A5017080074- Gut microbiota and health
- Diet and metabolism studies
- Tryptophan and brain disorders
- Dietary Effects on Health
- Microbial Metabolites in Food Biotechnology
- Health, Medicine and Society
- Liver Disease Diagnosis and Treatment
- Tea Polyphenols and Effects
- Psychoanalysis and Psychopathology Research
- Digestive system and related health
- Gastrointestinal motility and disorders
- Immune Cell Function and Interaction
- Probiotics and Fermented Foods
- Clinical Nutrition and Gastroenterology
- Clostridium difficile and Clostridium perfringens research
- Nutritional Studies and Diet
- Metabolomics and Mass Spectrometry Studies
- Mycotoxins in Agriculture and Food
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Carcinogens and Genotoxicity Assessment
- Receptor Mechanisms and Signaling
- Genomics, phytochemicals, and oxidative stress
- Phytochemicals and Antioxidant Activities
- Social Policies and Family
- Neuropeptides and Animal Physiology
AgroParisTech
2012-2025
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2020-2025
Université Paris-Saclay
2016-2025
Microbiologie de l’alimentation au service de la santé
2016-2025
Institut National de la Recherche Agronomique d'Algérie
2019
Institut National de la Recherche Agronomique
2004-2019
Département Génétique Animale
2017
Interdisciplinarité en Santé Publique Interventions et Instruments de mesure complexes – Région Est
2012-2013
Virologie et Immunologie Moléculaires
1990-2010
Laboratoire de Chimie Bactérienne
2007
<h3>Objective</h3> Non-alcoholic fatty liver disease (NAFLD) is prevalent among obese people and considered the hepatic manifestation of metabolic syndrome. However, not all individuals develop NAFLD. Our objective was to demonstrate role gut microbiota in NAFLD development using transplantation experiments mice. <h3>Design</h3> Two donor C57BL/6J mice were selected on basis their responses a high-fat diet (HFD). Although both displayed similar body weight gain, one mouse, called...
Abstract Background The intestinal mucus layer plays a key role in the maintenance of host-microbiota homeostasis. To document crosstalk between host and microbiota, we used gnotobiotic models to study influence two major commensal bacteria, Bacteroides thetaiotaomicron Faecalibacterium prausnitzii, on this layer. B. is known use polysaccharides from mucus, but its effect goblet cells has not been addressed so far. F. prausnitzii particular physiological importance because it can be...
Gut microbiota richness and stability are important parameters in host-microbe symbiosis. Diet modification, notably using dietary fibres, might be a way to restore high the gut microbiota. In this work, during 6-week nutritional trial, 19 healthy adults consumed basal diet supplemented with 10 or 40 g fibre per day for 5 days, followed by 15-day washout periods. Fecal samples were analysed combination of 16S rRNA gene pyrosequencing, intestinal cell genotoxicity assay, metatranscriptomics...
Gut microbiota produces a wide and diverse array of metabolites that are an integral part the host metabolome. The emergence gut microbiome-brain axis concept has prompted investigations on role dysbioses in pathophysiology brain diseases. Specifically, search for microbe-related metabolomic signatures human patients animal models psychiatric disorders pointed out importance microbial metabolism aromatic amino acids. Here, we investigated effect indole behavior rats. Indole is produced by...
ABSTRACT Lignans are dietary diphenolic compounds which require activation by intestinal bacteria to exert possible beneficial health effects. The ecosystem plays a crucial role in lignan metabolism, but the organisms involved poorly described. To characterize bacterial communities responsible for secoisolariciresinol (SECO) activation, i.e., that produce enterolignans enterodiol (ED) and enterolactone (EL), study with 24 human subjects was undertaken. SECO detected all tested fecal samples....
Non-alcoholic fatty liver disease (NAFLD) affects about 20-40% of the adult population in high-income countries and is now a leading indication for transplantation can lead to hepatocellular carcinoma. The link between gut microbiota dysbiosis NAFLD clearly established. Through analyses with shotgun metagenomics, we observe that compared healthy controls, Adlercreutzia equolifaciens depleted patients diseases such as NAFLD. Its abundance also decreases progresses eventually disappears last...
Cruciferous vegetables, such as Brassica, which contain substantial quantities of glucosinolates, have been suggested to possess anticarcinogenic activity. Cutting and chewing cruciferous vegetables releases the thioglucosidase enzyme myrosinase, degrades glucosinolates isothiocyanates other minor metabolites. Cooking inactivates myrosinase enzyme, allowing intact reach large intestine, where they can be degraded by indigenous microflora into isothiocyanates. This local release may explain...
Non-alcoholic fatty liver diseases (NAFLD) are associated with changes in the composition and metabolic activities of gut microbiota. However, causal role played by microbiota individual susceptibility to NAFLD particularly at its early stage is still unclear. In this context, we transplanted from a patient (NAFL) healthy two groups mice. We first showed that recipient mice resembled their respective human donor. Following administration high-fructose, high-fat diet, received NAFL (NAFLR)...
Intestinal inflammation shifts microbiota composition and metabolism. How the host monitors responds to such changes remains unclear. Here, we describe a protective mechanism by which mucosal-associated invariant T (MAIT) cells detect metabolites produced upon intestinal promote tissue repair. At steady state, MAIT ligands derived from riboflavin biosynthesis pathway were aerotolerant bacteria residing in colonic mucosa. Experimental colitis triggered luminal expansion of...
