Tomoko Kasahara
A5066629879- Genetics, Aging, and Longevity in Model Organisms
- Frailty in Older Adults
- Neuroethics, Human Enhancement, Biomedical Innovations
- RNA Research and Splicing
- RNA and protein synthesis mechanisms
- Spaceflight effects on biology
- Health, Environment, Cognitive Aging
- Birth, Development, and Health
- RNA modifications and cancer
- Renal and related cancers
- Pluripotent Stem Cells Research
Tohoku University
2022-2024
To gain insight into how researchers of aging perceive the process they study, we conducted a survey among experts in field. While highlighting some common features aging, exposed broad disagreement on foundational issues. What is aging? causes it? When does it begin? constitutes rejuvenation? Not only was there no consensus these and other core questions, but none questions received majority opinion-even regarding need for itself. Despite many believing understand their understanding...
SUMMARY Health is strongly affected by aging and lifespan-modulating interventions, but the molecular mechanisms of mortality regulation remain unclear. Here, we conducted an RNA-seq analysis mice subjected to 20 compound treatments in Interventions Testing Program (ITP). By integrating it with data from over 4,000 rodent tissues representing responses genetic, pharmacological, dietary interventions established survival data, developed robust multi-tissue transcriptomic biomarkers mortality,...
SUMMARY Emerging evidence strongly supports a close relationship between age-related hearing loss and frailty, highlighting the importance of early detection intervention. Recently, we invented mitochondria-homing drug named mitochonic acid 5 (MA-5), that increases adenosine triphosphate (ATP) levels, rescue mitochondrial function, protect tissue damages. Currently, phase I clinical trial has been finished in Japan (jRCT2031210495) 2 already approved by PMDA. Here show MA-5 improved various...
Under stress conditions, transfer RNAs (tRNAs) are cleaved by stress-responsive RNases such as angiogenin, generating tRNA-derived called tiRNAs. As tiRNAs contribute to cytoprotection through inhibition of translation and prevention apoptosis, the regulation tiRNA production is critical for cellular response. Here, we show that RTCB ligase complex (RTCB-LC), an RNA involved in endoplasmic reticulum (ER) response precursor tRNA splicing, negatively regulates stress-induced production....
Abstract Aging clocks emerge have emerged as promising molecular estimators of biological age based on DNA methylation or transcriptomic profiles. Among other insights, they revealed “ground zero” aging during mouse embryogenesis characterized by the lowest age. To model dynamics human embryogenesis, we established a differentiation culture system that mimics embryonic kidney development from iPSCs. We then applied multiple to samples hiPSC organoid stages. This analyses around intermediate...