A5071444739- Genomics and Phylogenetic Studies
- Chromosomal and Genetic Variations
- Advanced biosensing and bioanalysis techniques
- CRISPR and Genetic Engineering
Wellcome/Cancer Research UK Gurdon Institute
2022-2025
University of Cambridge
2022-2025
Abstract Background East African cichlid fishes have diversified in an explosive fashion, but the (epi)genetic basis of phenotypic diversity these remains largely unknown. Although transposable elements (TEs) been associated with variation cichlids, little is known about their transcriptional activity and epigenetic silencing. We set out to bridge this gap understand interactions between TEs hosts. Results Here, we describe dynamic patterns TE expression gonads during early development....
Transposable elements (TEs) are mobile DNA sequences that make up a sizeable fraction of mammalian genomes yet often tightly repressed by transcriptional and epigenetic mechanisms. During early development, reprogramming selectively loosens TE repression, transcription actively contributes to embryogenesis. This raises the question: how can embryos embryonic stem cells (ESCs) tolerate expression without incurring widespread inflammation or damage? Here, we reveal multiple mechanisms prevent...
Abstract East African cichlid fishes have diversified in an explosive fashion, but the (epi)genetic basis of phenotypic diversity these remains largely unknown. Although transposable elements (TEs) been associated with variation cichlids, little is known about their transcriptional activity and epigenetic silencing. Here, we describe dynamic patterns TE expression gonads during early development. Orthology inference revealed expansion piwil1 genes Lake Malawi likely driven by PiggyBac TEs....