A5039559105- Extracellular vesicles in disease
- Aquaculture disease management and microbiota
- MicroRNA in disease regulation
- CRISPR and Genetic Engineering
- Animal Behavior and Reproduction
- Chromosomal and Genetic Variations
- Physiological and biochemical adaptations
- Neurobiology and Insect Physiology Research
- Developmental Biology and Gene Regulation
- Biochemical Analysis and Sensing Techniques
- Genomics and Phylogenetic Studies
- melanin and skin pigmentation
- Genetic diversity and population structure
- Bat Biology and Ecology Studies
- Olfactory and Sensory Function Studies
- Fish biology, ecology, and behavior
- RNA regulation and disease
University of Cambridge
2022-2024
ABSTRACT Vertebrate pigmentation patterns are amongst the best characterised model systems for studying genetic basis of adaptive evolution. The wealth available data on evolution allows analysis trends and quantitative testing evolutionary hypotheses. We employed Gephebase , a database variants associated with natural domesticated trait variation, to examine in how cis ‐regulatory coding mutations contribute vertebrate phenotypes, as well factors that favour one mutation type over other....
Abstract Chromosomal inversions contribute to adaptive speciation by linking co-adapted alleles. Querying 1,375 genomes of the species-rich Malawi cichlid fish radiation, we discovered five large segregating in benthic subradiation that each suppress recombination over more than half a chromosome. Two were transferred from deepwater pelagic Diplotaxodon via admixture, while others established early deep clade. Introgression haplotypes lineages inside and outside radiation coincided with...
Identifying genetic loci underlying trait variation provides insights into the mechanisms of diversification, but demonstrating causality and characterizing role requires testing candidate gene function, often in non-model species. Here we establish CRISPR/Cas9 editing Astatotilapia calliptera, a generalist cichlid remarkably diverse Lake Malawi radiation. By targeting oca2 required for melanin synthesis other vertebrate species, show efficient germline transmission. Gene edits include...
Abstract Vertebrate pigmentation patterns are amongst the best characterised model systems for studying genetic basis of adaptive evolution. The wealth available data on evolution allows meta-analysis trends and quantitative testing evolutionary hypotheses. We employed Gephebase, a database variants associated with natural domesticated trait variation, to examine in how cis -regulatory coding mutations contribute vertebrate phenotypes, as well factors that favour one mutation type over...
Abstract Vertebrate pigmentation patterns are highly diverse, yet we have a limited understanding of how evolutionary changes to genetic, cellular, and developmental mechanisms generate variation. To address this, examine the formation sexually‐selected male ornament exhibiting inter‐ intraspecific variation, egg‐spot pattern, consisting circular yellow‐orange markings on anal fins haplochromine cichlid fishes. We focus Astatotilapia calliptera , ancestor‐type species Malawi adaptive...
Abstract Identifying genetic loci underlying trait variation provides insights into the mechanisms of diversification, but demonstrating causality and characterising role requires testing candidate gene function, often in non-model species. Here we establish CRISPR/Cas9 editing Astatotilapia calliptera , a generalist cichlid remarkably diverse Lake Malawi radiation. By targeting oca2 required for melanin synthesis other vertebrate species, show efficient germline transmission. Gene edits...
ABSTRACT Vertebrate pigmentation patterns are highly diverse, yet we have a limited understanding of how evolutionary changes to genetic, cellular, and developmental mechanisms generate variation. To address this, examine the formation sexually-selected male ornament exhibiting inter- intra-specific variation, egg-spot pattern, consisting circular yellow-orange markings on anal fins haplochromine cichlid fishes. We focus Astatotilapia calliptera , ancestor-type species Malawi adaptive...