A5037367955- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- Clinical Nutrition and Gastroenterology
- T-cell and B-cell Immunology
- Gut microbiota and health
- Diabetes and associated disorders
- Immune cells in cancer
- Wound Healing and Treatments
Université Paris Sciences et Lettres
2019-2024
Inserm
2019-2024
Institut Curie
2019-2024
Immunité et Cancer
2023-2024
Commensals rule the MAITrix Mucosal-associated invariant T (MAIT) cells play an important role in mucosal homeostasis. MAIT recognize microbial small molecules presented by major histocompatibility complex class Ib molecule MR1. are absent germ-free mice, and mechanisms which microbiota control cell development unknown (see Perspective Oh Unutmaz). Legoux et al. show that, of within thymus is governed bacterial product 5-(2-oxopropylideneamino)-6- d -ribitylaminouracil, rapidly traffics from...
Tissue repair processes maintain proper organ function following mechanical or infection-related damage. In addition to antibacterial properties, mucosal associated invariant T (MAIT) cells express a tissue transcriptomic program and promote skin wound healing when expanded. Herein, we use human-like mouse model of full-thickness excision assess the underlying mechanisms MAIT cell function. Single-cell RNA sequencing analysis suggested that already at steady state. Following excision,...
Mucosal-associated invariant T (MAIT) cells harbor evolutionarily conserved TCRs, suggesting important functions. As human and mouse MAIT functional programs appear distinct, the features remain unidentified. Using species-specific tetramers coupled to single-cell RNA sequencing, we characterized cell development in six species spanning 110 million years of evolution. Cross-species analyses revealed transcriptional events underlying maturation, marked by ZBTB16 induction all species. human,...
Intestinal inflammation shifts microbiota composition and metabolism. How the host monitors responds to such changes remains unclear. Here, we describe a protective mechanism by which mucosal-associated invariant T (MAIT) cells detect metabolites produced upon intestinal promote tissue repair. At steady state, MAIT ligands derived from riboflavin biosynthesis pathway were aerotolerant bacteria residing in colonic mucosa. Experimental colitis triggered luminal expansion of...
Tissue repair processes maintain proper organ function following mechanical or infection‑related damage. In addition to anti-bacterial properties, MAIT cells express a tissue transcriptomic program and promote skin wound healing when expanded. Herein, we use human‑like full‑thickness excision mouse model assess the underlying mechanisms of cell function. Single-cell RNAseq analysis suggests that already at steady state. Following excision, keratinocyte proliferation thereby accelerating...