In addition to their use in cheese technology, dairy propionibacteria have been identified as potential probiotics. However, a probiotic effect, survive and remain metabolically active the digestive tract. The aim of present study was investigate survival metabolic activity Propionibacterium freudenreichii within gastrointestinal tract human microbiota-associated rats, its influence on intestinal microbiota composition metabolism. Twenty-five strains were screened for tolerance towards...
Current fructose consumption levels often overwhelm the intestinal capacity to absorb fructose. We investigated impact of malabsorption on endocrine function and addressed role microbiota in this process. To answer question, a mouse model moderate [ketohexokinase mutant (KHK)−/−] wild-type (WT) littermate mice were used received 20%-fructose (KHK-F WT-F) or 20%-glucose diet. Cholecystokinin (Cck) mRNA protein expression ileum cecum, as well preproglucagon (Gcg) neurotensin (Nts) increased...
Several factors are linked to the pathophysiology of autism spectrum disorders (ASD); however, molecular mechanisms condition remain unknown. As intestinal problems and gut microbiota dysbiosis associated with ASD development severity, recent studies have focused on elucidating microbiota-gut-brain axis' involvement. This study aims explore through which might influence ASD. Briefly, we depleted conventional male BALB/cAnNCrl (Balb/c) C57BL/6J (BL/6) mice prior human fecal transplantation...
Propionibacterium freudenreichii , a food-grade bacterium able to kill colon cancer cell lines in vitro by apoptosis, may exert an anticarcinogenic effect vivo . To assess this hypothesis, we administered daily 2 × 10 colony-forming units (CFU) of P. TL133 human microbiota-associated (HMA) rats for 18 d. Either saline or 1,2-dimethylhydrazine (DMH) was also on days 13 and 17 were killed day 19. The levels apoptosis proliferation the mid distal assessed terminal deoxynucleotide...
An integrated analysis of gut microbiota, blood biochemical and metabolome in 52 endurance horses was performed. Clustering by microbiota revealed the existence two communities mainly driven diet as host properties showed little effect. Community 1 presented lower richness diversity, but higher dominance rarity species, including some pathobionts. Moreover, its composition tightly linked to metabolites related lipid metabolism glycolysis at basal time. Despite fiber intake, community type...
Interactions of diet, gut microbiota, and host genetics play essential roles in the development metabolic diseases. A/J C57BL/6J (C57) are two mouse strains known to display different susceptibilities disorders. In this context, we analyzed microbiota composition C57 mice, assessed its responses high-fat diet (HFD) antibiotic (AB) treatment. We also exchanged between following AB treatment evaluate impact on metabolism. showed that mice have microbiome structure at baseline. Moreover,...
Bacterial colonization in the gut plays a pivotal role neonatal necrotizing enterocolitis (NEC) development, but relationship between bacteria and NEC remains unclear. In this study, we aimed to elucidate whether bacterial butyrate end-fermentation metabolites participate development of lesions confirm enteropathogenicity Clostridium butyricum neonatale NEC. First, produced C.butyricum C.neonatale strains impaired production by genetically inactivating hbd gene encoding β-hydroxybutyryl-CoA...
Chronic stress and the gut microbiota appear to comprise a feed-forward loop, which contributes development of depressive disorders. Evidence suggests that memory can also be impaired by either chronic or imbalance. However, it remains established whether these could part an integrated loop model responsible for impairments. To shed light on this, we used two-pronged approach in Japanese quail: first stress-induced alterations were characterized, then tested this altered affect brain...
Gut microbiota metabolizes tryptophan into indole, which can influence brain and behavior. Indeed, some oxidized derivatives of formed in the liver, have neuroactive properties, indole overproduction by gut induces an anxio-depressive phenotype rodents. The aim this study was to investigate humans whether there a relationship between recurrent depressive symptoms production microbiota. A case-control conducted 45–65-year-old women, who were participants observational prospective...
Regular and moderate wine consumption is one of the explanations suggested for lower incidence cardiovascular events in France compared with other industrialized countries. We evaluated whether alcohol alone or combined red polyphenols reduced plaque size and/or attenuated thrombotic reactivity at site advanced atherosclerotic lesions. Red extract, purified (+)-catechin alcohol, alone, was added 12 weeks to drinking water apoE-deficient (apoE(-/-)) C57BL/6 mice wild-type counterparts. In...
Scope Protein malnutrition is characterized by stunted growth, hepatic steatosis and a damaged gut mucosal architecture. Since high‐fat shaped microbiota (HFM) has an increased ability in providing nutrients energy from food to the host, aim of this study determine whether such could beneficially impact on consequences malnutrition. Methods results The cecal content specific pathogen free C57Bl/6J mice fed diet or low‐protein transplanted two groups germ‐free recipient mice, which are...
In poultry, the selection of broilers for growth performance has induced a deterioration in health parental hens associated with poor reproductive efficiency. To improve these parameters, we administered to laying broiler regular diet supplemented or not (Control) moderate (1%) high level (2%) grape seed extract (GSE). The 1% GSE was from young age (from 4 40 weeks age) and 2% only during 2-week period 38 period. analysis 40-week-old showed that displayed reduction fat tissue an improvement...