A5075503783- Adipose Tissue and Metabolism
- Exercise and Physiological Responses
- Muscle Physiology and Disorders
- Neurogenesis and neuroplasticity mechanisms
- Nuclear Receptors and Signaling
- Extracellular vesicles in disease
- Apelin-related biomedical research
- Macrophage Migration Inhibitory Factor
- Nutrition and Health in Aging
- Metabolism, Diabetes, and Cancer
- Muscle metabolism and nutrition
- Behavioral Health and Interventions
- GDF15 and Related Biomarkers
- Obesity, Physical Activity, Diet
- Diet and metabolism studies
- Mitochondrial Function and Pathology
- Functional Brain Connectivity Studies
- Genetics and Physical Performance
- Metabolomics and Mass Spectrometry Studies
- Sirtuins and Resveratrol in Medicine
- Stress Responses and Cortisol
- Autophagy in Disease and Therapy
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Disease and Adiposity
- Galectins and Cancer Biology
Seoul National University
2017-2025
Seoul National University of Education
2018-2025
Institute on Aging
2014-2025
Korea National Sport University
2017-2024
National Institute on Aging
2014-2021
Samsung Medical Center
2020
Sungkyunkwan University
2020
National Institutes of Health
2014-2018
Ulsan National Institute of Science and Technology
2012-2015
Pohang University of Science and Technology
2010-2014
Dysregulation of O-GlcNAc modification catalyzed by transferase (OGT) and O-GlcNAcase (OGA) contributes to the etiology chronic diseases aging, including cancer, cardiovascular disease, type 2 diabetes, Alzheimer's disease. Here we found that natural aging in wild-type mice was marked a decrease OGA OGT protein levels an increase O-GlcNAcylation various tissues. Genetic disruption resulted constitutively elevated embryos led neonatal lethality with developmental delay. Importantly, observed...
Increasing evidence indicates that physical activity and exercise training may delay or prevent the onset of Alzheimer’s disease (AD). However, systemic biomarkers can measure effects on brain function link to relevant metabolic responses are lacking. To begin address this issue, we utilized blood samples 23 asymptomatic late middle-aged adults, with familial genetic risk for AD (mean age 65 years old, 50% female) who underwent 26 weeks supervised treadmill training. Systemic implicated in...
Voluntary exercise is known to have an antidepressant effect. However, the underlying mechanism for this action of remains unclear, and little progress has been made in identifying genes that are directly involved. We identified macrophage migration inhibitory factor (MIF) by analyzing existing mRNA microarray data confirmed augmented expression selected under two experimental conditions: voluntary electroconvulsive seizure. A proinflammatory cytokine, MIF expressed central nervous system...
// Yong Ryoul Yang 1 , Dae Hyun Kim Young-Kyo Seo Dohyun Park 2 Hyun-Jun Jang 1,2 Soo Youn Choi Hwa Lee Gyun Hui Kazuki Nakajima 3 Naoyuki Taniguchi Jung-Min Eun-Jeong Hyo Youl Moon Il Shin Ho 4 Sung Ryu Lucio Cocco 5 and Pann-Ghill Suh School of Life Sciences, Ulsan National Institute Science Technology, Ulsan, Republic Korea Division Molecular Science, Pohang University Pohang, Kyungbuk, Disease Glycomics Team, Systems Glycobiology Research Group, RIKENMax Planck Joint Center, Global...
Anxiety and depression are psychiatric disorders that have a deleterious effect on human mental health. Meanwhile, various forms of exercise been demonstrated to beneficial effects the reduction symptoms anxiety depression. However, disparate each mood remain be elucidated. This research examines different type electroencephalography (EEG) activity. Accordingly, subjects engaged in six weeks aerobic resistance exercises with 3-week washout period between intervention. The Score Hospital...
<title>Abstract</title> <bold>Background</bold> Stroke is a disease influenced by various risk factors, including genetic factors determined single nucleotide polymorphisms (SNPs). Polygenic score (PRS) calculated from multiple SNPs can reflect the varying of stroke. Physical activity critical factor that influences incidence stroke improving other factors. Therefore, we investigated effects physical on reduction across different PRS levels. <bold>Methods</bold> This study utilized...
Introduction Exercise is vital in preventing and treating obesity. Despite its importance, the understanding of how exercise influences childhood obesity at biochemical level limited. In this study, we explore effects a 16-week program (EP) on body composition, physical fitness, blood levels hormones related to Methods Sixteen boys with (n = 16) seventeen without 17) took part an EP comprising sports games aerobic resistance exercises. We examined alterations composition fitness. addition,...
Skeletal muscle undergoes many alterations with aging. However, the impact of aging on muscle's ability to secrete myokines and its subsequent effects body remain largely unexplored. Here, we identify that have potential ameliorate age-related bone decline. Notably, circulating levels cardiotrophin-like cytokine factor 1 (CLCF1) decrease age, while exercise significantly upregulates CLCF1 in both humans rodents. Restoring aged male mice improves their physical performance, glucose tolerance,...
PURPOSE:The purpose of this study was to determine the effects exercise on physical fitness and strength according their frailty level hypertensive female elderly aged over 65.METHODS: Female subjects (>65 year) with hypertension (n=90) were classified (Fr_), divided into control group (Ctrl) (Ex). Hypertensive in groups subjected 8-week combined aerobic (stretching walking) resistance (elastic band weight training) twice per week (50 minutes×2 times×8 weeks). Body composition, functional...
Skeletal muscles are made up of various muscle fiber type including slow and fast-twitch fibers. Because each has its own physiological characteristics, the effects aging exercise vary depending on fiber. We used bioinformatics screening techniques such as differentially expressed gene analysis, ontology analysis set enrichment to try understand genetic differences between types. The experiment expression profiling in this study soleus (SOL, slow-twitch muscle) gastrocnemius (GAS, muscle)....
Neutrophils as first line defender initiate a cascade of healing process immediately after muscle injury. At injury site, neutrophils remove damaged fibers and recruit other immune cells these functions show in mature neutrophils. In the previous study, physical exercise can mediate neutrophils' functional changes such phagocytosis chemotaxis, though there is no research on how exercise-induced contribute regeneration. this present we investigated maturation 4 weeks mouse treadmill assessed...
Physical inactivity can lead to obesity and fat accumulation in various tissues. Critical complications of include type II diabetes nonalcoholic fatty liver disease (NAFLD). Exercise has been reported have ameliorating effects on NAFLD. However, the underlying mechanism is not fully understood. We showed that expression macrophage migration inhibitory factor (MIF) was increased after 4 weeks treadmill exercise. Phosphorylation AMP-activated protein kinase acetyl-CoA carboxylase human...
Although several evidence has suggested the impact of exercise on prevention aging phenotypes, few studies have been conducted mechanism by which alters immune-cell profile, thereby improving metabolism in senile obesity. In this study, we confirmed that 4-week treadmill sufficiently improved metabolic function, including increased lean mass and decreased fat mass, 88-week-old mice. The expression level senescence marker p16 white adipose tissue (WAT) was after 4-weeks exercise. Exercise...