A5034599481- Helminth infection and control
- Parasite Biology and Host Interactions
- Parasites and Host Interactions
- interferon and immune responses
- Immune Response and Inflammation
- Metabolomics and Mass Spectrometry Studies
- HIV Research and Treatment
- Zoonotic diseases and public health
- Research on scale insects
- Immune cells in cancer
- T-cell and B-cell Immunology
- Celiac Disease Research and Management
- Galectins and Cancer Biology
- Livestock and Poultry Management
- Microscopic Colitis
- Plant Physiology and Cultivation Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Evolution and Genetic Dynamics
- Influenza Virus Research Studies
- Animal Disease Management and Epidemiology
- Viral Infections and Vectors
- Vector-borne infectious diseases
- Parasitic infections in humans and animals
- Insect-Plant Interactions and Control
- Yersinia bacterium, plague, ectoparasites research
Centre Hospitalier Universitaire Sainte-Justine
2016-2024
Université de Montréal
2020-2023
Hospital for Sick Children
2023
Cairo University
2015-2022
University of Copenhagen
2015-2016
National Research Centre
1972
Significance Humans and our close evolutionary relatives respond differently to a large number of infections. Such differences are thought result, at least in part, from interspecies immune function. Here, we report on the whole-genome expression blood leukocytes four primate species responding bacterial viral stimulation. We show that apes mount markedly stronger early transcriptional response both stimulation when compared African Asian monkeys. In addition, findings suggest activate...
The whipworms Trichuris trichiura and suis are two parasitic nematodes of humans pigs, respectively. Although in human non-human primates historically have been referred to as T. trichiura, recent reports suggest that several spp. found primates.We sequenced annotated complete mitochondrial genomes recovered from a Uganda, an olive baboon the US, hamadryas Denmark, pigs Denmark Uganda. Comparative analyses using other published porcine host China françois' leaf-monkey (China) were performed,...
Since the nematodes Trichuris trichiura and T. suis are morphologically indistinguishable, genetic analysis is required to assess epidemiological cross-over between people pigs. This study aimed clarify transmission biology of trichuriasis in Ecuador. Adult worms were collected during a parasitological survey 132 46 pigs Esmeraldas Province, Morphometric 49 pig 64 human revealed significant variation. In discriminant morphometric characteristics correctly classified male according host...
Trichuris suis and T. trichiura are two different whipworm species that infect pigs humans, respectively. is found in worldwide while responsible for nearly 460 million infections people, mainly areas of poor sanitation tropical subtropical areas. The evolutionary relationship the historical factors this distribution poorly understood. In study, we aimed to reconstruct demographic history humans pigs, origin these hosts parasite dispersal globally. Parts mitochondrial nad1 rrnL genes were...
Abstract Vertebrates differ over 100,000-fold in responses to pro-inflammatory agonists such as bacterial lipopolysaccharide (LPS), complicating use of animal models study human sepsis or inflammatory disorders. We compared transcriptomes resting and LPS-exposed blood from six LPS-sensitive species (rabbit, pig, sheep, cow, chimpanzee, human) four LPS-resilient (mice, rats, baboon, rhesus), well plasma proteomes lipidomes. Unexpectedly, at baseline, sensitive already had enhanced expression...
Abstract Excess of nitrogen, potassium and phosphorous in the nutritional source citrus seedlings ( Citrus sinensis L. var. baladi ) increased their resistance to infestation with red scale, Aonidiella aurantii (Maskell), while decrease caused plant be highly susceptible. On other hand, excess or all them susceptibility plants purple scale Lepidosaphes beckii (Newman). These findings coincide field observations which indicate that is more distributed orchards sand soils characterised by...
Vertebrates differ greatly in responses to pro-inflammatory agonists such as bacterial lipopolysaccharide (LPS), complicating use of animal models study human sepsis or inflammatory disorders. We compared transcriptomes resting and LPS-exposed blood from six LPS-sensitive species (rabbit, pig, sheep, cow, chimpanzee, human) four LPS-resilient (mice, rats, baboon, rhesus), well plasma proteomes lipidomes. Unexpectedly, at baseline, sensitive already had enhanced expression LPS-responsive...
Abstract Host defense mechanisms are categorized into different strategies, namely, avoidance, resistance and tolerance. Resistance encompasses that directly kill the pathogen while tolerance is mainly concerned with alleviating harsh consequences of infection regardless burden. well‐known strategy in immunology relatively new. Studies addressed using mouse models revealing a wide range interesting mechanisms. Herein, we aim to emphasize on interspecies comparative approaches explore...
Abstract Despite their close genetic relatedness, apes and African Asian monkeys (AAMs), strongly differ in susceptibility to severe bacterial viral infections that are important causes of human disease. Such differences between humans other primates thought be a result, at least part, inter-species immune response infection. However, due the lack comparative functional data across species, it remains unclear what ways systems differ. Here, we report whole genome transcriptomic responses ape...
Abstract Immune response is known to be under constant pressure evolutionary from different factors including pathogens. Although selection regimes are expected act on the magnitude of immune response, there limited studies that investigated patterns pressures quantitatively. I employed models (Ornstein-Uhlenbeck models) identify antiviral fibroblasts derived 18 mammalian species and one vertebrate stimulated by viral ligand, poly I:C, or Interferon alpha cytokine. found stabilizing dominant...