A5074748865- Insect and Arachnid Ecology and Behavior
- Neurobiology and Insect Physiology Research
- Animal Behavior and Reproduction
- MicroRNA in disease regulation
- Photoreceptor and optogenetics research
- Neuroscience and Neural Engineering
- Extracellular vesicles in disease
- Insect symbiosis and bacterial influences
- Insect Resistance and Genetics
- Plant Molecular Biology Research
- Insect Utilization and Effects
- Circadian rhythm and melatonin
- RNA modifications and cancer
- Transgenic Plants and Applications
- Autism Spectrum Disorder Research
- Cancer-related molecular mechanisms research
- Neural dynamics and brain function
- RNA Research and Splicing
University of Valparaíso
2017-2022
Valparaiso University
2020
Fundación Ciencia and Vida
2020
Abstract Animal circadian clocks consist of central and peripheral pacemakers, which are coordinated to produce daily rhythms in physiology behaviour. Despite its importance for optimal performance health, the mechanism clock coordination is poorly understood. Here we dissect pathway through Drosophila imposes rhythmicity pattern adult emergence. Rhythmicity depends on coupling between brain a prothoracic gland (PG), produces steroid hormone, ecdysone. Time information from transmitted via...
The family of long noncoding mitochondrial RNAs (ncmtRNAs), comprising sense (SncmtRNA), and antisense (ASncmtRNA-1 ASncmtRNA-2) members, are differentially expressed according to cell proliferative status; SncmtRNA is in all proliferating cells, while ASncmtRNAs normal but downregulated tumor cells. ASncmtRNA knockdown with an oligonucleotide induces massive apoptosis lines, without affecting healthy Apoptotic death preceded by proliferation blockage, suggesting that these transcripts...
The gut microbiome has been proposed to influence diverse behavioral traits of animals, although the experimental evidence is limited and often contradictory. Here, we made use tractability Drosophila melanogaster for both analyses studies test how elimination microorganisms affects a number traits. Relative conventional flies (i.e. with unaltered microbiome), microbiologically sterile (axenic) displayed moderate reduction in memory performance olfactory appetitive conditioning courtship...
Abstract During intercellular communication, cells release extracellular vesicles such as exosomes, which contain proteins, ncRNAs and mRNAs that can influence proliferation and/or trigger apoptosis in recipient cells, have been proposed to play an essential role promoting invasion of tumor the preparation metastatic niches. Our group antisense non-coding mitochondrial RNA (ASncmtRNA) a new target for cancer therapy. ASncmtRNA knockdown using oligonucleotide (ASO-1537S) causes massive death...
Eclosion hormone (EH) was originally identified as a brain-derived capable of inducing the behavioral sequences required for molting across insect species. However, its role in this process (called ecdysis) has since been confounded by discrepancies effects genetic and cellular manipulations EH function Drosophila. Although knock-out Eh gene results severe ecdysis-associated deficits accompanied nearly complete larval lethality, ablation only neurons known to express (i.e. Vm neurons) is...
Abstract Autism Spectrum Disorder (ASD) is characterized by impaired social communication, restricted interests, and repetitive stereotyped behaviors. The TRPC6 ( transient receptor potential channel 6 ) represents an ASD candidate gene under oligogenic/multifactorial model based on the initial description cellular characterization of individual with bearing a de novo heterozygous mutation disrupting , together enrichment disruptive variants in cases as compared to controls. Here, we perform...