A5053530934- Monoclonal and Polyclonal Antibodies Research
- Celiac Disease Research and Management
- T-cell and B-cell Immunology
- Glycosylation and Glycoproteins Research
- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Immunology Research
- Evolution and Genetic Dynamics
- SARS-CoV-2 detection and testing
- Neuroethics, Human Enhancement, Biomedical Innovations
- HER2/EGFR in Cancer Research
- COVID-19 Impact on Reproduction
- Genetics, Aging, and Longevity in Model Organisms
- Reproductive System and Pregnancy
- Evolutionary Game Theory and Cooperation
- Toxin Mechanisms and Immunotoxins
- Food Allergy and Anaphylaxis Research
- Spaceflight effects on biology
Medical University of South Carolina
2024
Corvia Medical (United States)
2019
Insight (China)
2010
To gain insight into how researchers of aging perceive the process they study, we conducted a survey among experts in field. While highlighting some common features aging, exposed broad disagreement on foundational issues. What is aging? causes it? When does it begin? constitutes rejuvenation? Not only was there no consensus these and other core questions, but none questions received majority opinion-even regarding need for itself. Despite many believing understand their understanding...
Abstract The bispecific antibody IMV-M was designed to bind and cluster Death Receptor 5 (DR5) specifically upon engaging the tumor antigen MUC16. This dual-binding mechanism induces apoptosis in MUC16-positive cells through a novel enhancement process. exhibited potent, MUC16-selective anti-tumor activity vitro xenograft models, achieving efficacy at safe therapeutic doses without requiring secondary crosslinking. In contrast, earlier DR5-targeting tumor-selective antibodies either...
The bispecific antibody IMV-M was designed to selectively bind and cluster death receptor 5 (DR5) upon engaging the tumor antigen MUC16 through a novel mechanism—clustering multiple molecules on single molecule. demonstrated potent, MUC16-selective anti-tumor activity in vitro xenograft models without requiring secondary crosslinking, pilot non-human primate toxicity study detected no toxicity. Our findings suggest that clustering effectively induces DR5 clustering, resulting activity....
Autoimmunity is on the rise around globe. Diet has been proposed as a risk factor for autoimmunity and shown to modulate severity of several autoimmune disorders. Yet, interaction between diet in humans remains largely unstudied. Here, we systematically interrogated commonly consumed animals plants peptide epitopes previously implicated human disease. A total fourteen species investigated could be divided into three broad categories regarding their content epitopes, which represented using...
Diet is an environmental factor in autoimmune disorders, where the immune system erroneously destroys one's own tissues. Yet, interactions between diet and autoimmunity remain largely unexplored, particularly impact of immunogenetics, human leukocyte antigen (HLA) allele make-up, this interplay. Here, we interrogated animals plants for presence epitopes implicated diseases. We mapped epitope distribution across organisms determined their tissue expression pattern. Interestingly, diet-derived...
Abstract Diet is an environmental factor in autoimmune disorders, where the immune system erroneously destroys one’s own tissues. Yet, interactions between diet and autoimmunity remain largely unexplored, particularly impact of immunogenetics, human leukocyte antigen (HLA) allele make-up, this interplay. Here, we interrogated animals plants for presence epitopes implicated diseases. We mapped epitope distribution across organisms determined their tissue expression pattern. Interestingly,...
Abstract Autoimmunity is on the rise around globe. Diet has been proposed as a risk factor for autoimmunity and shown to modulate severity of several autoimmune disorders. Yet, interaction between diet in humans remains largely unstudied. Here, we systematically interrogated commonly consumed animals plants peptide epitopes previously implicated human disease. A total fourteen species investigated could be divided into three broad categories regarding their content epitopes, which...
Abstract 50 Million people in the United States are estimated to suffer from an autoimmune disease, and this number is predicted continue growing. Up 70% of cases could be due environmental factors. Therefore, understanding how diet, likely a major component factors described, impacts immune system merits exploration. We sought develop comparison between human epitopes implicated seventy diseases overlap them found various commonly consumed animals plants. The aim was construct comprehensive...
One of the most troubling developments 2021 has been number fertile-age women who have led to believe that mRNA vaccines against severe acute respiratory syndrome coronavirus-2 [SARS-CoV-2, coronavirus disease 2019 (COVID-19)] can cause infertility via cross-reactivity immune response. Specifically, developed antibodies syncytin-1, a protein found in human cell fusion, placentation and recently identified envelope gene endogenous defective retrovirus, HERV-W (see “Syncytin is captive...