A5085398845- Genetic and phenotypic traits in livestock
- Social and Educational Sciences
- Veterinary Equine Medical Research
- Genetic Mapping and Diversity in Plants and Animals
- Animal Genetics and Reproduction
- Genetics and Physical Performance
- melanin and skin pigmentation
- Molecular Biology Techniques and Applications
- Gender, Labor, and Family Dynamics
- Migration and Labor Dynamics
- Meat and Animal Product Quality
- Genetic diversity and population structure
- Food Allergy and Anaphylaxis Research
- Entomological Studies and Ecology
- Muscle Physiology and Disorders
- Animal Nutrition and Physiology
- Genomics and Chromatin Dynamics
- Dermatology and Skin Diseases
- Muscle metabolism and nutrition
- Poverty, Education, and Child Welfare
- Identification and Quantification in Food
- Sarcoma Diagnosis and Treatment
- Early Childhood Education and Development
- Social Policy and Reform Studies
- Plant and fungal interactions
University of Gothenburg
2014-2024
Uppsala University
2003-2024
Karolinska Institutet
2024
Swedish University of Agricultural Sciences
2008-2023
Stockholm University
2018-2022
United Nations University – Maastricht Economic and Social Research Institute on Innovation and Technology
2020
Organisation de Coopération et de Développement Economiques
2018
Science for Life Laboratory
2016
KU Leuven
2016
University of Helsinki
2015
Locomotion in mammals relies on a central pattern-generating circuitry of spinal interneurons established during development that coordinates limb movement. These networks produce left-right alternation limbs as well coordinated activation flexor and extensor muscles. Here we show premature stop codon the DMRT3 gene has major effect pattern locomotion horses. The mutation is permissive for ability to perform alternate gaits favourable harness racing performance. Examination wild-type...
Intense selective pressures applied over short evolutionary time have resulted in homogeneity within, but substantial variation among, horse breeds. Utilizing this population structure, 744 individuals from 33 breeds, and a 54,000 SNP genotyping array, breed-specific targets of selection were identified using an FST-based statistic calculated 500-kb windows across the genome. A 5.5-Mb region ECA18, which myostatin (MSTN) gene was centered, contained highest signature both Paint Quarter...
Horses were domesticated from the Eurasian steppes 5,000–6,000 years ago. Since then, use of horses for transportation, warfare, and agriculture, as well selection desired traits fitness, has resulted in diverse populations distributed across world, many which have become or are process becoming formally organized into closed, breeding (breeds). This report describes a genome-wide set autosomal SNPs 814 36 breeds to provide first detailed description equine breed diversity. FST calculations,...
We test for gender, class, and ethnic discrimination in the Norwegian rental housing market by using fake application letters. Females, individuals with high job status, Norwegians are more likely to receive positive responses. For example, being an Arabic man working a warehouse is associated 25 percentage point lower probability of receiving response when showing interest apartment, as compared ethnically female economist. conclude that do exist market, seems be most prevalent form...
Equine Multiple Congenital Ocular Anomalies (MCOA) syndrome is a heritable eye disorder mainly affecting silver colored horses. Clinically, the disease manifests in two distinct classes depending on horse genotype. Horses homozygous for mutant allele present with wide range of ocular defects, such as iris stromal hypoplasia, abnormal pectinate ligaments, megaloglobus, iridociliary cysts and cataracts. The phenotype heterozygous horses less severe predominantly includes cysts, which...
Insect bite hypersensitivity (IBH) is a chronic allergic dermatitis common in horses. Affected horses mainly react against antigens present the saliva from biting midges, Culicoides ssp, and occasionally black flies, Simulium ssp. Because of this insect dependency, disease clearly seasonal prevalence varies between geographical locations. For two distinct horse breeds, we genotyped four microsatellite markers positioned within MHC class II region sequenced highly polymorphic exons DRA DRB3,...
Multiple congenital ocular anomalies (MCOA) syndrome is a hereditary eye defect that was first described in Silver colored Rocky Mountain horses. The mutation causing this disease located within defined chromosomal interval, which also contains the gene and associated with coat color (PMEL17, exon 11). Horses are homozygous for disease-causing allele have multiple defects (MCOA-phenotype), whilst heterozygous horses predominantly cysts of iris, ciliary body or retina (Cyst-phenotype). It has...
Abstract Skeletal atavism in Shetland ponies is a heritable disorder characterized by abnormal growth of the ulna and fibula that extend carpal tarsal joints, respectively. This causes skeletal structure impaired movements, affected foals are usually killed. In order to identify causal mutation we subjected six confirmed Swedish cases DNA pool consisting 21 control individuals whole genome resequencing. We screened for polymorphisms where were fixed opposite alleles observed this signature...
