A5085888006- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Primate Behavior and Ecology
- Gut microbiota and health
- Transcranial Magnetic Stimulation Studies
- Functional Brain Connectivity Studies
- Neuroendocrine regulation and behavior
- Cardiac Health and Mental Health
- Animal Behavior and Reproduction
- HIV Research and Treatment
- Long-Term Effects of COVID-19
- HIV/AIDS Research and Interventions
- Health disparities and outcomes
- COVID-19 and Mental Health
- Intensive Care Unit Cognitive Disorders
- Dementia and Cognitive Impairment Research
- Evolutionary Psychology and Human Behavior
- HIV-related health complications and treatments
- Diet and metabolism studies
- Neural dynamics and brain function
- Obsessive-Compulsive Spectrum Disorders
- Cancer survivorship and care
- Maternal Mental Health During Pregnancy and Postpartum
- Pain Management and Treatment
- Psychosomatic Disorders and Their Treatments
University of California, San Diego
1996-2025
Human Longevity (United States)
2023-2025
Johns Hopkins University
2022-2024
San Diego State University
2023
Colorado State University
2023
Institute on Aging
2022
Emory University
2012-2021
American Orchid Society
2021
University of Miami
2019
Palo Alto University
2019
Status alters immune function in macaques Rhesus experience variable levels of stress on the basis their position social hierarchy. To examine how affects function, Snyder-Mackler et al. manipulated status individual (see Perspective by Sapolsky). Social influenced system at multiple levels, from cell numbers to gene expression, and altered signaling pathways a model response infection. Macaques possess plastic adaptive wherein subordination promotes antibacterial responses, whereas high...
Low social status is an important predictor of disease susceptibility and mortality risk in humans other mammals. These effects are thought to stem part from dysregulation the glucocorticoid (GC)-mediated stress response. However, molecular mechanisms that connect low GC downstream health outcomes remain elusive. Here, we used vitro challenge investigate consequences experimentally manipulated (i.e., dominance rank) for immune cell gene regulation female rhesus macaques, using paired control...
Abstract Field studies of wild vertebrates are frequently associated with extensive collections banked fecal samples—unique resources for understanding ecological, behavioral and phylogenetic effects on the gut microbiome. However, we do not understand whether sample storage methods confound ability to investigate interindividual variation in microbiome profiles. Here, extend previous work samples by comparing immediate freezing, gold standard preservation, three commonly used vertebrate...
Significance Humans and our close evolutionary relatives respond differently to a large number of infections. Such differences are thought result, at least in part, from interspecies immune function. Here, we report on the whole-genome expression blood leukocytes four primate species responding bacterial viral stimulation. We show that apes mount markedly stronger early transcriptional response both stimulation when compared African Asian monkeys. In addition, findings suggest activate...
Long COVID is a chronic condition characterized by symptoms such as fatigue, dyspnea, and cognitive impairment that persist or relapse months after an acute infection with the SARS-CoV-2 virus. Many distinct have been attributed to COVID; however, little known about potential clustering of these risk factors may predispose patients certain clusters. In this study, electronic survey was sent in UC San Diego Health (UCSDH) system who tested positive for COVID-19, querying if were experiencing...
Objective: The authors sought to determine the impact of selected social determinants health (SDoH) on psychological and well-being (defined as depression, cognition, self-rated health) among Black Hispanic/Latinx adults relative White 51–89 years age. Methods: Disparities in depressive symptomatology, were measured 2,306 non–Hispanic/Latinx Black, 1,593 Hispanic/Latinx, 7,244 who participated Health Retirement Study (N=11,143). Blinder-Oaxaca decomposition was used examine whether...
BACKGROUND Depression is common during and after breast cancer treatment. However, the role of specific therapeutic modalities related biologic mechanisms remains unclear. Radiation an essential component breast‐conserving therapy may contribute to depression in patients with through activation inflammatory pathways. METHODS Depressive symptoms mediators, including nuclear factor kappa B (NF‐κB), were assessed at baseline (before radiation), radiation, 6 weeks radiation 64 women who had...
Non-allelic homologous recombination (NAHR), non-homologous end joining (NHEJ), and microhomology-mediated replication-dependent (MMRDR) have all been put forward as mechanisms to explain DNA rearrangements associated with genomic disorders. However, many nonrecurrent in humans remain unexplained. To further investigate the mutation of these copy number variations (CNVs), we performed breakpoint mapping analysis for 62 clinical cases intragenic deletions human DMD gene (50 cases) other known...
This randomized clinical trial evaluates the effect of accelerated intermittent theta-burst stimulation, compared with sham on depression severity in individuals treatment-resistant bipolar depression.
Abstract Nicotinic acetylcholine receptors (nAChRs) are important regulators of brain and immune function that play critical roles in the neuropathology progression Alzheimer’s disease related dementias (ADRD). However, quantifying nAChRs remains elusive, little is known about peripheral measures nAChR older adults or their relationship to cognition. Here, we examined associations between expression immunoregulatory blood monocytes cognitive performance among 167 (age 72.3 ± 7.6 years; 71%...
Significance Social adversity is strongly linked to health and fitness outcomes in humans other social mammals. This observation arises part through “biological embedding”: persistent, environment-induced biological changes that may affect immune function. Here we show low status female rhesus macaques leads a highly proinflammatory response both bacterial viral challenge. In addition, past also affects gene expression, reduced sensitivity current conditions. Thus, the first line of defense...
ABSTRACT Introduction Clinical heterogeneity of limb‐girdle muscular dystrophies ( LGMDs , 24 known subtypes), which includes overlapping phenotypes and varying ages onset morbidity, adds complexity to clinical molecular diagnoses. Methods To diagnose LGMD subtype, protein analysis, using immunohistochemistry IHC ) immunoblotting, was followed by gene sequencing through a panel approach (simultaneous genes) in 9 patients from unrelated families the Indian Agarwal community. Haplotype studies...
Major depressive disorder (MDD) is a leading cause of disability worldwide. One the most efficacious treatments for treatment-resistant MDD electroconvulsive therapy (ECT). Recently, magnetic seizure (MST) was developed as an alternative to ECT due its more favorable side effect profile. While these approaches have been very successful clinically, neural mechanisms underlying their therapeutic effects are unknown. For example, clinical "slowing" electroencephalogram beginning in postictal...
This study examined the relationship between psychomotor abilities and baseball performance by analysing data from 379 athletes who participated in USA Baseball, Prospect Development Pipeline (PDP). Hit pitch metrics were generated during practice sessions using RapsodoTM System. Data compared through exploratory factor analysis hierarchical regression. Factor grouped batter's PDP evaluations into four latent variables accounting for 63% of variance. Pitcher three factors 51% Regression on...
A study was carried out to assess the effect of total body irradiation on pancreatic and parotid isoenzymes amylase in patients about undergo bone-marrow transplantation who had received high-dose cyclophosphamide. Twelve were studied, enzyme activity being measured before at various times after irradiation. Serum rose rapidly within 12 hours a maximum 36 hours, returning normal by six days; most increase derived from salivary damage, with much smaller component. These results confirm that...