular abnormalities congestive heart failure as mechanism death. We present autopsy findings from patient who died result an unusual form right ventricular obstruction associated rare PTPN11...
Rathke cleft cysts (RCCs) are known sellar/suprasellar lesions that can grow and become symptomatic. For most asymptomatic lesions, stability is a typical outcome of surveillance; however, random relapse or cyst size fluctuation may also be observed. The conventional treatment for growing transsphenoidal removal. A literature review was conducted according to the Preferred Reporting Items Systematic Reviews Meta-Analysis (PRISMA) guidelines. significance, all journals were screened. Only...
Abstract Malignant tumors reprogram cellular metabolism, resulting in altered concentration of some metabolites. We measured glycine (GLY) and 2-hydroxyglutarate (2HG) 37 adult subjects with gliomas noninvasively using proton magnetic resonance spectroscopy examined their association immunochemical analyses tumor biopsies overall patient survival. MRS data were acquired optimized point-resolved (PRESS TE 97ms) at 3T the millimolar concentrations metabolites estimated reference to water. The...
Abstract Cancers reprogram their metabolism and the resulting alterations in metabolite concentrations may be closely related to clinical behavior of tumors. We evaluated glycine, glutamine 2-hydroxyglutarate (2HG) 16 adult subjects with glioblastomas (9 male 7 female; age 43-64 years, median 58) noninvasively using proton magnetic resonance spectroscopy examined association cell proliferation rate (MIB-1 labeling index) overall survival. MRS was acquired point-resolved (PRESS TE 97ms) at...
Abstract The proper balance of synthesis, folding, modification and degradation proteins, also known as protein homeostasis, is vital to cellular health function. unfolded response (UPR) activated when the mechanisms maintaining homeostasis in endoplasmic reticulum (ER) become overwhelmed. However, prolonged or strong UPR responses can result elevated inflammation damage. Previously, we discovered that bifunctional enzyme Fic modulate via post-translational BiP by AMPylation deAMPylation....