The compounds of Radix Paeoniae Rubra (RPR) were isolated and identified by bioassay-guided method, antithrombotic effects mechanism investigated the acute blood stasis rat model. RPR extract was evaluated APTT, TT, PT, FIB assays in vitro. Results indicated that exhibited anticoagulant activity. In order to find active compounds, six identified, four paeoniflorin (Pae), pentagalloylglucose (Pen), albiflorin (Ali), protocatechuic acid (Pro), activity Therefore, antithrombosis vivo measuring...

We design and synthesize four naphthalimide (NI)-based organic cathode interlayer materials (CIMs) end-capped with electron-withdrawing heteroaromatic rings, namely NTDC, NTR, NTRIC NTTC. Compared NTN (bis(N-dimethylaminopropyl)-4-thiophene-1,8-naphthalimide), a reported CIM,...

Schisandrin B (Sch B) is an active component in Schisandra chinensis exerting anti-cancer effect, but the mechanism obscure. This study was designed to explore of Sch against colorectal cancer (CRC). Apparent experiments including cell proliferation, transwell, colony formation, etc. were carried out assess effect CRC lines, and RNA-seq performed prior bioinformatics analysis key transcriptome alterations, furthermore, untargeted metabolomics profile metabolic alterations after treatment...

Antioxidant and α-glucosidase inhibitiory active compounds of Cercis chinensis flowers were investigated with bio-assay guiding method. Ethyl acetate fraction (CLEa) n-butanol (CLBu) exhibited antioxidant activity in vitro, the corresponding fractions, EaFr.3, EaFr.5 BuFr.1, higher than those other fractions. Eight compounds, ethyl gallate (1), stearic acid (2), docosanoic (3), 5α-stigmast-9(11)-en-3β-ol (4), kaempferol-3-O-α-rhamnopyranoside (5), vanillic (6), fisetin (7), β-sitosterol (8),...

Hericium erinaceus is a precious edible and medicinal fungus with high nutritional value. It has many functions, such as enhancing immunity, antitumor antioxidation, antihyperglycemic, antihyperlipidemic, protecting gastric mucosa. However, there are few researches about the H. compounds. In this paper, ultraperformance liquid chromatography tandem high-resolution mass spectrometry (UPLC-Q-exactive-MS/MS) was used to isolate identify compounds in erinaceus. 102 were identified by comparing...

The combined prescriptions of nirmatrelvir/ritonavir and other drugs are limited due to potential drug-drug interactions, so therapeutic drug monitoring (TDM) becomes particularly important. In this study, a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was established for determination the in plasma patients with COVID-19, providing technical theoretical support TDM. Plasma samples were processed by protein precipitation using acetonitrile, analytes separated on an...

Objective: This study aims to explore the mechanism underlying induction of phlebitis by aescinate and create an early-warning model based on metabolomics. Methods: Patients with cerebral infarction enrolled had been treated aescinate. Plasma samples were collected either before administration aescinate, upon occurrence phlebitis, or at end treatment. Non-targeted metabolomics targeted amino acid carried out analyze metabolic profiles quantify metabolites. Results: Untargeted revealed six...

Lentinus edodes and Auricularia auricula are the first second largest edible fungi in China with high nutritional medicinal values. Research about phytochemicals of L. A. mainly focuses on polysaccharides, other not fully studied. Phytochemicals were investigated by ultra-high performance liquid chromatography tandem hybrid quadrupole-orbitrap mass spectrometry (UPLC-Q-Exactive-Orbitrap MS). Twenty-three compounds identified edodes, including amino acids analogs, flavonoids, nucleosides...

Abstract: We recently reported that electret, which was prepared by a corona charging system with polypropylene film, could enhance the transdermal delivery of several drugs low molecular weight. The aim this study to investigate whether electret protein N -trimethyl chitosan nanoparticles (TMC NPs) an ionic gelation method. A series experiments were performed, including in vitro skin permeation assays and anti-inflammatory effects, evaluate TMC NPs presence electret. results showed...

The leaves and bark of Syringa oblata Lindl are used as folk medicine which has heat-clearing, detoxifying, dampness-removing jaundice-relieving effects. There many studies about S. because its abundant resource, however, less reports the components flowers. previous on oblate flowers were mainly focused volatile traditional pharmacological activity. Thus, this study aimed to investigate nonvolatile chemical constituents coagulation activity isolated with various column chromatographies...

Ligustri lucidi Fructus is a traditional Chinese medicine and possesses various bioactivities, including hypoglycemic effect. Ligustrum lucidum Ait flowers are poorly investigated. Thus, we hypothesized that L. also could have Chemical composition glucose uptake effect of on 3T3-L1 adipocytes were In this study, the components investigated by chromatographic spectroscopic methods effects induction adipocytes. Seven compounds isolated identified from flowers, ursolic acid (1),...

The combined prescriptions of nirmatrelvir/ritonavir (Paxlovid) and other drugs are limited due to potential interaction, so therapeutic drug monitoring (TDM) becomes particularly important. In this study, a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was established for determination the in plasma patients with COVID-19, providing technical theoretical support TDM. Plasma samples were processed by protein precipitation using acetonitrile analytes separated on an Agilent...

Symbol sharing that is facilitated by current technologies hampered the incompatibility of map-symbol models with existing heterogeneous resources. After a comparative analysis terminology and symbol construction strategies in models, an improved model presented to facilitate sharing. The combines description methods enable broad compatibility mapping/geographic information systems (GISs). Extensional have also been proposed support various symbols different levels graphic complexity....

Flammulina velutipes is the fourth largest edible fungus in China with high nutritional value. In this paper, ultrahigh-performance liquid chromatography tandem hybrid quadrupole-Orbitrap mass spectrometry (UPLC-Q-Exactive-Orbitrap MS) was used to identify secondary metabolites of F. velutipes. The were identified by comparing retention time, accurate molecular weight, and MS2 data standard databases mzVault mzCloud (compound: 17,000+) BGI high-resolution plant metabolome database (plant...

The hepatoprotective effects of kiwifruit seed oil (KSO) were evaluated on acute liver injury (ALI) induced by carbon tetrachloride (CCl 4 ) in vivo .

Electret offers enhancing effect in transdermal drug delivery for altering of the arrangement lipid molecules stratum corneum, forming many transient permeable apertures and delivery. In this paper, meloxicam patch formulations were developed to make comparative study between electret chemical enhancers. Patches made into control, electret, enhancer with ones, according preparation procedure. The combined was designed probe incorporation release from found increase order blank, enhancer,...

Polypropylene (PP) electrets with surface potential of −500V, −1000V and −2000V were prepared by constant voltage corona charging. The applied to excised rat skin for 2 hours respectively then the samples analyzed differential scanning calorimetry (DSC) technique study alteration lipid organization skin. There three peaks at 63°C, 82.7°C 115.1°C in DSC spectra untreated, which have been assigned essentially lipid, lipid-protein protein alterations. For −500V electret treated-skin sample,...