A5036619125- Parkinson's Disease Mechanisms and Treatments
- Autism Spectrum Disorder Research
- Gut microbiota and health
- Child Nutrition and Feeding Issues
- Dysphagia Assessment and Management
- Neurological diseases and metabolism
- Biochemical Analysis and Sensing Techniques
- Diet and metabolism studies
- Nerve injury and regeneration
- Machine Learning in Bioinformatics
- Neuroinflammation and Neurodegeneration Mechanisms
- Asthma and respiratory diseases
- Adipose Tissue and Metabolism
- Gastrointestinal motility and disorders
- Clostridium difficile and Clostridium perfringens research
- Tryptophan and brain disorders
- Gene expression and cancer classification
- Regulation of Appetite and Obesity
- Pediatric health and respiratory diseases
- Bioinformatics and Genomic Networks
- Ginkgo biloba and Cashew Applications
- Infant Health and Development
- Dietary Effects on Health
- Computational Drug Discovery Methods
- Helicobacter pylori-related gastroenterology studies
Utrecht University
2017-2025
Pharmo Institute
2023
Universidad Autónoma de Madrid
2012-2020
Centro de Biología Molecular Severo Ochoa
2020
Cancer Genomics Centre
2018
Consejo Superior de Investigaciones Científicas
2012
Objective Recent evidence suggesting an important role of gut-derived inflammation in brain disorders has opened up new directions to explore the possible gut-brain axis neurodegenerative diseases. Given prominence dysbiosis and colonic dysfunction patients with Parkinson’s disease (PD), we propose that toll-like receptor 4 (TLR4)-mediated intestinal could contribute central PD-related neurodegeneration. Design To test this hypothesis performed studies both human tissue a murine model PD....
Abstract Autism spectrum disorder (ASD) is a highly complex neurodevelopmental characterized by deficits in sociability and repetitive behaviour, however there great heterogeneity within other comorbidities that accompany ASD. Recently, gut microbiome has been pointed out as plausible contributing factor for ASD development individuals diagnosed with often suffer from intestinal problems show differentiated microbial composition. Nevertheless, studies rarely agree on the specific bacterial...
Recent investigations have focused on the potential role of gastrointestinal (GI) abnormalities in pathogenesis Parkinson's disease (PD). The 'dual-hit' hypothesis PD speculates that a putative pathogen enters brain via two routes: olfactory system and GI system. Here, we investigated (1) whether local exposures neurotoxin rotenone gut or mice could induce PD-like neurological phenotypes as well characteristic neuropathology accordance with this 'dual-hit hypothesis' (2) effects diet...
The mechanism of neurodegeneration in Parkinson’s disease (PD) remains unknown but it has been hypothesised that the intestinal tract could be an initiating and contributing factor to neurodegenerative processes. In PD patients as well animal models for PD, alpha-synuclein-positive enteric neurons colon evidence colonic inflammation have demonstrated. Moreover, several studies reported pro-inflammatory bacterial dysbiosis patients. Here, we report first time significant changes composition...
Parkinson's disease (PD) is characterized by the progressive degeneration of dopaminergic nigrostriatal neurons, with reductions in function and amount synapses. Therefore, synapse loss membrane-related pathology provide relevant targets for interventions PD. We previously showed beneficial preventive effects a dietary intervention containing uridine DHA, two precursors membrane synthesis, intrastriatal rotenone model Here, we examined therapeutic potential same on motor, cognitive,...
Autism spectrum disorder (ASD) is a cluster of neurodevelopmental disorders characterized by deficits in communication and behavior. Increasing evidence suggests that the microbiota-gut-brain axis likely related immune imbalance may play role development this disorder. Gastrointestinal gut microbiota dysfunction have been linked to or severity autistic Therefore, treatments focus on specific diets improve gastrointestinal function aberrant behavior individuals with ASD. In study, we...
