A5064776150- Dietary Effects on Health
- Circadian rhythm and melatonin
- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Metabolism, Diabetes, and Cancer
- Genetics, Aging, and Longevity in Model Organisms
- Gut microbiota and health
- Neuroinflammation and Neurodegeneration Mechanisms
- Regulation of Appetite and Obesity
- Sphingolipid Metabolism and Signaling
- Alzheimer's disease research and treatments
- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Muscle metabolism and nutrition
- Intensive Care Unit Cognitive Disorders
- Birth, Development, and Health
- Peroxisome Proliferator-Activated Receptors
- Muscle Physiology and Disorders
- Family and Patient Care in Intensive Care Units
- Spaceflight effects on biology
- Sleep and related disorders
- Problem and Project Based Learning
- Parkinson's Disease Mechanisms and Treatments
- Innovative Teaching Methods
- Extracellular vesicles in disease
University of Utah
2021-2025
Salk Institute for Biological Studies
2013-2024
Huntsman Cancer Institute
2023
Hôpital de la Conception
2016
Centre de Recherche en Cancérologie de Marseille
2015
Inserm
2007-2015
Aix-Marseille Université
2007-2015
La Jolla Alcohol Research
2015
Centre for Innovation in Regulatory Science
2015
University of Palermo
2007
The gut microbiome and daily feeding/fasting cycle influence host metabolism contribute to obesity metabolic diseases. However, fundamental characteristics of this relationship between the are unknown. Our studies show that is highly dynamic, exhibiting cyclical fluctuations in composition. Diet-induced dampens rhythm diminishes many these fluctuations. Time-restricted feeding (TRF), which consolidated nocturnal phase, partially restores Furthermore, TRF, protects against diseases, affects...
Pancreatic cancer is a disease with an extremely poor prognosis. Tumor protein 53-induced nuclear 1 ( TP53INP1 ) proapoptotic stress-induced p53 target gene. In this article, we show by immunohistochemical analysis that expression dramatically reduced in pancreatic ductal adenocarcinoma (PDAC) and decrease occurs early during development. reexpression the cancer-derived cell line MiaPaCa2 strongly its capacity to form s.c., i.p., intrapancreatic tumors nude mice. This anti-tumoral is, at...
Abstract Antibiotic-induced microbiome depletion (AIMD) has been used frequently to study the role of gut in pathological conditions. However, unlike germ-free mice, effects AIMD on host metabolism remain incompletely understood. Here we show elucidate its homeostasis, luminal signaling, and metabolism. We demonstrate that AIMD, which decreases Firmicutes Bacteroidetes species, baseline serum glucose levels, reduces surge a tolerance test, improves insulin sensitivity without altering...
The AMP-activated protein kinase (AMPK) is a highly conserved master regulator of metabolism, whose activation has been proposed to be therapeutically beneficial for the treatment several metabolic diseases, including nonalcoholic fatty liver disease (NAFLD). NAFLD, characterized by excessive accumulation hepatic lipids, most common chronic and major risk factor development steatohepatitis, type 2 diabetes, other conditions. To assess therapeutic potential AMPK activation, we have generated...
Abstract Diabetes represents a spectrum of disease in which metabolic dysfunction damages multiple organ systems including liver, kidneys and peripheral nerves 1,2 . Although the onset progression these co-morbidities are linked with insulin resistance, hyperglycaemia dyslipidaemia 3–7 , aberrant non-essential amino acid (NEAA) metabolism also contributes to pathogenesis diabetes 8–10 Serine glycine closely related NEAAs whose levels consistently reduced patients syndrome 10–14 but...
Time-restricted feeding (TRF) is an emerging behavioral nutrition intervention that involves a daily cycle of and fasting. In both animals humans, TRF has pleiotropic health benefits arise from multiple organ systems, yet the molecular basis TRF-mediated not well understood. Here, we subjected mice to isocaloric ad libitum (ALF) or western diet examined gene expression changes in samples taken 22 organs brain regions collected every 2 h over 24-h period. We discovered profoundly impacts...
Significance Here, we show that cell autonomous circadian clock optimizes physiological regeneration of hair follicles by synchronizing mitotic progression in transient amplifying hair-matrix cells. The daily rhythm makes hairs grow faster the morning than evening. Also, because high sensitivity cells to radiation, significantly greater loss occurs evening following exposure same dose γ-radiation. These results provide a roadmap for developing new radiation therapy protocols, when...
Time-restricted feeding (TRF) is a nutritional intervention wherein food intake limited to consistent 8- 10-h daily window without changes in quality or quantity. TRF can prevent and treat diet-induced obesity (DIO) associated metabolic disease young male mice fed an obesogenic diet, the gold standard preclinical model for research. Because age sex are key biological variables affecting pathophysiology response therapies, we assessed their impact on benefits by subjecting 3-month-old...
Compositional oscillations of the gut microbiome are essential for normal peripheral circadian rhythms, both which disrupted in diet-induced obesity (DIO). Although time-restricted feeding (TRF) maintains synchrony and protects against DIO, its impact on dynamics cecal is modest. Thus, other regions gut, particularly ileum, nexus incretin bile acid signaling, may play an important role entraining rhythms. We demonstrate effect diet rhythms ileal composition transcriptome mice. The dynamic...
To gain insight into how researchers of aging perceive the process they study, we conducted a survey among experts in field. While highlighting some common features aging, exposed broad disagreement on foundational issues. What is aging? causes it? When does it begin? constitutes rejuvenation? Not only was there no consensus these and other core questions, but none questions received majority opinion-even regarding need for itself. Despite many believing understand their understanding...
Abstract Weight loss from an overweight state is associated with a disproportionate decrease in whole-body energy expenditure that may contribute to the heightened risk for weight regain. Evidence suggests this energetic mismatch originates lean tissue. Although phenomenon well documented, mechanisms have remained elusive. We hypothesized increased mitochondrial efficiency skeletal muscle reduced under loss. Wildtype (WT) male C57BL6/N mice were fed high-fat diet 10 weeks, followed by subset...
Abstract Objective Glucagon‐like peptide‐1 receptor agonists (e.g., semaglutide) potently induce weight loss, thereby reducing obesity‐related complications. However, regain occurs when treatment is discontinued. An increase in skeletal muscle oxidative phosphorylation (OXPHOS) efficiency upon diet‐mediated loss has been described, which may contribute to reduced systemic energy expenditure and regain. We set out determine the unknown effect of semaglutide on OXPHOS efficiency. Methods...
Maintaining natural feeding rhythms with time-restricted (TRF), without altering nutritional intake, prevents and reverses diet-induced obesity (DIO) its associated metabolic disorders in mice. TRF has a direct effect on animal adiposity, causes an alteration of adipokine signaling, diminishes white adipose tissue inflammation. Many genes involved lipid metabolism are normally circadian, but their expression is perturbed DIO; restores cyclical expression. One mechanism through which could...
Obesity is an established risk factor for breast cancer (BC), yet the specific mechanisms driving this association remain unclear. Dysregulated lipid metabolism has emerged as a key in cell biology. While obesity often accompanied by hyperlipidemia, isolated impact of elevated levels on BC growth not been experimentally tested. Using E0771 orthotopic model obesity-accelerated immune-competent mice, we investigated direct role systemic lipids tumor growth. Combining dietary and genetic mouse...