A5077903137- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Neuropeptides and Animal Physiology
- Pain Mechanisms and Treatments
- Neonatal and fetal brain pathology
- Parkinson's Disease Mechanisms and Treatments
- Pharmacological Receptor Mechanisms and Effects
- Tryptophan and brain disorders
- Memory and Neural Mechanisms
- Diet and metabolism studies
- Schizophrenia research and treatment
- Preterm Birth and Chorioamnionitis
- Infant Development and Preterm Care
- Cholinesterase and Neurodegenerative Diseases
- Stress Responses and Cortisol
- Infant Health and Development
- Blood Coagulation and Thrombosis Mechanisms
- Bipolar Disorder and Treatment
- Anesthesia and Neurotoxicity Research
- Nerve injury and regeneration
- Genetic Associations and Epidemiology
- Regulation of Appetite and Obesity
- Biochemical Analysis and Sensing Techniques
- Natural Compound Pharmacology Studies
Génomique du cancer et du cerveau
2022
Inserm
2013-2022
Université de Rouen Normandie
1995-2020
Biotherapy of Genetic Diseases, Inflammatory Disorders and Cancers
2018
Centre National de la Recherche Scientifique
1989-2017
Normandie Université
2017
Neurosciences Paris-Seine
2017
Sorbonne Université
2017
Centre Hospitalier Universitaire Amiens-Picardie
2017
Institute for Research and Innovation in Biomedicine
2010-2014
Current fructose consumption levels often overwhelm the intestinal capacity to absorb fructose. We investigated impact of malabsorption on endocrine function and addressed role microbiota in this process. To answer question, a mouse model moderate [ketohexokinase mutant (KHK)−/−] wild-type (WT) littermate mice were used received 20%-fructose (KHK-F WT-F) or 20%-glucose diet. Cholecystokinin (Cck) mRNA protein expression ileum cecum, as well preproglucagon (Gcg) neurotensin (Nts) increased...
Ketamine, a non-competitive N-methyl-D-aspartate (NMDA) antagonist, widely used as an anesthetic in neonatal pediatrics, is also illicit drug named Super K or KitKat consumed by teens and young adults. In the immature brain, despite several studies indicating that NMDA antagonists are neuroprotective against excitotoxic injuries, there more evidence these molecules exert deleterious effect suppressing trophic function of glutamate. present study, we show using Gad67-GFP mice prenatal...
Gastric electrical stimulation (GES) is a new therapeutic option for functional dyspepsia and gastroparesis. In addition to ameliorating nausea vomiting, GES results in improved appetite which not always associated with accelerated gastric emptying. To explore the central peripheral factors underlying GES-associated improvement of we developed model anaesthetized Wistar rats. During laparotomy, two electrodes were implanted into stomach high-frequency low-energy (14 Hz, 5 mA) was applied....
Abstract: The present study investigated the effects of a striatal lesion induced by kainic acid on modulation dopamine (DA) release μ‐ and δ‐opioid peptides. [ d ‐Pen 2 , 5 ]‐enkephalin (DPDPE) ‐Ala ,N‐Me‐Phe 4 ,Gly ‐ol]‐enkephalin (DAGO), two highly selective δ‐ μ‐opioid agonists, respectively, were studied microdialysis in anesthetized rats. In control animals both opioid peptides, administered locally, significantly increased extracellular DA levels. DPDPE also observed whose striatum...
Magnesium sulfate (MgSO4) administration to mothers at risk of preterm delivery is proposed as a neuroprotective strategy against neurological alterations such cerebral palsy in newborns. However, long-term beneficial or adverse effects MgSO4 and sex-specific sensitivity remain be investigated. We conducted behavioral neurochemical studies males females, from the perinatal period adolescence mouse model neonatal lesion. The lesion was produced 5-day-old (P5) pups by ibotenate intracortical...
Intracerebral-intraventricular hemorrhages (ICH/IVH) in very preterm neonates are responsible for high mortality and subsequent disabilities. In humans, tissue plasminogen activator (t-PA) initiates fibrinolysis activates endoluminal-endothelial receptors; dysfunction of the t-PA inhibitor (PAI-1) results recurrent hemorrhages. We used PAI-1 knockout mice to examine role age-dependent intracranial as a possible model ICH/IVH. Intracortical injection 2 μL phosphate-buffered saline produced...
A role of the gut microbiota in psychiatric disorders is supported by a growing body literature. The effects probiotic mixture four bacterial strains were studied two models anxiety and depression, naturally stress-sensitive Fischer rats Long Evans subjected to maternal deprivation. Rats chronically received either (1.109 CFU/day) or vehicle. Anxiety- depressive-like behaviors evaluated several tests. Brain monoamine levels RNA expression tight junction proteins (Tjp) inflammatory markers...
Abstract We have previously shown that striatal dopamine release induced locally by a δ‐opioid receptor agonist was totally inhibited glutamate N ‐methyl‐ d ‐aspartate antagonist, indicating the involvement of glutamatergic receptors in this effect. The aim present study to specify mechanism. Firstly, we investigated effect [D‐Pen 2 ,D‐Pen 5 ]‐enkephalin (DPDPE) on rats intrastriatal microdialysis. infusion DPDPE (10 µ m ) enhanced content dialysate approximately 34%, an which did not appear...