A5007429139- Nutrition and Health in Aging
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Muscle Physiology and Disorders
- Muscle metabolism and nutrition
- GDF15 and Related Biomarkers
- TGF-β signaling in diseases
- Adipose Tissue and Metabolism
- Cardiovascular and exercise physiology
- Plant responses to elevated CO2
- Respiratory Support and Mechanisms
- RNA modifications and cancer
- RNA Research and Splicing
- MicroRNA in disease regulation
- Pulmonary Hypertension Research and Treatments
- Intensive Care Unit Cognitive Disorders
- Kruppel-like factors research
- Cancer-related gene regulation
- Genetics and Physical Performance
- Genetic Syndromes and Imprinting
- Cell Adhesion Molecules Research
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Plant Water Relations and Carbon Dynamics
- Body Composition Measurement Techniques
- RNA and protein synthesis mechanisms
Imperial College London
2015-2024
Lung Institute
2010-2024
University of Amsterdam
2023
Amsterdam University Medical Centers
2023
Interface (United States)
2022
Leo Pharma (Denmark)
2019
United Nations Industrial Development Organization
2011-2017
Institute of Molecular Medicine
2017
National Health Service
2016
National Institute for Health Research
2012-2016
Quadriceps weakness is an important complication of advanced chronic obstructive pulmonary disease (COPD) but few data exist concerning muscle bulk in early disease. We hypothesised that quadriceps bulk, measured by ultrasound rectus femoris cross-sectional area (USRF CSA ), would be reduced mild, as well advanced, COPD compared with controls, and correlate physical activity. 161 patients stable 40 healthy subjects had a measurement USRF wore multisensor armband to record was Global...
Etude des reponses de germination 3 especes annuelles du desert Chihuahua en fonction la saison pluvieuse d'ete et d'hiver: Pectis angustifolia, Lepidium lasiocarpum Lappula redowskii
<h3>Rationale</h3> Muscle atrophy confers a poor prognosis in patients with chronic obstructive pulmonary disease (COPD), yet the molecular pathways responsible are poorly characterised. Muscle-specific microRNAs and serum response factor (SRF) important regulators of muscle phenotype that contribute to feedback system regulate gene expression. The role these factors skeletal dysfunction accompanies COPD is unknown. <h3>Methods</h3> 31 14 healthy age-matched controls underwent lung...
<h3>Background</h3> Skeletal muscle weakness in chronic obstructive pulmonary disease (COPD) carries a poor prognosis, therefore non-invasive marker of this process could be useful. Reduced expression muscle-specific microRNA (myomiRs) quadriceps patients with COPD is associated skeletal and changes fibre composition. Circulating exosomal miRNAs can measured blood, making them candidate biomarkers biopsy phenotype. To determine whether plasma myomiR levels were size or proportion, we myomiRs...
Abstract Background Loss of muscle mass is a co‐morbidity common to range chronic diseases including obstructive pulmonary disease (COPD). Several systemic features COPD increased inflammatory signalling, oxidative stress, and hypoxia are known increase the expression growth differentiation factor‐15 (GDF‐15), protein associated with wasting in other diseases. We therefore hypothesized that GDF‐15 may contribute COPD. Methods determined serum patients analysed association exercise...
<h3>Rationale</h3> The molecular mechanisms underlying the muscle atrophy of intensive care unit-acquired weakness (ICUAW) are poorly understood. We hypothesised that increased circulating and growth differentiation factor-15 (GDF-15) causes in ICUAW by changing expression key microRNAs. <h3>Objectives</h3> To investigate GDF-15 microRNA patients with to elucidate possible which they cause vivo vitro. <h3>Methods</h3> In an observational study, 20 seven elective surgical (controls) underwent...
1. A meta-analysis of 17 years literature on erythrocyte Na+/Li+ countertransport (NLCT) and Na+/K+ co-transport (COT) measurements in relation to essential hypertension is presented. The analysis aimed answer two questions: (i) Which clinical or laboratory variables influence NLCT COT flux values? (ii) How useful are as a diagnostic aid hypertension? 2. Regression was performed the mean values relevant values. Studies both normotensive hypertensive subjects were stratified for which showed...
Acute muscle wasting in the critically ill is common and causes significant morbidity. In a novel human model of acute following cardiac surgery, known or potential circulating modulators mass--insulin-like growth factor-1, myostatin, differentiation factor-15--were measured over week. It was hypothesized that patients who developed would show distinct patterns change these mediators.A prospective longitudinal observational study high-risk elective surgical identifying, by ultrasound, those...
Quadriceps muscle dysfunction is common in COPD. Determining, and, if possible, predicting quadriceps phenotype COPD important for patient stratification therapeutic trials.In biopsies from 114 patients and 30 controls, we measured fiber size proportion assessed the relationship with function (strength endurance), clinical (lung function, physical activity, fat-free mass) exercise performance. In a subset (n = 40) mid-thigh cross-sectional area by computed tomography.Normal ranges...
Abstract Background A loss of muscle mass occurs as a consequence range chronic and acute diseases well in older age. This wasting results from an imbalance protein synthesis degradation with reduction resistance to anabolic stimulation often reported features. Ribosomes are required for synthesis, so changes the control ribosome potential contributors wasting. MicroRNAs (miRNAs) known regulators phenotype have been shown modulate components synthetic pathway. One miRNA that is predicted...
Quadriceps muscle phenotype varies widely between patients with chronic obstructive pulmonary disease (COPD) and cannot be determined without biopsy. We hypothesised that measures of skeletal adiposity could provide noninvasive biomarkers quality in this population. In 101 10 age-matched healthy controls, mid-thigh cross-sectional area, percentage intramuscular fat attenuation were calculated using computed tomography images standard tissue ranges: -190– -30 HU; -29–150 HU. Mean± sd was...
Loss of skeletal muscle mass and function is a common consequence critical illness range chronic diseases, but the mechanisms by which this occurs are unclear.To identify microRNAs (miRNAs) that were increased in quadriceps patients with wasting to determine molecular pathways they contributed dysfunction.miRNA-542-3p/5p (miR-542-3p/5p) quantified obstructive pulmonary disease intensive care unit-acquired weakness (ICUAW). The effect miR-542-3p/5p was determined on mitochondrial transforming...
Smooth muscle (SM) develops only in organs and sites that sustain mechanical tensions. Therefore, we determined the role of stretch mouse human bronchial myogenesis. Sustained induced expression SM proteins undifferentiated mesenchymal cells accelerated differentiation undergoing Moreover, myogenesis was entirely controlled lung organ cultures by airway intraluminal pressure. Serum response factor (SRF) is a transcription critical for induction muscle-specific gene expression. Recently,...
1 The unusual kinetics of human ether-à-go-go-related gene (HERG) K+ channels are consistent with a role in the suppression arrhythmias initiated by premature beats. Action potential clamp protocols were used to investigate effect stimulation on HERG channels, transfected Chinese hamster ovary cells, at 37 °C. 2 channel currents peaked during terminal repolarization phase normally paced action waveforms. However, magnitude current and time point which conductance was maximal depended type...
The effects of light, temperature, and salinity on growth, net CO 2 exchange leaf anatomy Distichlis spicata were investigated in controlled environment chambers. When plants grown at low growth rates significantly reduced by high substrate or temperature. However, when not affected temperature salinity. capacity for light to overcome depressed cannot be explained completely photosynthesis, since caused decreases photosynthesis all environmental conditions. This salinity‐induced decrease was...