A5015911668- Ubiquitin and proteasome pathways
- RNA Research and Splicing
- Genomics and Chromatin Dynamics
- Plant-Microbe Interactions and Immunity
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Marine Bivalve and Aquaculture Studies
- Fungal Infections and Studies
- Epigenetics and DNA Methylation
- Invertebrate Immune Response Mechanisms
- Cancer, Stress, Anesthesia, and Immune Response
- Studies on Chitinases and Chitosanases
- Neuroscience and Neuropharmacology Research
- Cellular transport and secretion
- Microtubule and mitosis dynamics
- Signaling Pathways in Disease
- Histone Deacetylase Inhibitors Research
- DNA Repair Mechanisms
- Pneumocystis jirovecii pneumonia detection and treatment
- Cancer-related gene regulation
- Cephalopods and Marine Biology
- Legume Nitrogen Fixing Symbiosis
- Anesthesia and Sedative Agents
- Cancer Research and Treatments
- Aquaculture disease management and microbiota
- Probiotics and Fermented Foods
Shanghai Changzheng Hospital
2024
New England Biolabs (China)
2017-2021
Large-scale crotonylome reveals CDYL-regulated crotonylation in diverse functions including RPA-mediated HR DNA repair.
Summary During seed germination, cells embark on extensive post‐transcriptional and post‐translational modifications (PTM), providing a perfect platform to study these events in embryo rebooting from relative quiescenct highly active state. PR‐619, deubiquitylase inhibitor, delayed the rice germination resulted accumulation of ubiquitylated proteins, which indicated protein ubiquitylation is involved this process. Using K‐Ɛ‐GG antibody enrichment method integrated with high‐resolution mass...
Grass carp (Ctenopharyngodon idellus) is an important worldwide commercial freshwater culture species. However, grass reovirus (GCRV) causes serious hemorrhagic disease in fingerlings and yearlings of fishes. To understand the molecular pathogenesis host cells during GCRV infection, intensive proteomic quantification analysis lysine acetylation Ctenopharyngodon idella kidney (CIK) was performed. Using dimethylation labeling-based quantitative proteomics, 832 acetylated proteins with 1391...
Abstract Pluripotent stem cells (PSCs) can be expanded in vitro different culture conditions, resulting a spectrum of cell states with distinct properties. Understanding how PSCs transition from one state to another, ultimately leading lineage-specific differentiation, is important for developmental biology and regenerative medicine. Although there significant information regarding gene expression changes controlling these transitions, less known about post-translational modifications...
Stem-cell differentiation is a complex biological process controlled by series of functional protein clusters and signaling transductions, especially metabolism-related pathways. Although previous studies have quantified the proteome phosphoproteome for stem-cell differentiation, investigation acylation-mediated regulation still absent. In this study, we quantitatively profiled proteome, acetylome, succinylome in pluripotent human embryonic stem cells (hESCs) differentiated hepatocyte-like...
Abstract Propofol and dexmedetomidine are both commonly used anaesthetics. Although they employ two different mechanisms to induce anaesthesia, compounds influence the hippocampus HT22 cell line. cells broadly in neurobiological research. In this study, we assessed effects of propofol on signalling cells. Using SILAC (stable isotope labelling with amino acids culture) technique, IMAC (immobilized metal affinity chromatography) enrichment high-resolution LC-MS/MS (liquid chromatography tandem...
The data presented in this article are related to the publication entitled "Malonylome analysis of rhizobacterium Bacillus amyloliquefaciens FZB42 reveals involvement lysine malonylation polyketide synthesis and plant-bacteria interactions"(doi:10.1016/j.jprot.2016.11.022) (B. Fan, Y. Li, L. Li et al.) [1]. This raw information all malonyllysine sites identified by LC-MS/MS FZB42. Further, functional features conservation malonylated peptide/proteins were analyzed made publicly available...
Abstract Pluripotent stem cells (PSCs) can be expanded in vitro different culture conditions, resulting a spectrum of cell states with distinct properties. Understanding how PSCs transition from one state to another, ultimately leading lineage-specific differentiation, is important for developmental biology and regenerative medicine. Although there significant information regarding gene expression changes controlling these transitions, less known about post-translational modifications...