A5100352814- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immune cells in cancer
- Abdominal Trauma and Injuries
- Immune Response and Inflammation
- Abdominal vascular conditions and treatments
- Immune Cell Function and Interaction
- Pancreatitis Pathology and Treatment
- Liver Disease and Transplantation
- Coronary Interventions and Diagnostics
- Blood Pressure and Hypertension Studies
- Inflammasome and immune disorders
- Glioma Diagnosis and Treatment
- Abdominal Surgery and Complications
- Immunotherapy and Immune Responses
- Pancreatic and Hepatic Oncology Research
- Macrophage Migration Inhibitory Factor
- Vascular anomalies and interventions
- Hernia repair and management
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Inflammatory Biomarkers in Disease Prognosis
- Acupuncture Treatment Research Studies
- Appendicitis Diagnosis and Management
- Lipid metabolism and disorders
- Antibiotic Use and Resistance
- Aquaculture disease management and microbiota
Shanghai Jiao Tong University
2023-2025
Nanjing University
2019-2024
Nanjing General Hospital of Nanjing Military Command
2019-2024
Dalian Medical University
2024
First Affiliated Hospital of Dalian Medical University
2024
Hunan Normal University
2023-2024
Nanjing Medical University
2020-2024
Jiangsu Province Hospital
2024
Hebei General Hospital
2024
Wuhan General Hospital of Guangzhou
2024
Microvascular endothelial damage caused by intestinal ischemia‒reperfusion (II/R) is a primary catalyst for microcirculation dysfunction and enterogenous infection. Previous studies have mainly focused on how neutrophil extracellular traps (NETs) ferroptosis cause epithelial injury, little attention has been given to NETs, from circulatory neutrophils, affect cells during II/R. This study aimed unravel the mechanisms through which NETs microvascular dysfunction. We first detected heightened...
Previous studies have revealed that triglyceride to high-density lipoprotein cholesterol ratio (TG/HDL-C) is one of major risk factors insulin resistance and diabetes. However, study on the association between TG/HDL-C diabetes mellitus (DM) limited, especially in Chinese people. This was undertaken investigate relationship incident a large cohort population.The present retrospective study. A total 114,787 adults from Rich Healthcare Group China, which includes all medical records for...
Abstract Increased neutrophil extracellular traps (NETs) formation has been found to be associated with intestinal inflammation, and it reported that NETs may drive the progression of gut dysregulation in sepsis. However, biological function regulation sepsis-induced barrier dysfunction are not yet fully understood. First, we both circulating biomarkers local infiltration intestine were significantly increased had positive correlations markers enterocyte injury abdominal sepsis patients....
Background: Hesperetin (HES), one of the major flavonoids that has various biological activities, such as anti-inflammatory and antioxidant may preserve intestinal barrier during sepsis. However, detailed mechanism remains unclear. Our previous studies confirmed neutrophil extracellular traps (NETs) jeopardize via a reactive oxygen species (ROS)-dependent pathway Therefore, we hypothesized HES inhibit NET formation protect function Methods: Mice were pretreated with (50 mg kg-1)...
Introduction Cluster of differentiation (CD) 44 is a non-kinase cell surface transmembrane glycoprotein critical for tumor maintenance and progression. Methods We conducted systematic analysis the expression profile genomic alteration CD44 in 33 types cancer. The immune characteristics were comprehensively explored by TIMER2.0 CIBERSORT. In addition, transcriptional landscape was examined at single-cell level. Then, Pseudotime trajectory gene performed using Monocle 2, CellChat utilized to...
Abstract Neutrophil extracellular trap (NET) has been confirmed to be related gut barrier injury during intestinal ischaemia–reperfusion (II/R). However, the specific molecular regulatory mechanism of NETs in II/R‐induced damage yet fully elucidated. Here, we reported increased infiltration accompanied by elevated inflammatory cytokines, cellular necroptosis and tight junction disruption intestine human II/R patients. Meanwhile, aggravated Caco‐2 epithelial cell necroptosis, impairing...
Background: Acute mesenteric ischemia (AMI) is a rare life-threatening condition, especially for the patients with transmural intestinal necrosis (TIN). However, optimal time surgical intervention controversial. As series study, this study aimed to identify outcomes and clinical characteristic of TIN.Methods: Clinical data 158 AMI from January 2010 December 2017 were retrospectively analyzed in national gastrointestinal referral center China confirm predictors TIN.Results: According results...
Achieving rapid hemostasis in complex and deep wounds with secluded hemorrhagic sites is still a challenge because of the difficulty delivering hemostats to these sites. In this study, Janus particle, SEC-Fe@CaT dual-driven forces, bubble-driving, magnetic field– (MF–) mediated driving, was prepared via situ loading Fe 3 O 4 on sunflower sporopollenin exine capsule (SEC), followed by growth flower-shaped CaCO clusters. The bubble-driving forces enabled self-diffuse blood eliminate...
Abstract Background Glioma is the most common and lethal type of brain tumor, it characterized by unfavorable prognosis high recurrence rates. The reprogramming energy metabolism an immunosuppressive tumor microenvironment (TME) are two hallmarks tumors. Complex dynamic interactions between neoplastic cells surrounding can generate TME, which accelerate malignant progression glioma. Therefore, crucial to explore associations TME identify new biomarkers for glioma prognosis. Methods In our...
The clearance of apoptotic cells known as efferocytosis is the final stage apoptosis, and includes recognition, phagocytosis, degradation cells. maintenance tissue homeostasis requires daily elimination billions from human body via process efferocytosis. Accordingly, aberrations in underlie a growing list diseases, including atherosclerosis, cancer, infections. During initial phase “Eat-Me” signals are exposed recognized by phagocytes either directly through phagocyte receptors or indirectly...
Cigarette smoke is a prevalent respiratory toxicant that remains leading cause of death worldwide. induces inflammation in the lungs and airways contributes to development diseases such as lung cancer chronic obstructive pulmonary disease (COPD). Due presence aryl hydrocarbon receptor (AhR) ligands cigarette smoke, activation AhR has been implicated driving this inflammatory response. However, we have previously shown suppresses smoke-induced inflammation, but mechanism by which achieves its...
Self-medication with antibiotics (SMA) among children is a common practice in low-income and middle-income countries, which has accelerated antibacterial abuse.This study aimed to estimate the prevalence associated factors of SMA China, including parents' knowledge, attitudes, practices towards antibiotic use.A cross-sectional based on structured questionnaire survey parents was conducted Nantong between July September 2020. A total 1699 respondents participated. Information participants'...
Infection with the rabies virus (RABV) results in a 100% lethal neurological disease once symptoms develop. Post-exposure prophylaxis (PEP) consists of combination vaccination and anti-rabies immunoglobulins (RIGs); it is effective if administered early after exposure. Because its limited availability, alternatives for RIGs are needed. To that end, we evaluated panel 33 different lectins their effect on RABV infection cell culture. Several lectins, either mannose or GlcNAc specificity,...