A5009706825- Human-Animal Interaction Studies
- Epigenetics and DNA Methylation
- Diet and metabolism studies
- Gut microbiota and health
- Dietary Effects on Health
- Adipose Tissue and Metabolism
- Genetics, Aging, and Longevity in Model Organisms
- Rabies epidemiology and control
- Dementia and Cognitive Impairment Research
- Genetics and Neurodevelopmental Disorders
- Zoonotic diseases and public health
- Pediatric Pain Management Techniques
- Pancreatic function and diabetes
- Spaceflight effects on biology
- Veterinary Oncology Research
- Muscle Physiology and Disorders
- Veterinary Medicine and Surgery
- Muscle metabolism and nutrition
- Birth, Development, and Health
- Body Image and Dysmorphia Studies
- Health, Environment, Cognitive Aging
- Molecular Biology Techniques and Applications
- CRISPR and Genetic Engineering
- Aging, Elder Care, and Social Issues
- Metabolism, Diabetes, and Cancer
Arizona State University
2021-2025
Institute on Aging
2024
National Institute on Aging
2024
National Institutes of Health
2024
To gain insight into how researchers of aging perceive the process they study, we conducted a survey among experts in field. While highlighting some common features aging, exposed broad disagreement on foundational issues. What is aging? causes it? When does it begin? constitutes rejuvenation? Not only was there no consensus these and other core questions, but none questions received majority opinion-even regarding need for itself. Despite many believing understand their understanding...
Abstract Across mammals, the epigenome is highly predictive of chronological age. These “epigenetic clocks,” most which have been built using DNA methylation (DNAm) profiles, gained traction as biomarkers aging and organismal health. While ability DNAm to predict age has repeatedly demonstrated, other epigenetic features remains unclear. Here, we use two types information—DNAm, chromatin accessibility measured by ATAC‐seq—to develop predictors in peripheral blood mononuclear cells sampled...
Exposure to social environmental adversity is associated with health and survival across many species, including humans. However, little known about how these mortality effects vary the lifespan may be differentially impacted by various components of environment. Here, we leveraged a relatively new powerful model for human aging, companion dog, investigate which environment are dog associations lifespan. We drew on comprehensive survey data collected 21,410 dogs from Dog Aging Project...
Large scale data on the prevalence of diverse medical conditions among dog breeds in United States are sparse. This cross-sectional study sought to estimate lifetime US dogs and determine whether purebred have higher specific compared mixed-breed dogs.
Abstract A variety of diets have been studied for possible anti-aging effects. In particular, studies intermittent fasting and time-restricted feeding in laboratory rodents found evidence beneficial health outcomes. Companion dogs represent a unique opportunity to study diet large mammal that shares human environments. The Dog Aging Project has collecting data on thousands companion all different ages, sizes, breeds since 2019. We leveraged this diverse cross-sectional dataset investigate...
Dogs exhibit striking within-species variability in lifespan, with smaller breeds often living more than twice as long larger breeds. This longevity discrepancy also extends to health and aging-larger dogs show higher rates of age-related diseases. Despite this well-established phenomenon, we still know little about the biomarkers molecular mechanisms that might underlie breed differences aging survival. To address gap, generated an epigenetic clock using DNA methylation from over 3 million...
Abstract Within a species, larger individuals often have shorter lives and higher rates of age-related disease. Despite this well-known link, we still know little about underlying epigenetic differences, which could help us better understand inter-individual variation in aging the etiology, onset, progression age-associated Dogs exhibit negative correlation between size, health, longevity thus represent an excellent system to test mechanisms. Here, quantified genome-wide DNA methylation...
Abstract Our understanding of age-related physiology and metabolism has grown through the study systems biology, including transcriptomics, single-cell analysis, proteomics metabolomics. Studies in lab organisms controlled environments, while powerful complex, fall short capturing breadth genetic environmental variation nature. Thus, there is now a major effort geroscience to identify aging biomarkers develop interventions that might be applied across diversity humans other free-living...
Insulin resistance, stem cell dysfunction, and muscle fiber dystrophy are all age-related events in skeletal (SKM). However, changes insulin isoforms receptors myogenic progenitor satellite cells have not been studied. Since SKM is an extra-pancreatic tissue that does express mature insulin, we investigated the levels of (INSRs) a novel human upstream open reading frame (INSU) at mRNA, protein, anatomical Baltimore Longitudinal Study Aging (BLSA) biopsied samples 27-89-year-old (yrs)...
Companion dogs (Canis lupus familiaris) offer a unique model for studying the gut microbiome and its relation to aging due their cohabitation with humans, sharing similar environments, diets, healthcare practices. Here, we present Dog Aging Project (DAP) Precision cohort, largest population-wide study of canine date. This cohort encompasses over 900 diverse breeds, demographics living across United States. Coupling fecal shotgun metagenomic sequencing comprehensive phenotypic environmental...
Abstract Exposure to social environmental adversity is associated with health and survival in many species, including humans. However, little known about if how these mortality effects vary across the lifespan, largely due difficulty of studying long-lived organisms much their lifespan. Here, we leveraged a relatively new powerful model for human aging, companion dog, investigate which components environment are dog associations We drew on comprehensive survey data collected 21,410 dogs from...
Abstract Exposure to social environmental adversity strongly predicts health and survival in many species such as non-human primates, wild mammals, humans. However, little is known about how the mortality effects of these determinants vary across lifespan. Using companion dog, which serves a powerful comparative model for human aging due our shared biology environment, we examined components environment impact health, with age, dogs. We first drew on detailed survey data from owners 27,547...