A5015442492- Sinusitis and nasal conditions
- Infectious Diseases and Mycology
- Diet and metabolism studies
- Nasal Surgery and Airway Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Mycobacterium research and diagnosis
- Gut microbiota and health
- Asthma and respiratory diseases
- Erythrocyte Function and Pathophysiology
- Antifungal resistance and susceptibility
- Physiological and biochemical adaptations
- Biomarkers in Disease Mechanisms
- Allergic Rhinitis and Sensitization
First Affiliated Hospital of Guangzhou Medical University
2024-2025
State Key Laboratory of Respiratory Disease
2024-2025
Guangzhou Medical University
2024-2025
Tianjin Medical University
2022-2024
Tianjin First Center Hospital
2022-2024
Institute of Hydroecology
2022
BACKGROUND: Mechanosensitive Piezo1 channel plays a key role in pulmonary hypertension (PH). However, the of Piezo2 PH remains unclear. METHODS: Endothelial cell (EC)–specific knockout ( flox/flox , Tek-Cre + ; EC−/− ) rats and primarily cultured microvascular ECs were used to determine PH. RESULTS: Data analysis publicly accessible single-cell RNA-sequencing data sets uncovered significant downregulation lung from patients with idiopathic arterial hypertension, which was verified lungs/ECs...
A growing body of evidence has elucidated that the gut microbiota a crucial impact on pathophysiological process atopic diseases. Eosinophilic chronic rhinosinusitis with nasal polyps (eCRSwNP) is local disease systemic immune response. Alterations in microbiome eCRSwNP patients remain largely undefined.
Background: An imbalance in the nasal microbiome is thought to be closely related development of diseases. However, microbiome-host interactions have rarely been studied.Objective: The aim this study was comprehensively investigate cross-talk between mucosal gene expression and microbiota patients with chronic rhinosinusitis polyps (CRSwNP) inverted papilloma (NIP).Methods: We performed a cross-sectional 43 CRSwNP, 27 NIP 34 controls using 5R 16S rRNA sequencing. A total 40 CRSwNP samples,...
<title>Abstract</title> Background An imbalance in the nasal microbiome is thought to be closely related development of diseases. However, microbiome-host interactions have rarely been studied. Objective The aim this study was comprehensively investigate cross-talk between mucosal gene expression and microbiota patients with chronic rhinosinusitis polyps (CRSwNP) inverted papilloma (NIP). Methods We performed a cross-sectional 43 CRSwNP, 27 NIP 34 controls using 5R 16S rRNA sequencing. A...
The oral administrated thiazolidinediones (TZDs) have been widely reported to alleviate experimental pulmonary hypertension (PH). However, previous studies mainly focused on their beneficial effects the cardiopulmonary vascular system but failed determine potential roles gut microenvironment. This study aims investigate of pioglitazone, an TZD drug, microbiome in classic PH rat models induced by hypoxia (HPH) or SU5416/hypoxia (SuHx-PH) and evaluate therapeutic supplementation selective...
Scedosporium apiospermum is a ubiquitous organism present in the environment and rarely identified rhinosinusitis. We report case of invasive rhinosinusitis with cannot identify pathogen traditional methods finally made definite diagnosis by metagenomic next-generation sequencing (mNGS) from biopsy sample. The resection pathological mass was performed low-temperature plasma radiofrequency ablation. 6 months continuous oral voriconazole treatment followed. patient asymptomatic no signs...