A5102927366- Adenosine and Purinergic Signaling
- Neuroinflammation and Neurodegeneration Mechanisms
- Medical Imaging Techniques and Applications
- Receptor Mechanisms and Signaling
- Immune cells in cancer
- Advanced Radiotherapy Techniques
- Trace Elements in Health
- Radiomics and Machine Learning in Medical Imaging
- Heavy Metal Exposure and Toxicity
- Drug Transport and Resistance Mechanisms
- Radiopharmaceutical Chemistry and Applications
- Pesticide Exposure and Toxicity
- Anesthesia and Neurotoxicity Research
- S100 Proteins and Annexins
University of California, Davis
2023-2024
Stanford University
2022-2023
Abstract Acute intoxication with cholinesterase inhibiting organophosphates (OP) can produce life-threatening cholinergic crisis and status epilepticus (SE). Survivors often develop long-term neurological consequences, including spontaneous recurrent seizures (SRS) impaired cognition. Numerous studies implicate OP-induced neuroinflammation as a pathogenic mechanism contributing to these chronic sequelae; however, little is known about the inflammatory phenotype of innate immune cells in...
Chronic innate immune activation is a key hallmark of many neurological diseases and known to result in the upregulation GPR84 myeloid cells (macrophages, microglia, monocytes). As such, can potentially serve as sensor proinflammatory responses. To assess utility an imaging biomarker, we synthesized 11C-MGX-10S 11C-MGX-11S via carbon-11 alkylation for use positron emission tomography (PET) tracers targeting this receptor. In vitro experiments demonstrated significantly higher binding both...