A5069689736- SARS-CoV-2 and COVID-19 Research
- Animal Virus Infections Studies
- Zoonotic diseases and public health
- Viral gastroenteritis research and epidemiology
- COVID-19 diagnosis using AI
- Plant Virus Research Studies
- Virology and Viral Diseases
- COVID-19 epidemiological studies
- Viral Infections and Vectors
- Bacteriophages and microbial interactions
- Viral Infections and Outbreaks Research
- Artificial Intelligence in Healthcare
- CRISPR and Genetic Engineering
- Rabies epidemiology and control
- COVID-19 Clinical Research Studies
- Spaceflight effects on biology
- Bacillus and Francisella bacterial research
- Genetics, Aging, and Longevity in Model Organisms
- Respiratory viral infections research
- Healthcare Systems and Practices
- Plant and Fungal Interactions Research
- Neuroethics, Human Enhancement, Biomedical Innovations
- Poxvirus research and outbreaks
- vaccines and immunoinformatics approaches
- Virus-based gene therapy research
Io Therapeutics (United States)
2024
Severe acute respiratory syndrome-coronavirus (SARS-CoV)-2's origin is still controversial. Genomic analyses show SARS-CoV-2 likely to be chimeric, most of its sequence closest bat CoV RaTG13, whereas receptor binding domain (RBD) almost identical that a pangolin CoV. Chimeric viruses can arise via natural recombination or human intervention. The furin cleavage site in the spike protein confers virus ability cross species and tissue barriers, but was previously unseen other SARS-like CoVs....
To gain insight into how researchers of aging perceive the process they study, we conducted a survey among experts in field. While highlighting some common features aging, exposed broad disagreement on foundational issues. What is aging? causes it? When does it begin? constitutes rejuvenation? Not only was there no consensus these and other core questions, but none questions received majority opinion-even regarding need for itself. Despite many believing understand their understanding...
RaTG13, MP789, and RmYN02 are the strains closest to SARS-CoV-2, their existence came light only after start of pandemic. Their genomes have been used support a natural origin SARS-CoV-2 but close examination all them exhibit several issues. We specifically address presence in closely related RacCSxxx claimed PAA/PVA amino acid insertion at S1/S2 junction spike protein same position where PRRA has created polybasic furin cleavage site. show that RmYN02/RacCSxxx instead carry 6-nucleotide...
Pekar et al. (2022) propose that SARS-CoV-2 was a zoonotic spillover first infected humans in the Huanan Seafood Market Wuhan, China. They there were two separate spillovers of closely related lineages A and lineage B short period time. The are differentiated by SNVs; hence, single-SNV A-B intermediate must have occurred an unsampled animal host if two-spillover hypothesis is correct. Consequently, confirmation existence genome from would falsify their spillovers. identified excluded 20...
Abstract Understanding how SARS-CoV-2 entered the human population, thereby causing COVID-19 pandemic, is one of most urgent questions in science today. Two hypotheses are widely acknowledged as being likely to explain pandemic’s origin late 2019: (i) “natural origin” hypothesis that or more cross-species transmissions from animals into humans occurred, at Huanan Seafood Market Wuhan, China; (ii) “laboratory hypothesis, scientific research activities led unintentional leak a laboratory...
Abstract Tyshkovskiy and Panchin have recently published a commentary on our paper in which they outline several “points of disagreement with the Segreto/Deigin hypothesis.” As is titled “The genetic structure SARS‐CoV‐2 does not rule out laboratory origin,” points should provide evidence that rules origin. However, no such instead attempt to criticize arguments highlight aspects could be consistent lab leak hypothesis. Strikingly, Panchin's main point criticism based false premise we...
In this study we document the unexpected discovery of multiple coronaviruses and a BSL-3 pathogen in agricultural cotton rice sequencing datasets. particular, have identified novel HKU5-related Merbecovirus dataset sequenced by Huazhong Agricultural University 2017. We also found an infectious clone sequence containing HKU4-related related to MERS coronavirus early 2020. Another Merbecovirus, as well Japanese encephalitis virus, were 2018. An HKU3-related Betacoronavirus was Mus musculus...
HKU4-related coronaviruses are a group of betacoronaviruses belonging to the same merbecovirus subgenus as Middle Eastern Respiratory Syndrome coronavirus (MERS-CoV), which causes severe respiratory illness in humans with mortality rate over 30%. The high genetic similarity between and MERS-CoV makes them an attractive subject research for modeling potential zoonotic spillover scenarios. In this study, we identify novel contaminating agricultural rice RNA sequencing datasets from Wuhan,...
