A5077044012- Potassium and Related Disorders
- Pulmonary Hypertension Research and Treatments
- Cardiovascular Function and Risk Factors
- Erythrocyte Function and Pathophysiology
- Respiratory viral infections research
- Pneumonia and Respiratory Infections
- Renin-Angiotensin System Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Electrolyte and hormonal disorders
- Emergency and Acute Care Studies
- Cardiovascular Effects of Exercise
- Sodium Intake and Health
- Blood Pressure and Hypertension Studies
- Respiratory Support and Mechanisms
- Biomarkers in Disease Mechanisms
- Neuroscience of respiration and sleep
- Ion Channels and Receptors
- Metabolomics and Mass Spectrometry Studies
- Ion Transport and Channel Regulation
- Cardiac Health and Mental Health
- Cardiovascular Health and Risk Factors
- Neurological Disorders and Treatments
- Gut microbiota and health
- Physiological and biochemical adaptations
- Blood properties and coagulation
First Affiliated Hospital of Guangzhou Medical University
2020-2025
State Key Laboratory of Respiratory Disease
2020-2025
Guangzhou Medical University
2020-2025
University of Hong Kong
2021-2024
Chinese University of Hong Kong
2021-2024
National Clinical Research
2024
Queen Mary Hospital
2023
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BACKGROUND: Mechanosensitive Piezo1 channel plays a key role in pulmonary hypertension (PH). However, the of Piezo2 PH remains unclear. METHODS: Endothelial cell (EC)–specific knockout ( flox/flox , Tek-Cre + ; EC−/− ) rats and primarily cultured microvascular ECs were used to determine PH. RESULTS: Data analysis publicly accessible single-cell RNA-sequencing data sets uncovered significant downregulation lung from patients with idiopathic arterial hypertension, which was verified lungs/ECs...
The association between lung microbiome and pulmonary hypertension (PH) remain unknown. This study aims to define the airway mycobiome signature its potential correlation with clinical parameters of PH. Overall, 244 patients PH 120 healthy controls (CON) were recruited from three independent centers. group was divided into subgroups not using antibiotics or corticosteroids (non-ANT/CORT), those ANT, CORT, ANT + CORT within 1 month, classification (Groups 1, 3, 4), World Health Organization...
Abstract Background Risk factors that predispose the development of severe community-acquired pneumonia (CAP) among pediatric CAP patients different age ranges are yet to be identified. Methods We retrospectively analyzed in-patients (< 6 years old) diagnosed with in our hospital. subdivided into four groups months, months-1 year, 1–2 years, and 2–6 years). Their medical records, including demographic information, clinical features, laboratory findings, chest radiographic reports, were...
Hypokalaemia is a side-effect of diuretics. We aimed to use machine learning identify features predicting hypokalaemia risk in hypertensive patients.Participants with hypertension the United States National Health and Nutrition Examination Survey 1999-2018 were included for analysis. To select most suitable algorithm, we tested evaluated five algorithms commonly employed epidemiological studies: Logistic Regression, k-Nearest Neighbor, Random Forest, Recursive Partitioning Regression Trees,...
BACKGROUND: Wheezing is a common clinical manifestation in children with pneumonia. However, the risk factors associated development of wheezing pneumonia and its features are not fully characterized, especially severe pneumonia.METHODS: We retrospectively recruited 1434 pediatric patients diagnosed between April 2012 September 2019 Fujian Maternity Child Health Hospital. The medical records regarding demographic information, manifestations, radiographic/laboratory findings, complications...
Chronic kidney disease (CKD) is a significant risk factor for pulmonary hypertension (PH), complication that adversely affects patient prognosis. However, the mechanisms underlying this association remain poorly understood. A major obstacle to progress in field lack of reliable animal model replicating CKD-PH. This study aimed establish stable rat We employed combined approach, inducing CKD through 5/6 nephrectomy and concurrently exposing rats high-salt diet. The model's hemodynamics were...
Background and Purpose The causal relationship between altered host microbiome composition, especially the respiratory tract microbiome, occurrence of pulmonary hypertension (PH) has not yet been studied. An increased abundance airway streptococci is seen in patients with PH compared healthy individuals. This study aimed to determine link elevated exposure Streptococcus PH. Experimental Approach dose‐, time‐ bacterium‐specific effects salivarius ( S. ), a selective streptococci, on...
