A5100783891- Sinusitis and nasal conditions
- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Antimicrobial Resistance in Staphylococcus
- Ferroptosis and cancer prognosis
- Nasal Surgery and Airway Studies
- IL-33, ST2, and ILC Pathways
- Infectious Diseases and Mycology
- Hearing, Cochlea, Tinnitus, Genetics
- Retinal and Optic Conditions
- Mycobacterium research and diagnosis
- Gut microbiota and health
- Circular RNAs in diseases
- Toxin Mechanisms and Immunotoxins
- Helicobacter pylori-related gastroenterology studies
- RNA modifications and cancer
- Plant-based Medicinal Research
- Bacterial biofilms and quorum sensing
- Pharmacological Effects of Natural Compounds
- Mast cells and histamine
- Tissue Engineering and Regenerative Medicine
- Plant-derived Lignans Synthesis and Bioactivity
- Medicinal Plants and Bioactive Compounds
- Electrospun Nanofibers in Biomedical Applications
- Brain Tumor Detection and Classification
Tianjin First Center Hospital
2011-2025
Tianjin Medical University
2011-2025
Luye Pharma (China)
2020-2024
Nankai University
2022-2024
Shandong Academy of Pharmaceutical Sciences
2024
Shandong University of Traditional Chinese Medicine
2023-2024
New York University Shanghai
2022-2023
East China Normal University
2022-2023
Institute of Hydroecology
2022-2023
Kunming Medical University
2023
Small colony variants (SCVs) of bacteria like Staphylococcus aureus are characterized by a reduced size and linked to increased antibiotic tolerance resistance. Their altered expression virulence factors, slow growing properties their ability form biofilms make the eradication SCVs challenging. In context biofilm-related infectious diseases involving S. SCVs, therapy targeting bacterial iron metabolism was evaluated. The combination iron-chelator deferiprone (Def) heme-analogue...
Objectives Increasing evidence indicates that the local microbiome can be used to predict host disease states. However, constructing models obtain better results with fewer features is still challenging. Methods In this study, we established a nasal database consisting of 132 chronic rhinosinusitis patients, 27 inverted papilloma and 45 control patients. 16S rRNA gene sequencing was identify species abundance bacteria in each sample, generated after low-abundance were eliminated. The...
Context: Icaritin (ICT), an intestinal metabolite of prenylflavonoids from Herba Epimedii, has been known to regulate many immune processes. But there are little studies ICT on hematopoietic function.Objective: We aimed investigate the improvement function in cyclophosphamide (CTX)-induced myelosuppression mice.Methods: Mice were given CTX (50 mg/kg) by i.p. for five days produce bone marrow depression model. 48 h after last treated with CTX, was administrated at 10 mg/kg/d p.o. days. Blood...
Background and Purpose Acute kidney injury (AKI) is a rapid renal dysfunctional disease, for which no effective drugs or therapies are available to improve prognosis. Loganetin natural product with unknown bioactivities. Here, we identified new protective effect mechanism of in mouse model AKI induced by rhabdomyolysis. Experimental Approach was using glycerol i.m. injection mice models. Thirty minutes 24 48 hr after glycerol, the received 2 18 mg·kg −1 i.p. respectively. Then blood were...
Although dynamics and uses of modified nanoparticles (NPs) as orally administered macromolecular drugs have been researched for many years, measures molecule stability aspects related to important transport-related mechanisms which assessed in vivo remain relatively under characterized. Thus, our aim was develop a novel type oral-based delivery system insulin overcome barriers studying the stability, transport mechanisms, efficacy system.NPs we developed tested were composed (INS),...
The mechanism of olfactory disorder (OD) in patients with COVID-19 is unclear. Our study aimed to elucidate the relationships between inflammatory factors and OD a sample infected Omicron variant, high vaccination rate China.The Sniffin' Sticks 12-item test was performed cross-sectional 148 recovered who were variant evaluate severity. We compared demographic, laboratory, clinical data.A total enrolled. A 129 cases detected. Increased inflammation contributed severity, especially adult...
A growing body of evidence has elucidated that the gut microbiota a crucial impact on pathophysiological process atopic diseases. Eosinophilic chronic rhinosinusitis with nasal polyps (eCRSwNP) is local disease systemic immune response. Alterations in microbiome eCRSwNP patients remain largely undefined.
The rapid and precise acquisition of the agricultural plastic greenhouse (PG) spatial distribution is essential in understanding PG usage degradation, ensuring production, protecting ecological environment human health. It great practical significance to realize effective utilization remote sensing images field improve extraction accuracy data. In this study, Landsat operational land imager (OLI) were used as data sources, Shandong Province, which has largest China, was selected study area....
With the rapid aging of population, control age-related disease susceptibility and prognosis faces greater challenges. There is an urgent need for a strategy to maintain vitality elderly people. In this study, effect Renshen Guben (RSGB) oral liquid was investigated on accelerated mice model thyrotoxicosis by conventional detection methods combined with multiomics technology. The results showed that RSGB increased number neutrophils lymphocytes, enhanced function levels complement...
Abstract Recent studies have shown that mast cells are involved in pathophysiologic processes of chronic inflammation. However, little is known about the distribution nasal polyps, which a inflammatory disease upper airways. Biopsy specimens from patients with polyps (n = 20) and control without 8) were included this study. The was determined by immunohistochemistry. Meanwhile, we detected expression chemokines (CCL5, CCL11, CX3CL1, IL‐8, IL‐6) epithelial normal mucosa polyps. In addition,...
Nasal polyposis is a chronic inflammatory disease of the nasal mucosa. The etiology and mechanisms formation polyps are still not clear. Interleukin (IL)-18 novel proinflammatory cytokine that plays important roles in regulating immune responses. However, presence IL-18 human mucosa its process has been studied yet. In this study, it was first time to investigate expression polyps, potential function polyps. Surgical samples were analyzed by Western blot immunohistochemistry evaluate...
Abstract Purpose It is of obvious interest to identify clinical prognosis-related oncogenes in HNSCC (head and neck squamous cell carcinoma). Methods Based on the available datasets within TCGA (The Cancer Genome Atlas) GEO (Gene Expression Omnibus) databases, potential mechanism action SEC61G ( SEC61 translocon subunit gamma) gene tumorigenesis was explored by several bioinformatics approaches. Results There a higher expression level primary tumor tissues than normal tissues. Moreover,...
Ethnopharmacological relevance: Jingfang Granule (JFG) is a classical traditional Chinese medicine (TCM) prescription to empirically treat skin disease such as urticaria in TCM clinical practice. However, the potential mechanisms of JFG on are not fully evaluated.Aim study: The aim this study investigate mechanism through an OVA/aluminum hydroxide induced mice model.Materials and methods: KM were injected intraperitoneally (i.p.) with OVA/aluminium establish model. After administered JFG,...
Antidepressants, while effective in treating depression and anxiety disorders, also induce deficits sensory (particularly auditory) processing, which turn may exacerbate psychiatric symptoms. How antidepressants cause auditory signature remains largely unknown. Here, we found that fluoxetine-treated adult female rats were significantly less accurate when performing a tone-frequency discrimination task compared with age-matched control rats. Their cortical neurons responded selectively to...
This paper is concerned with the Cauchy problem connected Laplace equation. We investigate denseness of harmonic polynomials and propose a numerical method for approximating solution to problem. The convergence stability are analyzed suitable choice regularization method. Numerical experiments also presented show effectiveness our