The only animals other than bats reported to have been infected with SARS-CoV-2-related coronaviruses (SARS2r-CoVs) prior the COVID-19 pandemic are pangolins. In early 2020 multiple papers identification of two clades SARS2r-CoVs, GD and GX, infecting However RNA-Seq datasets supporting pangolin genome assembly were widely contaminated, contained synthetic vectors or heavily enriched filtered little but coronavirus sequences left in datasets. Here we investigate fecal samples sequenced by Li...
Pangolins are the only animals other than bats proposed to have been infected with SARS-CoV-2 related coronaviruses (SARS2r-CoVs) prior COVID-19 pandemic. Here, we examine novel SARS2r-CoV previously identified in game animal metatranscriptomic datasets sequenced by Nanjing Agricultural University 2022, and find that sections of partial genome phylogenetically group Guangxi pangolin CoVs (GX PCoVs), while full RdRp sequence groups bat-SL-CoVZC45. While is found 6 datasets, it also 10...
Metagenomic datasets from pangolin tissue specimens have previously yielded SARS-related coronaviruses which show high homology in their receptor binding domain to SARS-CoV-2, suggesting a potential zoonotic source for this feature of the human virus, possibly via recombination (Liu et al. 2019, Lam 2020, Xiao Liu 2020). Here we re-examine these published datasets. We report that only few samples were found contain coronavirus reads, and even then low abundance, while other non-pangolin...
There is a near consensus view that SARS-CoV-2 has natural zoonotic origin; however, several characteristics of taken together are not easily explained by origin hypothesis. These include: low rate evolution in the early phase transmission; lack evidence recombination events; high pre-existing binding to human ACE2; novel furin cleavage site insert; flat glycan domain spike protein which conflicts with host evasion survival patterns exhibited other coronaviruses, and mouse peptide mimicry....
Abstract HKU4-related coronaviruses (CoVs) are merbecoviruses related to Middle Eastern Respiratory Syndrome coronavirus (MERS-CoV). In 2022 and 2023, two CoV strains were discovered in Manis javanica (Malayan pangolin) metagenomic datasets derived from organ samples: HKU4-P251T MjHKU4r-CoV-1. Together with the Tylonycteris robustula bat 162275, which was 2022, pangolin CoVs MjHKU4r-CoV-1 form a novel phylogenetic clade distinct all previously documented CoVs. this study, we identified...
Zhou et al. reported the discovery of RmYN02, a strain closely related to SARS-CoV-2, which is claimed contain natural PAA amino acid insertion at S1/S2 junction spike protein same position PRRA that has created polybasic furin cleavage site in SARS-CoV-2. The authors support with their findings theory present SARS-CoV-2 natural. Because no nucleotide alignment strains region coding for supposed provided by al., we have applied several algorithms search most parsimonious alignments. We...
Questions about the origins of COVID-19 are more than academic interest. For moment, best explanation for seems to be that virus escaped from Wuhan Institute Virology, where scientists were engaged in creating novel SARS-like chimeras and potentially supercharging their transmissibility pathogenicity.
Pour le moment, la meilleure explication aux origines du COVID-19 semble être que virus s’est échappé de l’Institut Virologie Wuhan, où des scientifiques étaient engagés à créer nouvelles chimères type SARS et surcharger potentiellement leur transmissibilité pathogénicité.
Abstract Pangolins are the only animals other than bats proposed to have been infected with SARS-CoV-2 related coronaviruses (SARS2r-CoVs) prior COVID-19 pandemic. Here we examine novel SARS2r-CoV previously identified in game animal metatranscriptomic datasets sequenced by He et al. (2022) and find that sections of partial genome phylogenetically group Guangxi (GX) pangolin CoVs (GX PCoVs) while full RdRp sequence groups bat-SL-CoVZC45. While is found 6 datasets, same CoV also 10 additional...
Abstract Pangolins are the only animals other than bats proposed to have been infected with SARS-CoV-2related coronaviruses (SARS2r-CoVs) prior COVID-19 pandemic. Here we examine thenovel SARS2r-CoV previously identified in game animal metatranscriptomic datasetssequenced by He et al. (2022) and find that sections of partial genome phylogenetically groupwith Guangxi (GX) pangolin CoVs (GX PCoVs), while full RdRp sequence groups bat-SL-CoVZC45. While novel is found 6 datasets, same CoV isalso...