FET fusion oncoproteins containing one of the (FUS, EWSR1, TAF15) family proteins juxtaposed to alternative transcription‐factor partners are characteristic more than 20 types sarcoma and leukaemia. bind SWI/SNF chromatin remodelling complex, which exists in three subtypes: cBAF, PBAF GBAF/ncBAF. We used comprehensive biochemical analysis characterize interactions between oncoproteins, complexes transcriptional coactivator BRD4. Here, we report that all main subtypes GBAF, interact...
Abstract Background Equine Multiple Congenital Ocular Anomalies (MCOA) syndrome consists of a diverse set abnormalities predominantly localized to the frontal part eye. The disease is in agreement with codominant mode inheritance our horse material. Animals presumed be heterozygous for mutant allele have cysts originating from temporal ciliary body, peripheral retina and/or iris. In contrast, animals predicted homozygous disease-causing possess wide range multiple abnormalities, including...
Over the past decades, Europe has seen increasing interest in and pressure to coordinate social policy. Studies on coordination of policies have found that institutional settings affect patterns when comparing different welfare state ideal-types. Adding this body research, paper compares two countries with diverging authority regulate policy areas; Sweden representing a unitary decentralized UK regionalized state. With labour market programs for youth serving as case, purpose is compare...
Myxoid liposarcoma is one of the most common sarcoma entities characterized by FET fusion oncogenes. Despite a generally favorable prognosis myxoid liposarcoma, chemotherapy resistance remains clinical problem. This cancer stem cell property associated with JAK-STAT signaling, but link to myxoid-liposarcoma-specific oncogene FUS-DDIT3 not known. Here, we show that ectopic expression resulted in elevated levels STAT3 and phosphorylated STAT3. RNA sequencing identified 126 genes were regulated...
Symmetrical lupoid onychodystrophy (SLO) is an immune-mediated disease in dogs affecting the claws with a suggested autoimmune aethiology. Sequence-based genotyping of polymorphic exon 2 from DLA-DRB1, -DQA1, and -DQB1 class II loci were performed total 98 SLO Gordon setter cases healthy controls. A risk haplotype (DRB1*01801/DQA1*00101/DQB1*00802) was present 53% 34% controls conferred elevated developing odds ratio (OR) 2.1. When homozygous for compared to all not carrying OR 5.4. However,...
Previous studies showed a positive effect of the DMRT3 “gait keeper” mutation on harness racing performance in Standardbreds, French-, and Nordic trotters. The has also been shown to influence riding traits multiple breeds. This study investigated Finnhorses. Finnhorses used for ( n = 180) 59) were genotyped mutation. For trotters genotypes evaluated association with (number starts, victories, placings, earnings, race times). At 3–6 years age AA genotype was superior compared CA CC...
Insect bite hypersensitivity (IBH) is the most common allergic skin disease in horses and caused by biting midges, mainly of genus Culicoides. The predominantly comprises a type I reaction, causing severe itching discomfort that reduce welfare commercial value horse. It multifactorial disorder influenced both genetic environmental factors, with heritability ranging from 0.16 to 0.27 various horse breeds. worldwide prevalence different breeds ranges 3% 60%; it more than 50% Icelandic exported...
The purpose of this paper is to better understand the relationship between migration and multi-dimensional well-being in context Ethiopia. We investigate differences migrant, non-migrant return migrant households. then go a step further role migrants destinations for by disaggregating destination Middle East, Africa North. find that households are off terms than Furthermore, findings underline importance taking into account determining wellbeing left behind. While with North significantly...
DDIT3 is a tightly regulated basic leucine zipper (bZIP) transcription factor and key regulator in cellular stress responses. It involved variety of pathological conditions may cause cell cycle block apoptosis. also implicated differentiation some specialized types as an oncogene several cancer. was originally believed to act dominant-negative inhibitor by forming heterodimers with other bZIP factors, preventing their DNA binding transactivating functions. has, however, been reported bind...
Summary Grey horses are born coloured, turn progressively grey and often develop melanomas late in life. shows an autosomal dominant inheritance the locus has previously been mapped to horse chromosome 25 (ECA25), around TXN gene. We have now developed eight new single nucleotide polymorphisms (SNPs) associated with genes on ECA25 using information linear order of human 9q, as well mouse coding sequences. These SNPs were relation more than 300 progeny from matings between two Swedish...
Summary The Icelandic horse is a breed known mainly for its ability to perform the ambling four‐beat gait ‘tölt’ and lateral two‐beat pace. natural of these alternative gaits highly desired by breeders. Therefore, discovery that nonsense mutation (C>A) in DMRT 3 gene was main genetic factor horses' addition walk, trot canter great interest. Although several studies have demonstrated homozygosity important pace, only about 70% homozygous mutant ( AA ) horses are reported aim study...