A5021488748- Gut microbiota and health
- Diet and metabolism studies
- Diet, Metabolism, and Disease
- Pancreatic function and diabetes
- Clostridium difficile and Clostridium perfringens research
- Enzyme Production and Characterization
- Inflammatory Bowel Disease
- Enzyme Structure and Function
- Dietary Effects on Health
- Peptidase Inhibition and Analysis
- Protease and Inhibitor Mechanisms
- Probiotics and Fermented Foods
- Infant Nutrition and Health
- Digestive system and related health
- Gastrointestinal motility and disorders
- Oral and gingival health research
- Phytase and its Applications
- Biochemical and Molecular Research
- Protein Hydrolysis and Bioactive Peptides
- Helicobacter pylori-related gastroenterology studies
- Enzyme Catalysis and Immobilization
- DNA and Nucleic Acid Chemistry
- Tryptophan and brain disorders
- Protein Structure and Dynamics
- Adenosine and Purinergic Signaling
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2020-2024
Microbiologie de l’alimentation au service de la santé
2015-2024
AgroParisTech
2014-2024
Université Paris-Saclay
2017-2024
Université Claude Bernard Lyon 1
2008-2023
Centre National de la Recherche Scientifique
2008-2023
Interdisciplinarité en Santé Publique Interventions et Instruments de mesure complexes – Région Est
2012-2020
Multidisciplinary Digital Publishing Institute (Switzerland)
2019
Universidad Complutense de Madrid
2019
Centre de Biologie Structurale
2013
Gut microbiota produces a wide and diverse array of metabolites that are an integral part the host metabolome. The emergence gut microbiome-brain axis concept has prompted investigations on role dysbioses in pathophysiology brain diseases. Specifically, search for microbe-related metabolomic signatures human patients animal models psychiatric disorders pointed out importance microbial metabolism aromatic amino acids. Here, we investigated effect indole behavior rats. Indole is produced by...
Abstract Background Management of blood cholesterol is a major focus efforts to prevent cardiovascular diseases. The objective this study was investigate how the gut microbiota affects host homeostasis at organism scale. Results We depleted intestinal hypercholesterolemic female Apoe −/− mice using broad-spectrum antibiotics. Measurement plasma levels as well synthesis and fluxes by complementary approaches showed that strongly regulates level, hepatic synthesis, enterohepatic circulation....
Alterations in gut microbiota composition and diversity were suggested to play a role the development of obesity, chronic subclinical inflammatory condition. We here evaluated impact oral consumption monostrain or multi-strain probiotic preparation high-fat diet-induced obese mice. observed strain-specific effect reported dissociation between capacity probiotics dampen adipose tissue inflammation limit body weight gain. A mixture was able improve adiposity, insulin resistance dyslipidemia...
Increasing evidence suggests that polyphenols have a significant potential in the prevention and treatment of risk factors associated with metabolic syndrome. The objective this study was to assess outcomes two polyphenol-containing extracts from cinnamon bark (CBE) grape pomace (GPE) on C57BL/6J mice fed high-fat diet (HFD) for 8 wk. Both CBE GPE were able decrease fat mass gain adipose tissue inflammation HFD without reducing food intake. This reduced liver steatosis lower plasma...
Abstract Obesity is associated with low-grade chronic inflammation promoting insulin-resistance and diabetes. Gut microbiota dysbiosis a consequence as well driver of obesity Mucosal-associated invariant T cells (MAIT) are innate-like expressing semi-invariant cell receptor restricted to the non-classical MHC class I molecule MR1 presenting bacterial ligands. Here we show that during MAIT promote in both adipose tissue ileum, leading insulin resistance impaired glucose lipid metabolism. act...
Glyphosate is found in a large array of non-selective herbicides such as Roundup® (Monsanto, Creve Coeur, MO, USA) and by far the most widely used herbicide. Recent work rodent models suggests that glyphosate-based during development can affect neuronal communication result altered behaviours, albeit through undefined mechanisms action. To our knowledge, no study has investigated effects glyphosate or its formulation herbicide on maternal behaviour physiology. In present study, relatively...
Serine proteases are extensively known to play key roles in many physiological processes. However, their dysregulation is often associated several diseases including inflammatory bowel (IBD). Here, we used specific substrates monitor fecal protease activities a large cohort of healthy and IBD patients. Of interest, serine activity was 10-fold higher samples compared controls. Moreover, functional analysis these proteolytic revealed that the most increased trypsin-like, elastase-like...
Core tip:The article is an in-depth review of the state art molecular recognition processes involving hybrid nanoparticles and bio-molecular substrates.We describe methods preparation physical characterization.The capping by proteins, DNA, peptides supramolecular assemblies, including cyclodextrins, calix[n]arenes, cucurbitales, dendrimers crown ethers then discussed.There a large analysis interactions these systems with various substrates, such as complimentary oligo-nucleotides,...
Background Membrane proteins are privileged pharmaceutical targets for which the development of structure-based drug design is challenging. One underlying reason fact that detergents do not stabilize membrane domains as efficiently natural lipids in membranes, often leading to a partial complete loss activity/stability during protein extraction and purification preventing crystallization an active conformation. Methodology/Principal Findings Anionic calix[4]arene based (C4Cn, n = 1–12) were...
Abstract Intestinal epithelium development is dramatically impaired in germfree rodents, but the consequences of absence microbiota have been overlooked other epithelia. In present study, we first description bacterial communities associated with olfactory and explored differences characteristics between conventional, specific pathogen-free, mice. While anatomy was not significantly different, observed a thinner cilia layer along decreased cellular turn-over Using electro-olfactogram,...
"Candidatus Arthromitus" sp. strain SFB-mouse-NL (SFB, segmented filamentous bacteria) is a commensal bacterium necessary for inducing the postnatal maturation of homeostatic innate and adaptive immune responses in mouse gut. Here, we report genome sequence this bacterium, which sets it apart from earlier sequenced SFB isolates.
Abstract Clinical and animal studies have demonstrated beneficial effects of early consumption dairy lipids a probiotic, Lactobacillus fermentum (Lf), on infant gut physiology. The objective this study was to investigate their long-term microbiota host entero-insular axis metabolism. Piglets were suckled with milk formula containing only plant (PL), half-half mixture (DL), or supplemented Lf (DL + Lf). They weaned standard diet challenged high-energy until postnatal day 140. DL modulated...
The role of the gut microbiota in health and disease is well recognized dysbiosis observed many chronic diseases became a new therapeutic target. challenge to get better insight into functionality commensal bacteria use this knowledge select live biotherapeutics as preventive or products. In study, we set up screening approach evaluate functional capacities 21 strains isolated from neonates adults. For purpose, selected key biological processes involved microbiome-host symbiosis known impact...
Since alterations of the gut microbiota have been shown to play a major role in obesity, probiotics attracted attention. Our aim was identify probiotic candidates for management obesity using combination vitro and vivo approaches. We evaluated ability 23 strains limit lipid accumulation adipocytes enhance secretion satiety-promoting peptide enteroendocrine cells. Following screening, selected were further investigated vivo, single, or as mixtures, murine model diet-induced obesity. Strain...