A5035242879- Allergic Rhinitis and Sensitization
- Veterinary Equine Medical Research
- Food Allergy and Anaphylaxis Research
- Entomological Studies and Ecology
- Asthma and respiratory diseases
- Dermatology and Skin Diseases
- Genetic and phenotypic traits in livestock
- T-cell and B-cell Immunology
- Reproductive Physiology in Livestock
- Vector-Borne Animal Diseases
- Veterinary Oncology Research
- Animal health and immunology
- Genetic diversity and population structure
- Genetic Mapping and Diversity in Plants and Animals
- Insect and Pesticide Research
- Virus-based gene therapy research
- Mast cells and histamine
- Immunotherapy and Immune Responses
- Animal Behavior and Reproduction
- Kruppel-like factors research
- Plant and fungal interactions
- Microbial infections and disease research
- Exercise and Physiological Responses
- Vector-borne infectious diseases
- Angiogenesis and VEGF in Cancer
EADA Business School
2025
University of Bern
2015-2024
Hospital Universitario 12 De Octubre
2024
Centro de Investigación Biomédica en Red de Cáncer
2024
Universidad Iberoamericana
2007-2014
Pädagogische Hochschule Bern
2010
University of Carabobo
2007
Swiss Institute of Equine Medicine
2003-2004
Animal Health Trust
1995
Summary Reasons for performing study : Endoscopic scoring of airway mucus quantity and quality has not been critically assessed. Objectives To evaluate scores 1) observer‐ horse‐related variance 2) association with inflammation, viscoelasticity measured volume. Methods Variance within between observers over time horses were determined accumulation, apparent viscosity, localisation colour, correlations accumulation neutrophil ratios in secretions. The relationship score to volumes ‘artificial...
Background : Environment and genetics influence the manifestation of recurrent airway obstruction (RAO), but associations specific factors with mild, moderate, severe clinical signs are unknown. Hypothesis We hypothesized that sire, feed, bedding, time outdoors, sex, age associated manifestations lower disease. Animals Direct offspring 2 RAO‐affected Warmblood stallions (F1S1, n = 172; F1S2, 135); maternal half‐siblings F1S1 (mHSS1, 66); an age‐matched, randomly chosen control group (CG,...
BackgroundInsect-bite hypersensitivity is the most common allergic dermatitis in horses. Excoriated skin lesions are typical symptoms of this seasonal and refractory chronic disease. On a cellular level, characterized by massive eosinophil infiltration caused an underlying response.ObjectiveTo target these cells treat disease, we developed therapeutic vaccine against equine IL-5 (eIL-5), master regulator eosinophils.MethodsThe consisted eIL-5 covalently linked to virus-like particle derived...
Allergic diseases in animals are increasingly gaining importance veterinary practice and as research models. For intradermal testing allergen immunotherapy, a good knowledge of relevant allergens for the individual species is great importance. Currently, about based on sensitization rates identified by or serum allergen-specific IgE; crude extracts basis most evaluations. Only few studies provide evidence molecular structure (particularly) dust mite, insect mould dogs horses, respectively....
Horses housed in conventional stable environments are exposed to high dust loads. Long-term exposure inhaled may lead subclinical airway disease.Airway inflammation and mucus accumulation 1) common asymptomatic well-performing sport horses, 2) increased older compared younger individuals 3) correlated.Mucus quantity quality (endoscopic scoring) BALF differential cytology were assessed 13 horses (mean age 5 years) 15 years), which had no historical or clinical evidence of lower disease,...
Summary The genetic influence on chronic hypersensitivity bronchitis (CB) was investigated in families at two studs and among half‐siblings of three affected non‐affected sires several farms. family members the were born raised under same conditions, whereas kept individually very different conditions exposed to various environmental factors. diagnosis based long‐term observations multiple clinical examinations each studs. In half‐sibling group, individual history a thorough examination. all...
Background: Environment and genetics influence the manifestation of recurrent airway obstruction (RAO), but associations specific factors with mild, moderate, severe clinical signs are unknown.Hypothesis: We hypothesized that sire, feed, bedding, time outdoors, sex, age associated manifestations lower disease.Animals: Direct offspring 2 RAO-affected Warmblood stallions (F1S1, n 5 172; F1S2, 135); maternal half-siblings F1S1 (mHSS1, 66); an age-matched, randomly chosen control group (CG,...
Summary We postulated that all horses exposed to the bites of Culcoides (midges) would have an antibody response antigen secreted in saliva, but IgE be restricted allergic individuals. Using immunohistology on sections fixed Culicoides , we demonstrated presence antibodies horse serum which recognise salivary glands. Antibodies were detected with insect dermal hypersensitivity and normal bites. In contrast, no from native Icelandic ponies had not been Culicoides. Anti‐salivary gland IgG both...
Summary Blood samples of 561 Lipizzan horses from subpopulations (studs) seven European countries representing a large fraction the breed's population were used to examine genetic diversity, subdivision and gene flow in breed. DNA analysis based on 18 microsatellite loci revealed that diversity (observed heterozygosity = 0.663, 0.675 mean number alleles 7.056) horse is similar other breeds as well domestic animal species. The differentiation between different studs, although moderate, was...
Summary Genetic characterization helps to assure breed integrity and assign individuals defined populations. The objective of this study was characterize genetic diversity in six horse breeds analyse the population structure Franches‐Montagnes breed, especially with regard degree introgression Warmblood. A total 402 alleles from 50 microsatellite loci were used. average number per locus significantly lower Thoroughbreds Arabians. Average heterozygosities between ranged 0.61 0.72. overall...
Summary Recurrent airway obstruction (RAO) is a common condition in stabled horses characterized by small inflammation, neutrophilia and following exposure of susceptible to mouldy hay straw thus regarded as hypersensitivity reaction mould spores. However, the role immunoglobulin E antibodies (IgE) pathogenesis RAO unclear. We hypothesized that number cells with receptor‐bound IgE bronchoalveolar lavage fluid (BALF) levels serum would be higher RAO‐affected than healthy living same...
Insect bite hypersensitivity (IBH) is the most common seasonal pruritic allergic dermatitis of horses occurring upon insect bites. In recent years, a major role for IL-31 in pruritus humans, monkeys, dogs, and mice was acknowledged. Here, we investigate IBH developed therapeutic vaccine against equine (eIL-31).IL-31 levels were quantified allergen-stimulated peripheral blood mononuclear cells (PBMCs) skin punch biopsies lesions healthy from IBH-affected horses. The consisted eIL-31...
Abstract Adverse reactions to insects occur in both human and veterinary patients. Systematic comparison may lead improved recommendations for prevention treatment all species. In this position paper, we summarize the current knowledge on insect allergy induced via stings, bites, inhalation or ingestion, compare companion animals those people. With few exceptions, situation is better documented than animals. We focus a review of recent literature give overviews epidemiology clinical signs....