A5100623727- Metabolomics and Mass Spectrometry Studies
- Traditional Chinese Medicine Analysis
- Phytochemistry and Biological Activities
- Natural product bioactivities and synthesis
- Phytochemistry and Bioactive Compounds
- Renal Transplantation Outcomes and Treatments
- Pharmacological Effects and Toxicity Studies
- Metabolism and Genetic Disorders
- Phytochemical Studies and Bioactivities
- Pharmacological Effects of Natural Compounds
- Piperaceae Chemical and Biological Studies
- Neurological Disorders and Treatments
- Morinda citrifolia extract uses
- Spondyloarthritis Studies and Treatments
- Cancer Treatment and Pharmacology
- Antibiotics Pharmacokinetics and Efficacy
- Pregnancy and Medication Impact
- Ginseng Biological Effects and Applications
- Plant-based Medicinal Research
- Lung Cancer Treatments and Mutations
- Inflammasome and immune disorders
- Cancer therapeutics and mechanisms
- Medicinal Plant Pharmacodynamics Research
- Infectious Encephalopathies and Encephalitis
- Chemotherapy-induced cardiotoxicity and mitigation
Zhejiang Taizhou Hospital
2025
Wenzhou Medical University
2025
Second Military Medical University
2014-2024
Shanghai Changzheng Hospital
2011-2024
Yunnan University of Traditional Chinese Medicine
2021-2024
Naval Medical Research Command
2023
<i>Wuzhi</i> capsule (WZC) is a preparation of an ethanol herbal extract <i>Schisandra sphenanthera</i> (Nan-Wuweizi), with its main active ingredients that include schisandrin, schizandrol B, schisantherin A, schisanhenol, and deoxyschizandrin. WZC tacrolimus are often coadministered for the treatment drug-induced hepatitis in organ transplant recipients China. Recently, it was reported could significantly increase blood concentration tacrolimus. The purpose this study to investigate...
Shengxian Decotion (SXT), a well-known Traditional Chinese Medicine (TCM) formula composed of Astragali Radix, Bupleuri Cimicifugae Rhizoma, Anemarrhenae Rhizoma and Platycodonis is clinically considered as an effective against cardiovascular diseases. However, the exact substance SXT in treating chronic heart failure (CHF) still remains unclear. In current study, we investigated benefit doxorubicin (DOX)-induced CHF rats established UHPLC-MS/MS method to simultaneously determine 18 key...
Isatis indigotica (Ii) is a cruciferous herb that widely distributed in China, and its roots leaves have been used two renowned antipyretic detoxicate crude drugs Chinese Pharmacopoeia, Radix (R) Folium (F) Isatidis. However, the pharmacodynamic material basis underlying mechanisms of herbal efficacy remained to be elucidated.Ultra-performance liquid chromatography-quadrupole-time-of-flight mass spectrometry (UPLC-Q-TOF-MS) was adopted for chemical profiling R F The active ingredients were...
1. Antithrombotic agents are effective in the treatment of ischaemic stroke. Timosaponin B-II (TB-II) is a major active component Anemarrhena asphodeloides Bunge (Liliaceae; rhizome) that has protective effects against cerebral damage. The present study examined antiplatelet and antithrombotic actions TB-II. 2. In vitro experiments, TB-II (20, 40 80 mg/mL) potently dose-dependently inhibited ADP-induced platelet aggregation. Furthermore, 1, 3 6 mg/kg prolonged activated partial...
The combined prescriptions of nirmatrelvir/ritonavir and other drugs are limited due to potential drug-drug interactions, so therapeutic drug monitoring (TDM) becomes particularly important. In this study, a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was established for determination the in plasma patients with COVID-19, providing technical theoretical support TDM. Plasma samples were processed by protein precipitation using acetonitrile, analytes separated on an...
Calcineurin inhibitor nephrotoxicity, especially for the widely used tacrolimus, has become a major concern in post-transplant immunosuppression. Multiparametric amino acid metabolomics is useful biomarker identification of tacrolimus which specific quantitative methods are highlighted as premise. This article presents targeted metabolomic assay to quantify 33 acids and biogenic amines human urine by high-performance liquid chromatography coupled with tandem mass spectrometry....
Objective: This study aims to explore the mechanism underlying induction of phlebitis by aescinate and create an early-warning model based on metabolomics. Methods: Patients with cerebral infarction enrolled had been treated aescinate. Plasma samples were collected either before administration aescinate, upon occurrence phlebitis, or at end treatment. Non-targeted metabolomics targeted amino acid carried out analyze metabolic profiles quantify metabolites. Results: Untargeted revealed six...
Shengxian Decoction (SXT), a classic Traditional Chinese Medicine (TCM) prescription, consists of five TCMs: Astragali Radix, Anemarrhenae Rhizoma, Bupleuri Platycodonis Radix (PG), and Cimicifugae Rhizoma. SXT has been demonstrated to show good therapeutic effects on the cardiovascular system. A metabolomic approach was applied study its mechanisms synergistic properties PG. UPLC-Q-TOF/MS based profiling adopted assess intervention SXT, SXT-PG (SXT lacking PG) PG, chronic heart failure...
Background: A rapid and sensitive analytical method using liquid chromatography coupled with electrospray ionization tandem mass spectrometry (LC-MS/MS) was developed for the determination of paclitaxel, docetaxel, vinblastine, vinorelbine in human plasma. Methods: simple liquid–liquid extraction procedure applied only 100-μL Chromatographic separation these anticancer drugs achieved an isocratic mobile phase consisting acetonitrile/aqueous buffer (10 mmol/L ammonium acetate 0.1% formic acid...
Few literatures have evaluated the exact role of metabolomics in identification process potential biomarkers for acute kidney injury among patients receiving renal transplantation. On top this, success biomarker translation seems to lie robust quantitative method. As such, a single-center retrospective observational study was conducted enrolling 42 underwent transplantation with/without injury, as well 24 healthy volunteers, Shanghai Changzheng Hospital. Plasma amino acid metabolic patterns...
Current treatment options for patients with stage 5 chronic kidney disease before dialysis (predialysis CKD-5) are determined by individual circumstances, economic factors, and the doctor's advice. This study aimed to explore plasma metabolic traits of predialysis CKD-5 compared maintenance hemodialysis (HD) peritoneal (PD) patients, learn more about impact process on blood environment.Our enrolled 31 HD 30 PD patients. Metabolite profiling was performed using a targeted metabolomics...
The combined prescriptions of nirmatrelvir/ritonavir (Paxlovid) and other drugs are limited due to potential interaction, so therapeutic drug monitoring (TDM) becomes particularly important. In this study, a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was established for determination the in plasma patients with COVID-19, providing technical theoretical support TDM. Plasma samples were processed by protein precipitation using acetonitrile analytes separated on an Agilent...