A5025592391- Genetic and phenotypic traits in livestock
- melanin and skin pigmentation
- Genetic Mapping and Diversity in Plants and Animals
- Genetic diversity and population structure
- Veterinary Equine Medical Research
- Public Administration and Political Analysis
- Cancer-related molecular mechanisms research
- Law and Political Science
- Animal Genetics and Reproduction
- Molecular Biology Techniques and Applications
- Criminal Law and Policy
- Sociology and Education Studies
- Mast cells and histamine
- RNA regulation and disease
- Animal Diversity and Health Studies
- Immunotherapy and Immune Responses
- Horticultural and Viticultural Research
- Milk Quality and Mastitis in Dairy Cows
- Agriculture and Rural Development Research
- Silkworms and Sericulture Research
- Animal Disease Management and Epidemiology
- Biochemical Analysis and Sensing Techniques
- T-cell and B-cell Immunology
- Microbial Metabolism and Applications
- Social Policies and Healthcare Reform
Praxis
2022
Agroscope
2012-2019
Interface Politikstudien (Switzerland)
2003-2019
Bern University of Applied Sciences
2010-2017
University of Bern
2003-2017
Federal Office for Agriculture
2012-2013
Medical University of Graz
2013
Swiss Federal University for Vocational Education and Training SFUVET
2004-2011
École Polytechnique Fédérale de Lausanne
2000-2005
University of Zurich
2003
Intense selective pressures applied over short evolutionary time have resulted in homogeneity within, but substantial variation among, horse breeds. Utilizing this population structure, 744 individuals from 33 breeds, and a 54,000 SNP genotyping array, breed-specific targets of selection were identified using an FST-based statistic calculated 500-kb windows across the genome. A 5.5-Mb region ECA18, which myostatin (MSTN) gene was centered, contained highest signature both Paint Quarter...
Horses were domesticated from the Eurasian steppes 5,000–6,000 years ago. Since then, use of horses for transportation, warfare, and agriculture, as well selection desired traits fitness, has resulted in diverse populations distributed across world, many which have become or are process becoming formally organized into closed, breeding (breeds). This report describes a genome-wide set autosomal SNPs 814 36 breeds to provide first detailed description equine breed diversity. FST calculations,...
Ancient genomics of horse domestication The the was a seminal event in human cultural evolution. Librado et al. obtained genome sequences from 14 horses Bronze and Iron Ages, about 2000 to 4000 years ago, soon after domestication. They identified variants determining coat color genes selected during process. could also see evidence admixture with archaic demography process, which included accumulation deleterious variants. appears have undergone different type process than animals that were...
The molecular analysis of genes influencing human height has been notoriously difficult. Genome-wide association studies (GWAS) for in humans based on tens thousands to hundreds samples so far revealed ∼200 loci explaining only 20% the heritability. In domestic animals isolated populations with a greatly reduced genetic heterogeneity facilitate more efficient complex traits. We performed genome-wide study 1,077 Franches-Montagnes (FM) horses using ∼40,000 SNPs. Our two QTL at withers...
Significance Yakutia is among the coldest regions in Northern Hemisphere, showing ∼40% of its territory above Arctic Circle. Native horses are particularly adapted to this environment, with body sizes and thick winter coats minimizing heat loss. We sequenced complete genomes two ancient nine present-day Yakutian elucidate their evolutionary origins. find that contemporary population descends from domestic livestock, likely brought by early horse-riders who settled region a few centuries ago....
During fetal development neural-crest-derived melanoblasts migrate across the entire body surface and differentiate into melanocytes, pigment-producing cells. Alterations in this precisely regulated process can lead to white spotting patterns. White patterns horses are a complex trait with large phenotypic variance ranging from minimal markings up completely horses. The “splashed white” pattern is primarily characterized by an extremely blaze, often accompanied extended at distal limbs blue...
To date, genome-scale analyses in the domestic horse have been limited by suboptimal single nucleotide polymorphism (SNP) density and uneven genomic coverage of current SNP genotyping arrays. The recent availability whole genome sequences has created opportunity to develop a next generation, high-density equine array. Using sequence from 153 individuals representing 24 distinct breeds collated genomics community, we cataloged over 23 million de novo discovered genetic variants. Leveraging...
White coat color has been a highly valued trait in horses for at least 2,000 years. Dominant white (W) is one of several known depigmentation phenotypes horses. It shows considerable phenotypic variation, ranging from ∼50% depigmented areas up to completely coat. In the horse, four roan, sabino, tobiano, and dominant were independently mapped chromosomal region on ECA 3 harboring KIT gene. plays an important role melanoblast survival during embryonic development. We determined sequence...
