A5005094851- Hydrology and Watershed Management Studies
- Soil and Water Nutrient Dynamics
- Metabolomics and Mass Spectrometry Studies
- Flood Risk Assessment and Management
- Soil erosion and sediment transport
- Hydrological Forecasting Using AI
- Fire effects on ecosystems
- Urban Stormwater Management Solutions
- Advanced Proteomics Techniques and Applications
- Microbial Fuel Cells and Bioremediation
- Gut microbiota and health
- Microbial Community Ecology and Physiology
- Groundwater flow and contamination studies
- Nutritional Studies and Diet
- Analytical Chemistry and Chromatography
- Metabolism, Diabetes, and Cancer
- Mass Spectrometry Techniques and Applications
- Health, Environment, Cognitive Aging
- Advanced Breast Cancer Therapies
- Soil and Unsaturated Flow
- Wastewater Treatment and Nitrogen Removal
- Cryospheric studies and observations
- Cancer, Hypoxia, and Metabolism
- Genomics and Phylogenetic Studies
- Chromium effects and bioremediation
Scripps Institution of Oceanography
2022-2024
University College London
2024
Scripps Research Institute
2014-2023
National Institute of Water and Atmospheric Research
2018-2023
Scripps (United States)
2022-2023
US Forest Service
2017-2021
Hunter College
2017-2019
City University of New York
2015-2019
The King's College
2017-2019
IHE Delft Institute for Water Education
2012-2017
Thermal processes are widely used in small molecule chemical analysis and metabolomics for derivatization, vaporization, chromatography, ionization, especially gas chromatography mass spectrometry (GC/MS). In this study the effect of heating was examined on a set 64 standards and, separately, human plasma metabolite extracts. The samples, either derivatized or underivatized, were heated at three different temperatures (60, 100, 250 °C) exposure times (30 s, 60 300 s). All samples analyzed by...
Concurrent exposure to a wide variety of xenobiotics and their combined toxic effects can play pivotal role in health disease, yet are largely unexplored. Investigating the totality these exposures, i.e., "exposome", specific biological constitutes new paradigm for environmental but still lacks high-throughput, user-friendly technology. We demonstrate utility mass spectrometry-based global metabolomics with tailored database queries cognitive computing comprehensive assessment...
Aging | doi:10.18632/aging.100961. Julijana Ivanisevic, Kelly L Stauch, Michael Petrascheck, H Paul Benton, Adrian A Epstein, Mingliang Fang, Santhi Gorantla, Minerva Tran, Linh Hoang, E Kurczy, D Boska, Howard Gendelman, S Fox, Gary Siuzdak
Multiple heavy metal contamination is an increasingly common global problem. Heavy metals have the potential to disrupt microbially mediated biogeochemical cycling. However, systems-level studies on effects of combinations bacteria are lacking. For this study, we focused Oak Ridge Reservation (ORR; Ridge, TN, USA) subsurface which contaminated with several and high concentrations nitrate. Using a native Bacillus cereus isolate that represents dominant species at site, assessed combined...
Abstract Despite striking global change, management to ensure healthy landscapes and sustained natural resources has tended set objectives on the basis of historical range variability in stationary ecosystems. Many social–ecological systems are moving into novel conditions that can result ecological transformation. We present four foundations enable a transition future-oriented conservation increases capacity manage change. The identify plausible trajectories, apply upstream deliberate...
Abstract Saturation‐excess runoff is the major mechanism in humid well‐vegetated areas where infiltration rates often exceed rainfall intensity. Although Soil and Water Assessment Tool (SWAT) one of most widely used models, it predicts based mainly on soil land use characteristics, implicitly an infiltration‐excess type model. Previous attempts to incorporate saturation‐excess SWAT fell short due inability distribute water from hydrological response unit another. This paper introduces a...
Abstract In many parts of the world, watershed management practices have been extremely effective. However, implementation soil and water conservation technologies in humid African highlands, while beneficial short term, were remarkably unsuccessful long term. Insights from community knowledge perspectives revealed that alternative methods are needed. Although designed to conserve semi‐arid areas, safely draining excess is needed areas. The objective this paper review current approaches used...