We aimed to dissect the complex relations between depressive symptoms, antidepressant use, and constituent metabolic syndrome (MetS) components in a representative U.S. population sample. A total of 15,315 eligible participants were included from 2005 March 2020. MetS defined as hypertension, elevated triglycerides, reduced high-density lipoprotein cholesterol, central obesity, blood glucose. Depressive symptoms classified mild, moderate, or severe. Logistic regression was used evaluate...
Unlike the pulmonary artery (PA), pathophysiological changes of vein (PV) in development hypertension (PH) remain largely unknown. In this study, we comprehensively investigated structural and functional PV isolated from chronic hypoxia (CH; 10% O 2 , 21 days)-induced PH rat model (CHPH). Results showed that CH caused an increase right ventricular pressure but did not affect mean venous left atrial pressure. Similar to PA, vascular lumen stenosis medial thickening were also observed...
Abstract Background Pulmonary hypertension (PH) is a common complication in patients with chronic kidney disease (CKD), affecting prognosis. However, the pathogenesis not clear, and lack of stable animal model significant factor. Methods In this study, rat pulmonary (CKD-PH) was developed through 5/6 nephrectomy combined high-salt diet. The model’s hemodynamics pathological changes multiple organs were dynamically assessed. Lung tissues serum collected from rats to measure expression ACE2,...
Abstract Background： Pulmonary hypertension (PH) is a common complication in patients with chronic kidney disease (CKD), affecting prognosis. However, the pathogenesis not clear, and lack of stable animal model significant factor. Methods： In this study, rat pulmonary (CKD-PH) was developed through 5/6 nephrectomy combined high-salt diet. The model's hemodynamics pathological changes multiple organs were dynamically assessed. Lung tissues serum collected from rats to measure expression ACE2,...
To the Editor: Owing to heterogeneity of congenital heart disease-associated pulmonary hypertension (CHD-PH) disease and development vascular system in pediatric patients, management CHD-PH children is significantly different from that adults.[1] Early identification intervention are great significance for with CHD, non-invasive, accurate clinical tools urgently needed predict PH risk CHD. However, applicability current risk-scoring remains unclear. Furthermore, there presently no...
Abstract Right heart failure is the leading cause of death in pulmonary hypertension (PH), and echocardiography a commonly used tool for evaluating risk hierarchy PH. However, few studies have explored dynamic changes structural functional right during process Previous found that circulation coupling ventricular adaptation depends on degree pressure overload other factors. In this study, we performed time-dependent evaluation using transthoracic SU5416 plus hypoxia (SuHx)-induced PH rat...
Objective: Hypokalemia is a side-effect of diuretics. We aimed to use machine learning identify features predicting hypokalemia risk in hypertensive patients. Design and method: Participants with hypertension the United States National Health Nutrition Examination Survey 1999-2018 were included for analysis. To choose optimal algorithm, we tested five algorithms (Logistic Regression, k-Nearest Neighbor, Random Forest, Recursive Partitioning Regression Trees, eXtreme Gradient Boosting) 38...
Background and Purpose: Piezo1 is a crucial mechanical sensitive channel involved in vascular remodeling. However, the role of different types cells during development pulmonary hypertension (PH) induced by high flow largely unknown. Experimental Approach: Based on previously established protocols, we rat PH model left artery ligation (LPAL) for 2 5 weeks to mimic hemodynamic stress. Key Results: Results showed that right ventricular systolic pressure (RVSP) wall thickness were significantly...
BACKGROUND: Wheezing is a common clinical manifestation in children with pneumonia. However, the risk factors associated development of wheezing pneumonia and its features are not fully characterized, especially severe pneumonia.METHODS: We retrospectively recruited 1434 pediatric patients diagnosed between April 2012 September 2019 Fujian Maternity Child Health Hospital. The medical records regarding demographic information, manifestations, radiographic/laboratory findings, complications...
Abstract Introduction Diuretics are commonly used for the treatment of hypertension. Yet, hypokalaemia is a well-recognized adverse effect. Purpose To evaluate proportion patients taking indapamide who developed severe hypokalaemia, defined as requiring hospitalisation. Indapamide was by far most diuretic hypertension in Hong Kong. Methods We searched Kong Hospital Authority Clinical Data Analysis and Reporting System, which territory-wide database computerised medical records. All...