A5029034592- Atherosclerosis and Cardiovascular Diseases
- Cholesterol and Lipid Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Lipoproteins and Cardiovascular Health
- Cancer, Lipids, and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Antioxidant Activity and Oxidative Stress
- Fatty Acid Research and Health
- Liver Disease Diagnosis and Treatment
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Metabolomics and Mass Spectrometry Studies
- Retinoids in leukemia and cellular processes
- Lipid metabolism and disorders
- Diet and metabolism studies
- Aquaculture Nutrition and Growth
- Cardiovascular Disease and Adiposity
- Cerebrovascular and Carotid Artery Diseases
- Lipid metabolism and biosynthesis
- Protein Hydrolysis and Bioactive Peptides
- CRISPR and Genetic Engineering
- Receptor Mechanisms and Signaling
- Congenital heart defects research
- Eicosanoids and Hypertension Pharmacology
- Nitric Oxide and Endothelin Effects
- Heme Oxygenase-1 and Carbon Monoxide
University of Milan
2016-2025
NIHR Bristol Cardiovascular Biomedical Research Unit
2014
University of Bristol
2014
University of Milano-Bicocca
2006-2013
Fish consumption is considered health beneficial as it decreases cardiovascular disease (CVD)-risk through effects on plasma lipids and inflammation. We investigated a salmon protein hydrolysate (SPH) that hypothesized to influence lipid metabolism have anti-atherosclerotic anti-inflammatory properties. 24 female apolipoprotein (apo) E(-/-) mice were divided into two groups fed high-fat diet with or without 5% (w/w) SPH for 12 weeks. The atherosclerotic plaque area in aortic sinus arch,...
Scope Antarctic krill is a great source of n‐3 fatty acids and high‐quality proteins. Aim the study was to evaluate effect components on plasma lipids atherosclerosis development. Methods results Sixty apoEKO mice were divided into four groups fed Western diet (CONTROL) or Western‐like diets, differing for protein fat content. Specifically, casein in CONTROL partially replaced by proteins (PRO), oil (KRILL OIL), both OIL+PRO). In KRILL OIL+PRO OIL, cholesterol levels significantly lower than...
Abstract The PLPP3 gene encodes for a ubiquitous enzyme that dephosphorylates several lipid substrates. Genome-wide association studies identified as plays role in coronary artery disease susceptibility. aim of the study was to investigate effect Plpp3 deletion on atherosclerosis development mice. Because constitutive mice is lethal, conditional hepatocyte-specific null were generated by crossing floxed with animals expressing Cre recombinase under control albumin promoter. crossed onto...
ABSTRACT Gonadotropin-releasing hormone (GnRH) deficiency (GD) is a disorder characterized by absent or delayed puberty, with largely unknown genetic causes. The purpose of this study was to obtain and exploit gene expression profiles GnRH neurons during development unveil novel biological mechanisms determinants underlying GD. Here, we combined bioinformatic analyses immortalized primary embryonic neuron transcriptomes exome sequencing from GD patients identify candidate genes implicated in...
Many functional foods and dietary supplements have been reported to be beneficial for the management of dyslipidaemia, one major risk factors CVD. Soluble fibres legume proteins are known a safe practical approach cholesterol reduction. The present study aimed at investigating hypocholesterolaemic effect combinations these bioactive vegetable ingredients their possible effects on expression genes regulating homeostasis. A total six groups twelve rats each were fed, 28 d, Nath's...
The aim of this study was to identify, by magnetic resonance imaging (MRI), the ability blood-pool contrast agent B22956/1 detect atherosclerotic plaques developing at brachiocephalic artery apolipoprotein E knockout (apoE-KO) mice and possibly identify vulnerable lesions. After high-fat feeding for 8 or 12 weeks, MRIs arteries were acquired before after administration; then vessels removed analyzed histology. injection caused a rapid increase in plaque signal enhancement muscle values,...
ObjectiveThe aim of the present study was to comprehensively evaluate systemic and local inflammation as well progression vascular in normal mechanically injured vessels a large animal model mild hypercholesterolemia. Our also test effect high-dose statin treatment on these processes. MethodsPigs were kept for 120 days standard diet (SD, n=7), high-cholesterol (HCD, n=7) or with Atorvastatin starting after 50 (STATIN, n=7). Left carotid artery balloon injury conducted all groups 60...
Tetradecylthioacetic acid (TTA) is a hypolipidemic antioxidant with immunomodulating properties involving activation of peroxisome proliferator-activated receptors (PPARs) and proliferation mitochondria. This study aimed to penetrate the effect TTA on development atherosclerotic lesions in apolipoprotein (apo)-E-/- mice fed high-fat diet containing 0.3% for 12 weeks. These displayed significantly less vs control. Plasma cholesterol was increased by administration triacylglycerol (TAG) levels...
Background and Purpose Fenretinide, a synthetic retinoid derivative first investigated for cancer prevention treatment, has been shown to ameliorate glucose tolerance, improve plasma lipid profile reduce body fat mass. These effects, together with its ability inhibit ceramide synthesis, suggest that fenretinide may have an anti‐atherosclerotic action. Experimental Approach To this aim, nine‐week‐old apoE‐knockout (EKO) female mice were fed twelve weeks Western diet, without (control) or...
Objective: HDL (high-density lipoprotein) particles are known to possess several antiatherogenic properties that include the removal of excess cholesterol from peripheral tissues, maintenance endothelial integrity, antioxidant, and anti-inflammatory activities. ApoA-I overexpression in apoE-deficient (EKO) mice has been shown increase levels strongly reduce atherosclerosis development. The aim study was investigate gene expression patterns associated with development aorta EKO how plasma...
Besides a significant reduction of low-density lipoprotein (LDL) cholesterol, statins moderately increase high-density (HDL) levels. In vitro studies have indicated that this effect may be the result an increased expression apolipoprotein (apo)A-I, main protein component HDL. The aim present study was to investigate in vivo rosuvastatin on apoA-I and secretion transgenic mouse model for human apoA-I.Human mice were treated 28 days with 5, 10 or 20 mg·kg(-1) ·day(-1) rosuvastatin, most...
Increased Ankyrin Repeat Domain 1 (ANKRD1) levels linked to gain of function mutations have been associated total anomalous pulmonary venous return and adult cardiomyopathy occurrence in humans. The link between increased ANKRD1 level cardiac structural functional disease is not understood. To get insight into this problem, we generated a mouse model by overexpressing the myocardium.Ankrd1 expressed non-homogeneously embryonic myocardium, with dynamic nucleo-sarcomeric localization...