A5067271160- Phytochemical Studies and Bioactivities
- Natural product bioactivities and synthesis
- Helicobacter pylori-related gastroenterology studies
- Sesquiterpenes and Asteraceae Studies
- Cancer-related molecular mechanisms research
- Traditional Chinese Medicine Analysis
- Phytochemistry and Biological Activities
- Magnolia and Illicium research
- Digestive system and related health
- RNA modifications and cancer
- Cancer Research and Treatments
- Medicinal Plant Pharmacodynamics Research
- Gastrointestinal disorders and treatments
- Phytochemical compounds biological activities
- Phytochemistry and Bioactive Compounds
- Ferroptosis and cancer prognosis
- Cancer-related gene regulation
- Phagocytosis and Immune Regulation
- Ubiquitin and proteasome pathways
- Cynara cardunculus studies
- Barrier Structure and Function Studies
- Trace Elements in Health
- Morinda citrifolia extract uses
- Plant chemical constituents analysis
- Cancer Immunotherapy and Biomarkers
Yuxian People's Hospital
2025
Second Military Medical University
2010-2024
Second Affiliated Hospital of Zhengzhou University
2024
First Affiliated Hospital of Zhengzhou University
2018-2021
National Clinical Research Center for Digestive Diseases
2019-2020
Xijing Hospital
2019-2020
Air Force Medical University
2019
Shanghai Changzheng Hospital
2009-2015
Abstract Objective This study investigated the effect and mechanism of POU6F1 lncRNA-CASC2 on ferroptosis gastric cancer (GC) cells. Methods GC cells treated with erastin RSL3 were detected for ferroptosis, reactive oxygen species (ROS) level, cell viability. The expression levels POU6F1, lncRNA-CASC2, SOCS2, ferroptosis-related molecules (GPX4 SLC7A11) also measured. regulations among FMR1, SLC7A11 determined. Subcutaneous tumor models established, in which expressions Ki-67, GPX4 by...
1. Antithrombotic agents are effective in the treatment of ischaemic stroke. Timosaponin B-II (TB-II) is a major active component Anemarrhena asphodeloides Bunge (Liliaceae; rhizome) that has protective effects against cerebral damage. The present study examined antiplatelet and antithrombotic actions TB-II. 2. In vitro experiments, TB-II (20, 40 80 mg/mL) potently dose-dependently inhibited ADP-induced platelet aggregation. Furthermore, 1, 3 6 mg/kg prolonged activated partial...
Intestinal metaplasia (IM) is a premalignant lesion associated with gastric cancer. Both animal and clinical studies have revealed that bile acid reflux subsequent chronic inflammation are key causal factors of IM. Previous indicated SOX2, the transcription factor in differentiation, was downregulated during IM development while CDX2, pivotal intestine-specific upregulated significantly. However, it remains unclear whether downregulation SOX2 promotes emergence or merely concomitant...
Gastric intestinal metaplasia (GIM) is the essential pre‐malignancy of gastric cancer. Chronic inflammation and bile acid reflux are major contributing factors. As an development transcription factor, caudal‐related homeobox 2 (CDX2) key in GIM. Resveratrol has potential chemopreventive anti‐tumour effects. The aim study to probe effect resveratrol acid‐induced We demonstrated that could reduce CDX2 expression a time‐ dose‐dependent manner cell lines. A Cignal Finder 45‐Pathway Reporter...
A new polyacetylene glucoside (3E,5E,11E)-tridecatriene-7,9-diyne-1,2,13-triol-2-O-β-D-glucopyranoside (1), a phenylpropanoid 2'-butoxyethylconiferin (2), and flavonoid glycoside 8,3',4'-trihydroxyflavone-7-O-(6''-O-p-coumaroyl)-β-D-glucopyranoside (3), have been isolated from Bidens frondosa together with fifty-three known compounds 4-56. The structures of these were established by spectroscopic methods. mainly ESIMS, 1D- 2D-NMR data. comparison literature Compounds 1-34, 36, 39, 43, 47,...
Intestinal metaplasia (IM) increases the risk of gastric cancer. Our previous results indicated that bile acids (BAs) reflux promotes IM development through kruppel-like factor 4 (KLF4) and caudal-type homeobox 2 (CDX2) activation. However, underlying mechanisms remain largely elusive. Herein, we verified secondary BAs responsive G-protein-coupled acid receptor 1 (GPBAR1, also known as TGR5) was increased significantly in specimens. Moreover, TGR5 contributed to deoxycholic (DCA)-induced...
