A5038926214- Medical Imaging Techniques and Applications
- Radiopharmaceutical Chemistry and Applications
- Fluorine in Organic Chemistry
- Radical Photochemical Reactions
- Cardiac, Anesthesia and Surgical Outcomes
- Airway Management and Intubation Techniques
- Chemical Reactions and Isotopes
- Medical History and Innovations
- Catalytic C–H Functionalization Methods
- Urological Disorders and Treatments
- Pediatric Urology and Nephrology Studies
- Synthesis and Biological Evaluation
- Photochromic and Fluorescence Chemistry
- Occupational Therapy Practice and Research
- Urinary Bladder and Prostate Research
- Computational Drug Discovery Methods
- Chemical Synthesis and Reactions
- Global Health and Surgery
- Dental Anxiety and Anesthesia Techniques
- Nuclear Physics and Applications
- Machine Learning in Materials Science
- Synthesis and Reactions of Organic Compounds
- Inorganic Fluorides and Related Compounds
- Radioactive element chemistry and processing
- Organ Donation and Transplantation
University of Michigan
2021-2024
Princeton University
2020
Augusta University Health
2020
Hope College
2019
Western University
1983
University of California, Los Angeles
1973-1974
University of British Columbia
1964-1968
Vancouver General Hospital
1964-1968
University of Lagos
1965-1968
Lagos University Teaching Hospital
1968
We report a redox-neutral method for nucleophilic fluorination of N-hydroxyphthalimide esters using an Ir photocatalyst under visible light irradiation. The provides access to broad range aliphatic fluorides, including primary, secondary, and tertiary benzylic fluorides as well unactivated that are typically inaccessible by due competing elimination. In addition, we show the decarboxylative conditions readily adapted radiofluorination with [18F]KF. propose reactions proceed two electron...
Positron emission tomography is a widely used imaging platform for studying physiological processes. Despite the proliferation of modern synthetic methodologies radiolabeling, optimization these reactions still primarily relies on inefficient one-factor-at-a-time approaches. High-throughput experimentation (HTE) has proven to be powerful approach optimizing in many areas chemical synthesis. However, date, HTE rarely been applied radiochemistry. This largely because short lifetime common...
Radiocyanation is an attractive strategy for incorporating carbon-11 into radiotracer targets, particularly given the broad scope of acyl moieties accessible from nitriles. Most existing methods aromatic radiocyanation require elevated temperatures (Cu-mediated reactions aryl halides or organometallics) involve expensive and toxic palladium complexes (Pd-mediated halides). The current report discloses a complementary approach that leverages capture radical intermediates by Cu–11CN complex to...
We present a photo- and Cu-mediated 11C cyanation of bench-stable (hetero)aryl thianthrenium salts via an aryl radical addition pathway. The substrates can be readily accessed C–H functionalization, the radiocyanation protocol proceeds under mild conditions (<50 °C, 5 min) automated using open-source, accessible augmentations to existing radiochemistry equipment.
Copper-mediated radiolabelling has revolutionised how (hetero)aromatic imaging agents are prepared for positron emission tomography (PET). Despite advancements, this radiochemistry fails to address critical stability, reactivity, and toxicity concerns encountered in many labelling systems, which paramount safely reproducibly generating patient radiomedicines. To overcome these limitations, a copper-mediated 11C-cyanation reaction is presented that leverages heptamethyltrisiloxanes as...
This report describes the development of a Zn(OTf)2 -mediated method for converting α-tertiary haloamides to corresponding fluorine-18 labelled fluoroamides with no-carrier-added [18 F]tetramethylammonium fluoride. 1,5,7-Triazabicyclo[4.4.0]dec-5-ene is an essential additive achieving high radiochemical conversion. Under optimised conditions, radiofluorination proceeds at sterically hindered tertiary sites in conversions, yields, and purities. has been successfully automated applied access...
Department of Anaesthesiology, The Vancouver General Hospital, Vancouver, British Columbia, Canada. Read at the 38th Congress International Anesthesia Research Society, March 15–19, 1964, Las Vegas, Nevada.
No AccessJournal of Urology1 Aug 1973Anesthesia for Voiding Cystourethrograms in Pediatric Patients Eric Webb and Willard E. Goodwin WebbEric More articles by this author GoodwinWillard View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)60181-2AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Anesthesia Patients." The Journal Urology, 110(2), pp. 259–260 © 1973 American Urological Association Education...
Our undergraduate research group has long focused on the preparation and investigation of electron-deficient analogs perimidinespirohexadienone (PSHD) family photochromic molecular switches for potential application as "photochromic photooxidants" gating sensitivity to photoinduced charge transfer. We previously reported photochemistry two closely related more reducible quinazolinespirohexadienones (QSHDs), wherein naphthalene PSHD is replaced with a quinoline. In present work, we report our...
Abstract This report describes the development of a Zn(OTf) 2 ‐mediated method for converting α‐tertiary haloamides to corresponding fluorine‐18 labelled fluoroamides with no‐carrier‐added [ 18 F]tetramethylammonium fluoride. 1,5,7‐Triazabicyclo[4.4.0]dec‐5‐ene is an essential additive achieving high radiochemical conversion. Under optimised conditions, radiofluorination proceeds at sterically hindered tertiary sites in conversions, yields, and purities. has been successfully automated...