Desulfovibrio alaskensis G20 biofilms were cultivated on 316 steel, 1018 or borosilicate glass under steady-state conditions in electron-acceptor limiting (EAL) and electron-donor (EDL) with lactate sulfate a defined medium. Increased corrosion was observed steel EDL compared to carbon the condition had at least twofold higher rates EAL condition. Protecting metal coupon from biofilm colonization significantly reduced corrosion, suggesting that mechanism enhanced through attachment between...
Competition between nitrate-reducing bacteria (NRB) and sulfate-reducing (SRB) for resources in anoxic environments is generally thought to be governed largely by thermodynamics. It now recognized that intermediates of nitrogen sulfur cycling (e.g., hydrogen sulfide, nitrite, etc.) can also directly impact NRB SRB activities freshwater, wastewater, sediment therefore may play important roles competitive interactions. Here, through comparative transcriptomic metabolomic analyses, we have...
Cancer cells that enter the metastatic cascade require traits allow them to survive within circulation and colonize distant organ sites. As disseminating cancer adapt their changing microenvironments, they also modify metabolism metabolite production.A mouse xenograft model of spontaneous tumor metastasis was used determine metabolic rewiring occurs between primary cancers metastases. An "autonomous" mass spectrometry-based untargeted metabolomic workflow with integrative pathway analysis...
Abstract. Uncertainty in hydrological modeling is of significant concern due to its effects on prediction and subsequent application watershed management. Similar other distributed models, model uncertainty an issue applying the Soil Water Assessment Tool (SWAT). Previous research has shown how SWAT predictions are affected by parameter estimation input data resolution. Nevertheless, little information available output varying complexity. In this study, SWAT-Hillslope (SWAT-HS), a modified...
The European Union Water Framework Directive requires an integrated pollution prevention plan at the river basin level. Hydrological modeling tools are therefore promising to support quantification of originating from different sources. A limited number studies have reported on use these models predict fluxes in tile-drained basins. This study focused evaluating and concepts quantify flow nitrate Odense River using DAISY-MIKE SHE (DMS) Soil Assessment Tool (SWAT). results show that SWAT...
The microbial-derived metabolite, 3-indolepropionic acid (3-IPA), has been intensely studied since its origins were discovered in 2009; however, 3-IPA's role immunosuppression had limited attention. Untargeted metabolomic analyses of T-cell exhaustion and immunosuppression, represented by dysfunctional under-responsive CD8+ T cells, reveal a potential 3-IPA these responses. was examined via infection two genetically related mouse strains, DBA/1J DBA/2J, with lymphocytic choriomeningitis...
The Soil Water Assessment Tool (SWAT) is employed throughout the world to simulate watershed processes. A limitation of this model that locations saturation excess overland flow in hilly and mountainous regions with an impermeable layer at shallow depth cannot be simulated realistically. objective research overcome minor changes original SWAT code. new approach called SWAT-with-impervious-layers (SWAT-wil). Adaptations consisted redefining hillslope length, restricting downward percolation...
The aims of this study were to determine whether combination chemotherapeutics exhibit a synergistic effect on breast cancer cell metabolism. Palbociclib, is selective inhibitor cyclin-dependent kinases 4 and 6, when patients are treated in with fulvestrant, an estrogen receptor antagonist, they have improved progression-free survival. mechanisms for survival advantage not known. Therefore, we analyzed metabolic transcriptomic changes MCF-7 cells following single chemotherapy pathways...
Nitrogen loading from diffuse agricultural sources is a major water-quality problem worldwide. Constructed wetlands have been increasingly used to treat runoff and drainage lands. However, the nature of nitrogen farmlands often makes it challenging trace flow pathways measure direct input wetlands, assess their nutrient-reduction performance. The Owl Farm wetland, Cambridge, New Zealand, receives inputs mainly subsurface drain groundwater seepage. As was not possible directly wetland...