Tanreqing injection, a classical Traditional Chinese Medicine formulation, consists of Radix Scutellariae baicalensis, Fel selenarcti, Cornu naemorhedi, Flos lonicerae and Forsythiae fructus, having marked curative effect on the diseases upper respiratory tract. In order to clarify its chemical profile, method based liquid chromatography coupled with time-of-flight mass spectrometry was proposed, 53 compounds were identified formula database 515 known aid accurate measurement for molecular...
Investigation of the ethanol extract whole plant Ainsliaea yunnanensis led to isolation four new dimeric sesquiterpene lactones, ainsliadimer F-I (1-4), together with seven known lactones (5-11) and ten sesquiterpenes (12-21). Their structures were elucidated by spectroscopic methods. The relative stereochemistry F was further confirmed single crystal X-ray diffraction analysis. Compounds 1-21 tested for inhibition nuclear factor kappa B (NF-κB) in 293-NF-κB-luciferase reporter cell line...
Dickkopf-related protein 1 (DKK1) is essential to gastric cancer as an inhibitor of Wnt signaling. Gastric intestinal metaplasia (GIM) important precancerous lesion that can be activated by bile acid reflux and chronic inflammation. However, the exact mechanism DKK1 in acid-induced GIM has not been completely elucidated. We aimed explore epigenetic alterations biological functions development GIM. In present study, was found induce expression markers epithelial cells, whereas downregulated...
<h3>Objective:</h3> Hepatocyte nuclear factor 4α (<i>HNF4A</i>) has been demonstrated to be an oncogene in gastric cancer (GC). However, the roles of different <i>HNF4A</i> isoforms derived from 2 promoters (P1 and P2) underlying mechanisms remain obscure. <h3>Methods:</h3> The expression prognostic values P1- P2-<i>HNF4A</i> were evaluated Cancer Genome Atlas (TCGA) databases GC tissues. Then, functional assays conducted both <i>in vivo</i> vitro</i>. High-throughput RNA-seq was employed...
Metallothioneins (MTs) family comprises many isoforms, most of which are frequently dysregulated in a wide range cancers. However, the expression pattern and exact role each distinct MT isoform contributes to tumorigenesis, progression, drug resistance gastric cancer (GC) still unclear.Publicly available databases including Oncomine, Gene Expression Profiling Interactive Analysis (GEPIA), Kaplan-Meier plotter, SurvExpress, MethHC, cBioportal, GeneMANIA were accessed perform an integrated...
Three new sesquiterpenes: 4-acrylic-6-methyl-α-tetralone (1), ainsliaea acid A (2) and B (3), together with 8 known compounds (4-11) were isolated from the whole herb of Ainsliaea glabra their structures established by means 1D 2D NMR spectroscopy HR-ESIMS. Compounds 1-6 tested for inhibition nuclear factor kappa (NF-κB) in 293-NF-κB-luciferase reporter cell line induced lipopolysaccharide (LPS), compound 2 was further production tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), IL-6...
Poly(L‐lactic)‐acid (PLLA) as a drug carrier and water‐soluble timosaponin B‐II (TB‐II) model were selected to prepare drug‐loaded nanofibers by electrospinning. The average diameters of pure PLLA TB‐II‐loaded 212.5 ± 68.5, 219.7 57.8, 232.8 66.9, 232.9 97.7 nm, respectively. DSC XRD results demonstrated that TB‐II was well incorporated into the in an amorphous state. FI‐TR spectroscopy indicated had good compatibility with PLLA. In vitro release studies showed rapidly released from within 6...
This study aimed to investigate the effects of different concentrations Yiqi Xingnao (YQXN) oral liquid on cerebral ischemia/reperfusion (I/R) injury in rats and YQXN's related mechanisms.Rats were pretreated with 3 mL/kg, 6 12 mL/kg YQXN Naoxuekang capsule (NXK). Afterwards, I/R model established by a middle artery occlusion surgery. Neurological deficits, histopathology, infarction volume used evaluate YQXN. Evans blue terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling...