A5051817428- Fungal Biology and Applications
- Polysaccharides and Plant Cell Walls
- Pharmacological Effects of Natural Compounds
- Natural product bioactivities and synthesis
- Gut microbiota and health
- Chromatography in Natural Products
- Polysaccharides Composition and Applications
- Nigella sativa pharmacological applications
- Phytochemistry and Biological Activities
- Bioactive Compounds and Antitumor Agents
- Phytochemistry and Bioactive Compounds
- Essential Oils and Antimicrobial Activity
- Plant-based Medicinal Research
- Seaweed-derived Bioactive Compounds
- Phytochemicals and Antioxidant Activities
- Herbal Medicine Research Studies
- Medicinal Plants and Bioactive Compounds
- Ginseng Biological Effects and Applications
- Computational Drug Discovery Methods
- Postharvest Quality and Shelf Life Management
- Bioactive natural compounds
- Microbial Metabolites in Food Biotechnology
- Traditional Chinese Medicine Analysis
- Phytochemical Studies and Bioactivities
- Natural Antidiabetic Agents Studies
Henan University
2015-2025
Kaifeng University
2018-2024
First Affiliated Hospital of Henan University
2024
City University of Hong Kong, Shenzhen Research Institute
2023
China Agricultural University
2015
Antimicrobial resistance was one of serious worldwide problems confused many researchers. To solve this problem, we explored the antibacterial effect chelerythrine, a natural compound from traditional Chinese medicine and studied its action. The contents chelerythrine different fractions Toddalia asiatica (Linn) Lam (T. asiatica) were determined. anti-bacterial activities tested by disc diffusion method (K-B method). Scanning electron microscopy (SEM), alkaline phosphatase (AKP), bacterial...
Proteomics and intestinal flora were used to determine the mechanism of immune modulatory effects Flammulina velutipes polysaccharide on immunosuppressed mice. The results showed that compared with model group, F. could increase thymus spleen indices improve tissue structure in mice; IL-2 IL-4 contents significantly increased IL-6 TNF-α decreased; serum acid phosphatase (ACP), lactate dehydrogenase (LDH) total antioxidant capacity (T-AOC) activities (P < 0.05); liver, superoxide dismutase...
Pleurotus spp. was one of the most precious and common edible fungi, polysaccharides were main active component. The structural, biological activities structure-activity relationship (SAR) from systematically reviewed. On basis structure activity, relationships also analyzed discussed to look forward its future research direction application prospect. In past 5 years, about 30 kinds isolated spp., their preliminary structures studied, but fine seldomly reported. showed immunomodulatory,...
Two immunomodulatory polysaccharides (Vp2a-II and Vp3) were isolated identified from Apocynum venetum L. flowers, their innate immune-stimulating functions working mechanisms evaluated in RAW264.7 cells. Both the level of released nitric oxide (NO) expression inducible synthase (iNOS) mRNA significantly enhanced macrophages cells treated by Vp2a-II Vp3. (100–800 µg/mL) Vp3 (400 could increase phagocytic activity secretion TNF-α IL-6 a concentration-dependent manner through affecting...
The immunomodulatory effects of Malus halliana flower polysaccharide (MHFP) were investigated in this paper. model immunosuppressive mice was established by cyclophosphamide, which treated with different dosages MHFP (600, 400, and 200 mg/kg·d -1 ). results showed that significantly increased the index spleen thymus improved atrophy immune organs. enhanced ability carbon clearance phagocytosis mononuclear phagocytes mice. Meanwhile, promoted proliferation splenic lymphocytes. could enhance...
This study was designed to elucidate the immunoregulation of Ganoderma lucidum. HPLC fingerprint and spectrum-effect relationship G. lucidum were established predict active compounds BP neural network model efficacy. Then target identified by high resolution mass spectrometry. The results indicated that there are both enhanced immunity immunosuppressive components in trained with common peak area immune efficacy index as samples, a combined evaluation system established. correlation...
Hyperlipidemia is a kind of lipid metabolism disease, whose pathogenesis complex and diverse, mainly related to abnormal glucose metabolism, as well insulin resistance other characteristics. Because their low toxic side effects along with clear medicinal effects, the food homological resources are widely used in regulation blood lipids recent years. The State Administration for Market Regulation website various databases have been searched use materials functional products, categories...
One new diterpenoid, diaporpenoid A (1), two sesquiterpenoids, diaporpenoids B–C (2,3) and three α-pyrone derivatives, diaporpyrones A–C (4–6) were isolated from an MeOH extract obtained cultures of the mangrove endophytic fungus Diaporthe sp. QYM12. Their structures elucidated by extensive analysis spectroscopic data. The absolute configurations determined electronic circular dichroism (ECD) calculations a comparison specific rotation. Compound 1 had unusual 5/10/5-fused tricyclic ring...
Poria is a common Traditional Chinese Medicine in clinic. In recent years, the chemical and pharmacological studies of have made great progress, triterpenes polysaccharides been isolated, various types compounds containing lipids, octanoic acids, fatty trace elements found. this paper, we reviewed literature, summarized main compound types, detail their effects antitumor, immunomodulatory, on kidney, hepatoprotective activity, blood sugar, antioxidant effects, anti-inflammatory gut,...
This is the first report on a polysaccharide (RCJ2-Ib) isolated from Rosa Chinensis Flos. RCJ2-Ib was obtained through extraction with water, precipitation ethanol, separation DEAE-52 column and purification DEAE-Sepharose Fast Flow Sephadex G100 column. GC, FT-IR NMR analyses revealed that (3.3 kDa) 1,4-linked polymannuronic acid containing substantial β-D-anomers units. The anticoagulant effect of evaluated by using rabbit ear venous blood an acute stasis rat model showed had obvious...