A5100367251- Cytokine Signaling Pathways and Interactions
- Psoriasis: Treatment and Pathogenesis
- Immune Cell Function and Interaction
- Tuberculosis Research and Epidemiology
- Immune Response and Inflammation
- Garlic and Onion Studies
- Antimicrobial Peptides and Activities
- T-cell and B-cell Immunology
- Immune cells in cancer
- Insect symbiosis and bacterial influences
- Immunotherapy and Immune Responses
- Antibiotic Use and Resistance
- Aquaculture disease management and microbiota
- Invertebrate Immune Response Mechanisms
- NF-κB Signaling Pathways
- Vector-borne infectious diseases
- Cancer Immunotherapy and Biomarkers
- Reproductive System and Pregnancy
- IL-33, ST2, and ILC Pathways
- Fungal Plant Pathogen Control
- CAR-T cell therapy research
- Pharmacological Effects of Natural Compounds
- Bacterial Identification and Susceptibility Testing
- Atherosclerosis and Cardiovascular Diseases
- Immunodeficiency and Autoimmune Disorders
Chongqing Cancer Hospital
2024
Henan Cancer Hospital
2024
Zunyi Medical University
2022-2024
University of California, Irvine
2024
Soochow University
2024
Chongqing University
2024
Zhengzhou University
2024
Lianyungang Maternal and Children’s Hospital
2024
Harvard Pilgrim Health Care
2020-2023
Harvard University
2020-2023
<h3>Importance</h3> Broad-spectrum antibiotics are recommended for all patients with suspected sepsis to minimize the risk of undertreatment. However, little is known regarding net prevalence antibiotic-resistant pathogens across community-onset or outcomes associated unnecessarily broad empiric treatment. <h3>Objective</h3> To elucidate epidemiology and both undertreatment overtreatment in culture-positive sepsis. <h3>Design, Setting, Participants</h3> This cohort study included 17 430...
IL-17-producing Th17 cells have gradually become considered as key factors in the pathogenesis of many autoimmune diseases, including multiple sclerosis (MS). Although involvement certain microRNAs development MS has been reported, their role Th17-driven autoimmunity is still poorly understood. In this study, we identified microRNA (miR)-15b an important factor Th17-associated effects and determined that expression miR-15b significantly downregulated patients mice with experimental...
In exploring persistent infections and malignancies, a distinctive subgroup of CD8+ T cells, progenitor exhausted (Tpex) has been identified. These Tpex cells are notable for their remarkable self-renewal rapid proliferation abilities. Recent strides in immunotherapy have demonstrated that expand differentiate into responsive thus underscoring critical role the immunotherapeutic retort. Clinical examinations further clarified robust positive correlation between proportional abundance...
Rheumatoid arthritis (RA) is characterized by inflammatory cell infiltration, fibroblast‐like synoviocytes (FLS) invasive proliferation, and joint destruction. Cyclic GMP‐AMP synthase (cGAS) a cytosolic DNA sensor that induces immune activation. In this study, we examined whether cGAS plays role in RA FLS. was overexpressed RA‐FLS compared with OA TNF α stimulation induced expression Overexpression of promoted the proliferation knockdown inhibited overexpression enhanced production...
Abstract Aims The widespread use of immune checkpoint inhibitors (ICIs) has demonstrated significant survival benefits for cancer patients and also carries the risk immune-related adverse events. ICI-associated myocarditis is a rare serious event with high mortality rate. Here, we explored mechanism underlying myocarditis. Methods results Using peripheral blood ICI therapy ICI-treated mice transplanted tumours, dissect cell subsets inflammatory factors associated Compared to control group,...
Nosiheptide, a potent bicyclic member of the family thiopeptide antibiotics, possesses distinctive l-Trp-derived indolyl moiety. The way in which this moiety is incorporated into ribosomally synthesized and post-translationally modified remains poorly understood. Here, we report that NosK, an α/β-hydrolase fold protein, mediates transfer from NosJ, discrete thiolation to linear pentathiazolyl peptide intermediate rather than its genetically encoded untreated precursor. This results enzymatic...
Interleukin (IL) -35 is an anti-inflammatory cytokine which exerts various beneficial effects on autoimmune diseases. However, whether IL-35 plays a role in endotoxin induced hepatitis demands clarification. This study aims to reveal the effect and mechanism of liver injury. Acute hepatic injury was by D-galactosamine (D-GalN, 400 mg/kg) lipopolysaccharide (LPS, 5 μg/kg) administration mice. treatment ameliorated D-GalN/LPS dose dependent manner as shown histological examination, ALT...
Abstract A total of 705 rodents from 6 provinces and autonomous regions mainland People's Republic China were tested by PCRs for tick-borne agents (Anaplasma phagocytophilum, Borrelia burgdorferi sensu lato, spotted fever group rickettsiae, Francisella tularensis). Infection rates 5.5%, 6.7%, 9.1% 5.0%, respectively. Eighteen (2.6%) 10 species positive 2 or 3 agents. Sequence analysis PCR products confirmed the presence genotypes detected These findings demonstrate that these cocirculate a...
The purpose of this study was to evaluate burn-related variations inflammation and immunity. Fifty-five mice were divided randomly into sham burn groups. Eighty-seven hospitalized patients also reviewed. In mice, neutrophils monocytes elevated significantly on post day (PBD 1). Lymphocytes reduced PBDs 1 3. Levels serum tumor necrosis factor-α interleukin-6 highest PBD 1. Interleukin-1β levels the On 3, CD4CD25T regulatory cells/CD4 cells in spleen higher. 1, 7, 14, percentage splenic...
Acute respiratory distress syndrome (ARDS) is characterized by an uncontrollable cytokine storm, which associated with high mortality due to lack of effective treatment. Regulatory T cells (Tregs) play indispensable role in maintaining immune homeostasis and CD39 considered as a functional cell marker Tregs. In this study, we aimed evaluate the effect CD39+ Tregs on acute lung injury (ALI) investigate frequency ARDS patients. We found that after lipopolysaccharide (LPS) treatment, CD39-/-...
The potential anti-inflammatory bioactivities of β-hydroxyisovalerylshikonin (β-HIVS) remain largely unknown.This study investigated the effects and underlying mechanisms β-HIVS.RAW 264.7 cells stimulated with LPS (100 ng/mL) for 24 h were treated non-cytotoxic doses β-HIVS (0.5 or 1 μM, determined by MTT Trypan blue staining), qRT-PCR FCM assay used to examine macrophage polarization transitions. Western blotting was evaluate activation AMPK/Nrf2 pathway. In vivo, C57BL/6 mice randomly...
The role of Non-POU-domain-containing octamer-binding protein (NONO) in the formation and development angiotensin II (Ang II)-induced abdominal aortic aneurysm (AAA) apolipoprotein E-knockout (ApoE-/- ) mice is still unknown. In Part I, level NONO was suggestively greater AAA tissues compare to that normal aortas. II, 20 ApoE-/- male were used examine transfection efficiency lentivirus by detecting GFP fluorescence. III, arbitrarily separated into two groups: one control group without Ang...
The aim of this study was to investigate the possible protective effects diallyl trisulfide (DATS) against naphthalene-induced oxidative and inflammatory damage in livers lungs mice. Elevated serum alanine aminotransferase (ALT) aspartate (AST) levels showed significant hepatic after challenge with 100 mg/kg naphthalene. Hepatic malondialdehyde (MDA) contents activity myeloperoxidase (MPO) increased significantly, accompanying a decrease total superoxide dismutase (SOD) glutathione (GSH)...