A5090512122- Breast Cancer Treatment Studies
- HER2/EGFR in Cancer Research
- Breast Lesions and Carcinomas
- Cancer Risks and Factors
- Estrogen and related hormone effects
- Advanced Breast Cancer Therapies
- Entomological Studies and Ecology
- Global Cancer Incidence and Screening
- Food Allergy and Anaphylaxis Research
- Cancer Treatment and Pharmacology
- Veterinary Equine Medical Research
- Insect and Pesticide Research
- Vector-Borne Animal Diseases
- Cancer Cells and Metastasis
- Molecular Biology Techniques and Applications
- Gene expression and cancer classification
- Plant and fungal interactions
- Cancer Diagnosis and Treatment
- Dermatology and Skin Diseases
- Carcinogens and Genotoxicity Assessment
- Nutritional Studies and Diet
- Allergic Rhinitis and Sensitization
- Cancer-related Molecular Pathways
- Science, Research, and Medicine
- Melanoma and MAPK Pathways
Landstinget i Kalmar län
2002-2023
Norrköping Hospital
2015
Wageningen University & Research
2015
Swedish University of Agricultural Sciences
2015
Nottingham City Hospital
2009-2010
Sahlgrenska University Hospital
2010
Insect bite hypersensitivity (IBH) is a chronic allergic dermatitis common in horses. Affected horses mainly react against antigens present the saliva from biting midges, Culicoides ssp, and occasionally black flies, Simulium ssp. Because of this insect dependency, disease clearly seasonal prevalence varies between geographical locations. For two distinct horse breeds, we genotyped four microsatellite markers positioned within MHC class II region sequenced highly polymorphic exons DRA DRB3,...
There is a lack of knowledge about the genetic background eczema due to insect bite hypersensitivity, also called summer eczema, in horses. The condition known several horse breeds and countries it causes reduced welfare economic losses owner. aim this study was estimate parameters for Swedish-born Icelandic A questionnaire sent owners horses sired by stallions with more than 50 offspring born Sweden between 1991 2001. Variance components classified as healthy, mild, moderate or severe were...
Insect bite hypersensitivity (IBH) is the most common allergic skin disease in horses and caused by biting midges, mainly of genus Culicoides. The predominantly comprises a type I reaction, causing severe itching discomfort that reduce welfare commercial value horse. It multifactorial disorder influenced both genetic environmental factors, with heritability ranging from 0.16 to 0.27 various horse breeds. worldwide prevalence different breeds ranges 3% 60%; it more than 50% Icelandic exported...
Abstract Equine insect bite hypersensitivity (IBH) is a pruritic skin allergy caused primarily by biting midges, Culicoides spp. IBH susceptibility has polygenic inheritance and occurs at high frequencies in several horse breeds worldwide, causing increased costs reduced welfare of affected horses. The aim this study was to identify validate single nucleotide polymorphisms (SNPs) associated with equine susceptibility. After quality control, 33,523 SNPs were included Bayesian genome‐wide...
A common approach in exploring register data is to find relationships between outcomes and predictors by using multiple regression analysis (MRA). If there more than one outcome variable, the must then be repeated, results combined some arbitrary fashion. In contrast, Canonical Correlation Analysis (CCA) has ability analyze at same time. One essential after breast cancer treatment recurrence of disease. It important understand relationship different recurrence, including time interval until...
Several studies suggest that total breastfeeding time reduces breast cancer risk. The underlying mechanisms are unclear. Whether also affects the prognosis is not yet investigated. A number of tumour characteristics, i.e. histological type cancer, grade, size, Nottingham prognostic index, vascular invasion and DNA-ploidy, have been demonstrated to be value.We searched for a possible link between these markers time, age at first child children. 250 women treated answered questionnaire.No...
To study whether breastfeeding affects survival from breast cancer.There are few studies on the relationship between breastfeeding, reproductive health, and cancer survival. This is a follow-up of an earlier showing no convincing associations prognostic parameters.From cohort 629 women with primary having undergone surgery 1988 1992, 341 were traced consequently studied 20 years later regarding variables, as well for parameters such Nottingham histological grade, tumor size, lymph node...
When ipsilateral multifocal primary breast cancer (IMBC) is detected, standard routine to evaluate the largest tumor with immunohistochemistry (IHC). As all foci are not routinely characterized, many patients may receive optimal adjuvant treatment. Here, we assess clinical relevance of examining at least two present in IMBC.Patients diagnosed and treated for IMBC Sahlgrenska University Hospital (Gothenburg, Sweden) between 2012 2017 were screened. In total, 180 ≥ 2 invasive (183 specimens)...
Trastuzumab has markedly improved the treatment and long‑term prognosis of patients with HER2‑positive breast cancer. A frequent clinical challenge in relapsing and/or metastatic disease is de novo or acquired trastuzumab resistance, to date no predictive biomarkers for palliative have been established. In present study, prognostic values factors involved HER2‑associated PI3K/Akt signalling pathway were explored. The first 46 consecutive treated at Department Oncology, Linköping University...
Abstract Clinical decision-making for patients with breast cancer (BC) is still primarily based on biomarker characteristics of the primary tumor, together evaluation synchronous axillary lymph node metastasis (LNM). In this study, we investigated prevalence discordance in biomarkers and surrogate subtyping between BC LNM, whether subsequent changes would have altered clinical treatment recommendations. retrospective 94 treated unifocal LNM at Sahlgrenska UniversityHospital during 2018 were...
The extent of apoptosis and the expression Bcl-2 was investigated in tumor samples from 165 women who underwent surgery for primary breast carcinoma between 1989 1990 South-East Sweden. Apoptosis assessed by a DNA fragmentation assay flow cytometry. protein analyzed with immunocytochemistry immunoreactivity correlated estrogen receptor (ER) progesterone (PgR) positivity inversely p53 accumulation. increased patient age high degree negatively associated immunostaining. showed no significant...
Purpose. Continuous minor steps of improvement in the management breast cancer have resulted decreased mortality rates during last decades. The aim this study was to compare clinical outcome patients with stage I diagnosed two time periods that differed respect adjuvant systemic therapy. Material and methods. studied population consisted all women < 60 years age, who were between 1986 1999 south-east Sweden, a total 1 407 cases. cohort divided into groups based on programmes 1992, hereafter...