KeHuan Kuo Edmonds
A5041735814- RNA and protein synthesis mechanisms
- Genetics, Aging, and Longevity in Model Organisms
- RNA Research and Splicing
- RNA modifications and cancer
- Spaceflight effects on biology
- Neuroethics, Human Enhancement, Biomedical Innovations
Broad Institute
2024
Howard Hughes Medical Institute
2024
McGovern Institute for Brain Research
2024
Massachusetts Institute of Technology
2024
California Institute of Technology
2022
To gain insight into how researchers of aging perceive the process they study, we conducted a survey among experts in field. While highlighting some common features aging, exposed broad disagreement on foundational issues. What is aging? causes it? When does it begin? constitutes rejuvenation? Not only was there no consensus these and other core questions, but none questions received majority opinion-even regarding need for itself. Despite many believing understand their understanding...
Non-core spliceosome components are essential, conserved regulators of alternative splicing. They provide concentration-dependent control diverse pre-mRNAs. Many splicing factors direct unproductive their own pre-mRNAs through negative autoregulation. However, the impact such feedback loops on dynamics at single-cell level remains unclear. Here, we developed a system to quantitatively analyze autoregulatory by factor SRSF1 in response perturbations single HEK293 cells. We show that provides...