A5089691721- Statistical Methods in Clinical Trials
- Epigenetics and DNA Methylation
- Genetic Associations and Epidemiology
- Bioinformatics and Genomic Networks
- Pelvic floor disorders treatments
- Biomedical Ethics and Regulation
- Anorectal Disease Treatments and Outcomes
- Genetic factors in colorectal cancer
- Genetics, Aging, and Longevity in Model Organisms
- Cancer Genomics and Diagnostics
- Global Health Workforce Issues
- Meta-analysis and systematic reviews
- Advances in Oncology and Radiotherapy
- Advanced Breast Cancer Therapies
- Metabolomics and Mass Spectrometry Studies
- Single-cell and spatial transcriptomics
- Colorectal Cancer Surgical Treatments
- Ethics in Clinical Research
- Genomics and Rare Diseases
- Metabolism, Diabetes, and Cancer
- SARS-CoV-2 detection and testing
- Global Health and Surgery
- Health Systems, Economic Evaluations, Quality of Life
- Gut microbiota and health
- Nutrition, Genetics, and Disease
Translational Genomics Research Institute
2019-2024
VA Loma Linda Healthcare System
2024
City Of Hope National Medical Center
2019-2021
City of Hope
2020-2021
Scripps Clinic Medical Group
2014-2018
J. Craig Venter Institute
2017
Scripps Research Institute
2013-2017
University of California, Berkeley
2012
Kaiser Permanente Oakland Medical Center
2009
University of Minnesota
2005-2006
This study was done to review the clinical presentation, surgical management, pathologic features, and prognostic factors for primary small-bowel cancers.Retrospective case series.Tertiary care, university hospital.One hundred twenty-nine patients were surgically treated between January 1, 1977, December 31, 2000. There 73 men 56 women, with a median age of 55 years (age range, 19-82 years). Median follow-up 36 months.Presenting symptoms signs, operations performed, features analyzed...
To gain insight into how researchers of aging perceive the process they study, we conducted a survey among experts in field. While highlighting some common features aging, exposed broad disagreement on foundational issues. What is aging? causes it? When does it begin? constitutes rejuvenation? Not only was there no consensus these and other core questions, but none questions received majority opinion-even regarding need for itself. Despite many believing understand their understanding...
Abstract Studies on humans that exploit contemporary data-intensive, high-throughput ‘omic’ assay technologies, such as genomics, transcriptomics, proteomics and metabolomics, have unequivocally revealed differ greatly at the molecular level. These differences, which are compounded by each individual’s distinct behavioral environmental exposures, impact individual responses to health interventions diet drugs. Questions about best way tailor individuals based their nuanced genomic,...
Recurrent rectal prolapse is an unresolved problem and the optimal treatment debated. This study was designed to review patterns of care outcomes in a large cohort patients after surgery for recurrent prolapse.From 685 who underwent operative repair full-thickness external prolapse, we identified 78 (70 females; mean age, 66.9 years) recurrence. We reviewed subsequent management these patients.Mean interval their first recurrence 33 (range, 1-168) months. There were significantly more...
There is growing interest in the development of interventions (e.g., drugs, diets, dietary supplements, behavioral therapies, etc.) that can enhance health during aging process, prevent or delay multiple age-related diseases, and ultimately extend lifespan. However, proving such 'geroprotectors' do what they are hypothesized to relevant clinical trials not trivial. We briefly discuss some more salient issues surrounding design interpretation geroprotectors, including, importantly, how one...
Anal sphincter injury secondary to obstetric trauma during vaginal delivery occurs in nearly one of every five women. Episiotomy, forceps delivery, and prolonged second stage labor have all been shown increase the risk disruption. One third these women will go on alterations anal continence ranging from occasional incontinence gas severely debilitating solid stool. Symptoms often arise many years after suggesting that factors such as nerve damage progressive degeneration muscle fibers...
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Abstract Large-scale genome-wide association studies (GWAS) strongly suggest that most traits and diseases have a polygenic component. This observation has motivated the development of disease-specific “polygenic scores (PGS)” are weighted sums effects disease-associated variants identified from GWAS correlate with an individual’s likelihood expressing specific phenotype. Although been pursued on disease traits, leading to creation refined “Polygenic Risk Scores” (PRS) quantify risk...
<title>Abstract</title> Information which may support an individual’s participation in a cancer phase I trial, such as their response to prior therapies, other medical conditions they have, features tumor genomic profile, etc., should be considered avoid negative consequences of participating the trial. However, knowing pieces information are relevant is crucial. We built predictive models responses trials using routinely collected demographic and clinical chemistry data. obtained data on...
Highlights Synergism of combined palbociclib/letrozole chemotherapy was examined by global metabolomics Combination therapy led to more pronounced effects on the MCF-7 metabolome than single agents Dietary phyto- and mycoestrogens significantly affected metabolic anti-oncogenic response drugs Implications these bio-active chemicals therapeutic success in breast cancer patients appear plausible In Brief Warth et al. used innovative pathway prediction technology describe therapy. Moreover,...
ABSTRACT The SARS-CoV-2 pandemic revealed the fragility of global supply chains, resulting in shortages essential clinical supplies for detection and treatment COVID-19, including nasopharyngeal swabs (NP) commonly used to collect samples respiratory disease diagnostics. Groups around world led a response find alternatives these shortages. Here, we describe development single-component swab (GrooveSwab) composed medical grade polypropylene that can be mass manufactured using conventional...