White coat colour in horses is inherited as a monogenic autosomal dominant trait showing variable expression of depigmentation. Mutations the KIT gene have previously been shown to cause white phenotypes pigs, mice and humans. We recently also demonstrated that four independent mutations equine are responsible for phenotype various horse breeds. now analysed additional families segregating report seven new Thoroughbred, Icelandic Horse, German Holstein, Quarter Horse South Draft families. In...
Summary Variants in the EDNRB , KIT MITF PAX 3 and TRPM 1 genes are known to cause white spotting phenotypes horses, which can range from common markings up completely horses. In this study, we investigated these candidate 169 horses with not explained by previously described variants. We identified a novel missense variant, :p.Pro32Arg, Appaloosa splashed phenotype addition their leopard complex patterns. also found three variants gene. The splice site variant c.1346+1G>A occurred Swiss...
Effective population size is an important parameter for the assessment of genetic diversity within a livestock and its development over time. If pedigree information not available, linkage disequilibrium (LD) analysis might offer alternative perspective estimation effective size. In this study, 128 individuals Swiss Eringer breed were genotyped using Illumina BovineSNP50 beadchip. We set bin at 50 kb LD analysis, assuming that proximal single nucleotide polymorphism (SNP)-pairs reflects...
The identification of quantitative trait loci (QTL) such as height and their underlying causative variants is still challenging often requires large sample sizes. In humans hundreds with small effects control the heritable portion variability. domestic animals, typically only a few comparatively explain major fraction heritability. We investigated at withers in Shetland ponies mapped QTL to ECA 6 by genome-wide association (GWAS) using cohort 48 animals Illumina equine SNP70 BeadChip....
Analysis of the Y chromosome is best-established way to reconstruct paternal family history in humans. Here, we applied fine-scaled Y-chromosomal haplotyping horses with biallelic markers and demonstrate potential our approach address ancestry sire lines. We de novo assembled a draft reference male-specific region from Illumina short reads then screened 5.8 million basepairs for variants 130 specimens intensively selected rural breeds nine Przewalski's horses. Among domestic confirmed...
The Y chromosome is a valuable genetic marker for studying the origin and influence of paternal lineages in populations. In this study, we conducted Y-chromosomal lineage-tracing Arabian horses. First, resolved haplotype phylogeny based on next generation sequencing data 157 males from several breeds. haplotypes specific horses were inferred by genotyping collection 145 representing most sire lines that are active around globe. These formed three discrete haplogroups, same haplogroups...
<title>Abstract</title> Livestock production systems are complex and evolve over time, affecting their adaptability to economic, political, disease-related changes. In Europe, disease resilience is crucial due threats like the African swine fever virus, which jeopardizes pork stability. The European Union identifies farm type as a key risk factor for spread, making it important track changes in types assess risk. However, detailed data often lacking national databases. For Swiss pig farms,...
Livestock production systems are complex and evolve over time, affecting their adaptability to economic, political, disease-related changes. In Europe, disease resilience is crucial due threats like the African swine fever virus, which jeopardizes pork stability. The European Union identifies farm type as a key risk factor for spread, making it important track changes in types assess risk. However, detailed data often lacking national databases. For Swiss pig farms, we used prediction...
ABSTRACT A fluorogenic PCR specific for ovine herpesvirus 2 (OvHV-2) DNA was developed and compared to a previously established conventional seminested PCR. Testing of total 152 blood samples from both positive negative animals revealed that the results assays corresponded each other in 100% cases. second genomic sheep required normalize quantity viral sample. Separate standard curves had be constructed The analytical sensitivity new PCRs ranged between at least 10 copies sometimes even 1...
Summary Genetic characterization helps to assure breed integrity and assign individuals defined populations. The objective of this study was characterize genetic diversity in six horse breeds analyse the population structure Franches‐Montagnes breed, especially with regard degree introgression Warmblood. A total 402 alleles from 50 microsatellite loci were used. average number per locus significantly lower Thoroughbreds Arabians. Average heterozygosities between ranged 0.61 0.72. overall...
Whole-genome sequencing studies are vital to gain a thorough understanding of genomic variation. Here, we summarize the results whole-genome study comprising 88 horses and ponies from diverse breeds at 19.1× average coverage. The paired-end reads were mapped current EquCab3.0 horse reference genome assembly, identified approximately 23.5 million single nucleotide variants 2.3 short indel variants. Our dataset included least 7 that not previously reported. On average, each individual carried...
Coat color and pattern variations in domestic animals are frequently inherited as simple monogenic traits, but a number known to have complex genetic basis. While the analysis of trait data remains challenge all species, we can use reduced haplotypic diversity animal populations gain insight into genomic interactions underlying phenotypes. White face leg markings examples traits horses where little is genetics. In this study, Franches-Montagnes (FM) were scored for occurrence white facial...