Several factors are linked to the pathophysiology of autism spectrum disorders (ASD); however, molecular mechanisms condition remain unknown. As intestinal problems and gut microbiota dysbiosis associated with ASD development severity, recent studies have focused on elucidating microbiota-gut-brain axis' involvement. This study aims explore through which might influence ASD. Briefly, we depleted conventional male BALB/cAnNCrl (Balb/c) C57BL/6J (BL/6) mice prior human fecal transplantation...
Autism Spectrum Disorder (ASD) affects approximately 1 child in 54, with a 35-fold increase since 1960. Selected studies suggest that part of the recent prevalence is likely attributable to an improved awareness and recognition, changes clinical practice or service availability. However, this not sufficient explain epidemiological phenomenon. Research points possible link between ASD intestinal microbiota because many children display gastro-intestinal problems. Current large-scale datasets...
Parkinson’s disease patients suffer from both motor and nonmotor impairments. There is currently no cure for disease, the most commonly used treatment, levodopa, only functions as a temporary relief of symptoms. Inhibition expression L‐tryptophan‐catabolizing enzyme tryptophan 2,3‐dioxygenase (TDO) has been shown to inhibit aging‐related α‐synuclein toxicity in Caenorhabditis elegans . To evaluate TDO inhibition potential therapeutic strategy brain‐penetrable, small molecule inhibitor was...
Increasing evidence suggests that the gut–brain axis plays a crucial role in Parkinson's disease (PD). The abnormal accumulation of aggregated alpha-synuclein (aSyn) brain is key pathological feature PD. Intracerebral 6-hydroxydopamine (6-OHDA) widely used dopaminergic lesion model It exerts no aSyn pathology brain, but changes gut have not been assessed. Here, 6-OHDA was administered unilaterally either to rat medial forebrain bundle (MFB) or striatum. Increased levels glial fibrillary...
Abstract Aging in mammals is characterized by failure of the homeostatic mechanisms that regulate energy balance. Several have been proposed such as presence a low-grade chronic inflammation different tissues, well leptin and insulin resistance, but primary alteration not fully elucidated. The gut microbiota has recently emerged key player variety metabolic neurological disorders. A main concept this context gut–brain axis refers to alterations mediate effects central nervous system,...
Though Parkinson's disease (PD) clinical picture is generally dominated by motor impairment, non-motor symptoms, such as cognitive decline and gastrointestinal dysfunctions, may develop before symptoms have major effects on quality of life. Levodopa the most commonly used treatment but has serious side-effects with prolonged use does not stop degenerative process. Moreover, dysfunctions interfere absorption levodopa modify its effectiveness. Since patients are treatment, there a need for...
Parkinson's disease (PD) is a complex neurodegenerative which often associated with gastrointestinal (GI) dysfunction. The GI tract home to wide range of microorganisms, among bacteria, that can influence the host through various mechanisms. Products produced by these bacteria act in gut but also exert effects brain via what now well established be microbiota-gut-brain axis. In those PD gut-bacteria composition found different non-PD individuals. addition compositional changes, metabolic...
Abstract Background Not being well controlled by therapy with inhaled corticosteroids and long‐acting β2 agonist bronchodilators is a major concern for severe‐asthma patients. The current treatment option these patients the use of biologicals such as anti‐IgE treatment, omalizumab, an add‐on therapy. Despite accepted do not always benefit from it. Therefore, there need to identify reliable biomarkers predictors omalizumab response. Methods Two novel computational algorithms, machine‐learning...
The bacterial metabolite 4-methylphenol (para-cresol or p-cresol) and its derivative p-cresyl sulfate (pCS) are elevated in the urine feces of children with autism spectrum disorder (ASD). It has been shown that p-cresol administration induces social behavior deficits repetitive mice. However, mechanisms p-cresol, specifically pCS can reach brain, ASD remain to be investigated. inhibit LPS-stimulated inflammatory response. A Disintegrin And Metalloprotease 10 (ADAM10) 17 (ADAM17) thought...