A5101480384- Advanced Chemical Sensor Technologies
- Carcinogens and Genotoxicity Assessment
- Metabolomics and Mass Spectrometry Studies
- Nicotinic Acetylcholine Receptors Study
- Smoking Behavior and Cessation
- Nuclear Physics and Applications
- Analytical Chemistry and Chromatography
- Mass Spectrometry Techniques and Applications
- Air Quality and Health Impacts
- Indoor Air Quality and Microbial Exposure
- Isotope Analysis in Ecology
- Radiation Detection and Scintillator Technologies
- Nuclear physics research studies
- Genomics, phytochemicals, and oxidative stress
- Inhalation and Respiratory Drug Delivery
- Toxic Organic Pollutants Impact
- Synthesis and Biological Evaluation
- Lipid metabolism and biosynthesis
- Nuclear reactor physics and engineering
- Misinformation and Its Impacts
- Nutritional Studies and Diet
- Neuroinflammation and Neurodegeneration Mechanisms
- Analytical chemistry methods development
- Molecular Biology Techniques and Applications
- Neuroscience and Neuropharmacology Research
China Tobacco
2016-2025
Tobacco Research Institute
2010-2025
Hefei Institutes of Physical Science
2015-2025
Chinese Academy of Sciences
2003-2025
Anhui Institute of Optics and Fine Mechanics
2014-2025
University of Science and Technology of China
2024-2025
Beijing Academy of Science and Technology
2023-2025
Jiangnan University
2022-2024
Central South University
2022-2024
Third Xiangya Hospital
2023-2024
Introduction In the response to and prevention control of Novel coronavirus pneumonia, COVID-19 vaccine does not provide lifelong immunity, it is therefore important increase rate booster shots vaccine. field information health science, research has found that frames have an impact in changing individual attitudes behaviors. Objective This study focuses on effects different influencing factors public’s willingness receive under two frameworks. Methods An online questionnaire was conducted...
Obesity and obesity-related metabolic diseases are causally linked to inflammatory activation. Proinflammatory macrophage infiltration NOD-like receptor pyrin domain containing 3 (NLRP3) inflammasome activation contribute chronic inflammation insulin resistance. Alleviating responses is a reliable method restore sensitivity reduce the severity of syndrome. Solanesol, rich in anti-inflammatory foods (potato, tomato, eggplant, chili peppers), has demonstrated properties, but whether it plays...
Abstract Introduction While smoking has been associated with many negative consequences to human health, one possible benefit is that nicotine could improve cognitive functions. Previous studies have suggested may influence brain-derived neurotrophic factor (BDNF) levels. However, the exact effects of on BDNF and cognition, potential neurobiological mechanisms underlying changes induced by nicotine, remains elusive. Methods Two tobacco products were used in population detect plasma BDNF,...
The study of lipid metabolism relies on the characterization lipidome, which is quite complex due to structure variations species. New analytical tools have been developed recently for characterizing fine structures lipids, with C=C location identification as one major improvements. In this study, we studied reprograming by analyzing glycerol phospholipid compositions in breast cancer cell lines structural specification extended level. Inhibition desaturase, stearoyl-CoA desaturase 1,...
A simple and sensitive high performance liquid chromatography-tandem mass spectrometry (HPLC-ESI-MS-MS) method was developed validated for the quantification of creatinine in human urine. The analysis carried out on an Agilent Zorbax Eclipse XDB-C18 column (2.1 × 150 mm, 3.5 μm). mobile phase 0.1% formic acid water acetonitrile (50/50, v/v). Linear calibration curves were obtained concentration range 1-2000.0 ng/mL, with a lower limit 0.99 ng/mL. intra- interday precision (RSD) values below...
A multiresidue gas chromatography-tandem mass spectrometry (GC-MS/MS) method was developed for the analysis of 159 multiclass pesticides in tobacco. modified QuEChERS sample preparation technique, based on acetonitrile extraction and toluene dilution, followed by dispersive solid-phase (d-SPE) cleanup using primary-secondary amine (PSA) octadecyl (C18) sorbents, used treatment. Key performance parameters investigated were linearity, recovery, relative standard deviation (RSD), limit...
Cardiovascular and respiratory diseases, several cancers resulting from tobacco smoking, are initially characterized by chronic systemic inflammation. Cytokine imbalances can result in inflammation, making it important to understand the pathological mechanisms behind cytokine production. In this study, we collected blood samples 78 healthy male volunteers, including non-smokers (n = 30), current smokers ex-smokers 18), utilized liquid suspension chip technique investigate compare expression...
Nicotine lactate, nicotine tartrate, benzoate, and freebase (FBN) are four forms of salt systems that present in tobacco products. However, few vivo studies have compared their pharmacological (pK) efficacies, which important for understanding roles the addiction abuse In this work, pK above was studied by subcutaneously injecting aqueous solutions rats obtaining blood samples from jugular vein. levels were analyzed LC-MS/MS. The results demonstrated rapid absorption occurred all systems. Of...
Cigarette smoke is a harmful air pollutant and nicotine dependence the essential cause of tobacco epidemic. Since mitochondrial abnormalities are associated with substance addiction, in this work we used DNA (mtDNA) copy number as an indicator function to investigate whether addicts also exhibit abnormalities. We found significantly lower mtDNA peripheral blood healthy than non-smokers, indicating that long-term exposure through smoking has detrimental effects on mitochondria. examined...
Abstract Evaluating the source of nicotine in e‐liquid is a problem. Tobacco‐derived contains predominantly (S)‐(−)‐nicotine, whereas tobacco‐free products may not. Thus, we developed new normal phase high‐performance liquid chromatography method to determinate enantiomeric composition 10 kinds flue‐cured tobacco, 3 burley, 1 kind cigar 2 oriental 5 Virginia cigarette, blend e‐liquid, and 4 smokeless tobacco. The amount (R)‐(+)‐nicotine ranged from ~0.02% ~0.76% total nicotine. An sample had...
The Monoamine Oxidase-A ( MAOA ) EcoRV polymorphism (rs1137070) is a unique synonymous mutation (c.1409 T > C) within the gene, which plays crucial role in Maoa gene expression and function. This study aimed to explore relationship between mouse rs1137070 genotype differences expression. Mice carrying CC of exhibited significantly lower level, with an odds ratio 2.44 compared carriers. Moreover, wild-type TT demonstrated elevated mRNA longer half-life. We also delved into significant...
Abstract The discovery of new laryngeal cancer‐related metabolite biomarkers could help to facilitate early diagnosis. A serum metabolomics study from cancer patients and healthy individuals was conducted using liquid chromatography coupled with quadrupole time‐of‐flight mass spectrometry. Univariate multivariate statistics were used discriminate individuals. 1‐Palmitoyl‐sn‐glycero‐3‐phosphocholine (LysoPC 16:0), 1‐ o ‐hexadecyl‐2‐acetyl‐sn‐glycero‐3‐phosphocholine (PAF)...
Aldehydes are common air pollutants with carcinogenicity. Genotoxicity of single aldehyde has been studied well, but the combined genotoxicity is rarely known. Here, we evaluated formaldehyde and acrolein on BEAS-2B cells in terms DNA strands breakage, chromosome damage gene mutation below subcytotoxic concentrations covering smoking-related concentrations. Meanwhile, molecular mechanism was investigated further based oxidative stress, DNA-protein crosslinks (DPCs), cell cycle damage-repair...