A5060858699- Heat shock proteins research
- Ubiquitin and proteasome pathways
- RNA Research and Splicing
- Cancer, Hypoxia, and Metabolism
- Cellular and Composite Structures
- Cancer-related Molecular Pathways
- Muscle Physiology and Disorders
- interferon and immune responses
- Signaling Pathways in Disease
- Mechanical Behavior of Composites
- Autophagy in Disease and Therapy
- Sirtuins and Resveratrol in Medicine
- Adipose Tissue and Metabolism
- DNA Repair Mechanisms
- Cancer, Lipids, and Metabolism
- MRI in cancer diagnosis
- Research on Leishmaniasis Studies
- Cancer Cells and Metastasis
- Structural Response to Dynamic Loads
- Effects and risks of endocrine disrupting chemicals
- Chronic Myeloid Leukemia Treatments
- Parasitic infections in humans and animals
- Lipid metabolism and biosynthesis
- Phytochemistry and biological activity of medicinal plants
- RNA modifications and cancer
Sichuan University
2018-2025
West China Second University Hospital of Sichuan University
2022-2025
Imperial College London
2024
Dalian University of Technology
2019-2023
Dalian University
2021-2023
Huazhong Agricultural University
2021-2023
Gansu University of Traditional Chinese Medicine
2023
Xiamen University
2021-2022
State Key Laboratory of Biotherapy
2018-2021
Henan University
2021
Proteolysis targeting chimera (PROTAC) recruits an E3 ligase to a target protein induce its ubiquitination and subsequent degradation. We reported success in the development of two PROTACs (C3 C5) that potently selectively degradation Mcl-1 Bcl-2 (DC50 = 0.7 3.0 μM), respectively, by introducing cereblon-binding ligand pomalidomide Mcl-1/Bcl-2 dual inhibitors S1-6 Nap-1 with micromolar-range affinity. C3-induced translated into much more lethality Mcl-1-dependent H23 cells than most potent...
Metastasis is a major cause of colorectal cancer (CRC) mortality, but its molecular mechanisms are still not fully understood. Here, we show that upregulated DDX39B correlates with liver metastases and aggressive phenotypes in CRC. an independent prognostic factor associated poor clinical outcome CRC patients. We demonstrate Sp1 potently activates transcription by directly binding to the GC box promoter cells. overexpression augments proliferation, migration, invasion cells, while opposite...
Abstract Breast cancer is the most common in world. Relapse and metastasis are important factors endangering life of breast patients, but mechanism still unclear. The stabilization p53 essential for preventing carcinogenesis, ubiquitination one main ways to regulate stability p53. Tripartite motif-containing 31 (TRIM31) a new member TRIM family functions as an E3 ubiquitin ligase. It acts promoter or suppressor malignant processes multiple cancers. However, function TRIM31 progression...
Abstract Congenital heart disease (CHD) represents a major birth defect associated with substantial morbidity and mortality. Although environmental factors are acknowledged as potential contributors to CHD, the underlying mechanisms remain poorly understood. Bisphenol A (BPA), common endocrine disruptor, has attracted significant attention due its widespread use health risks. This study examined effects of maternal BPA exposure on fetal development in murine model. The findings indicated...
Di-(2-ethylhexyl)-phthalate (DEHP) is a common endocrine disruptor that causes very serious environmental pollution. Recent studies have described DEHP exerts detrimental effects on key processes of placental development, including implantation, differentiation, invasion, and angiogenesis. However, its the proliferation trophoblasts related regulatory mechanisms remain elusive. This study demonstrated maternal exposure significantly disrupted growth. Similarly, transcriptomic proteomic...
Ferulic acid promotes slow-twitch and inhibits fast-twitch myofiber formation <italic>via</italic> Sirt1/AMPK.
The increasing genomic complexity of acute myeloid leukemia (AML), the most common form leukemia, poses a major challenge to its therapy. To identify potent therapeutic targets with ability block multiple cancer-driving pathways is thus imperative. unique peptidyl-prolyl cis-trans isomerase Pin1 has been reported promote tumorigenesis through upregulation numerous pathways. Although key drug target for treating promyelocytic (APL) caused by fusion oncogene, much less known about role in...
Abstract Background For cancer therapy, the identification of both selective autophagy targets and small molecules that specifically regulate is greatly needed. Heat shock protein 70 (Hsp70) a recently discovered BH3 receptor forms protein‒protein interaction (PPI) with Bcl-2-interacting mediator cell death (Bim). Herein, specific inhibitor Hsp70-Bim PPI, S1g-2 , its analog S1 which Bcl-2-Bim disruptor, were used as chemical tools to explore role PPI in regulating mitophagy. Methods...
Sandwich structure is a lightweight with high specific strength and stiffness, as well excellent energy absorption load-carrying capacity. structures are widely used in aerospace, high-speed rail marine applications. Low-velocity impact of sandwich beam foam-filled sinusoidal corrugated core investigated by means theoretical derivations numerical calculations. A yield criterion to obtain an analytical solution the dynamic behavior champed beams cores under low-velocity impact. Numerical...
Tea is one of the most popular non-alcoholic beverages in world, and free amino acids, especially theanine, make a major contribution to umami taste tea. However, genetic basis variation acid content tea plants remains largely unknown. Here, we measured fresh leaves 174 accessions over two years using targeted metabolomics approach obtained genotype data via RNA sequencing. Genome-wide association studies were conducted investigate loci affecting acids. A total 69 quantitative trait (-log10...
<b><i>Background/Aims:</i></b> Adhesion-regulating molecule 1 (ADRM1), a receptor located on the 26S proteasome, is upregulated in many solid cancers. However, little known about its role acute leukemia (AL). <b><i>Methods:</i></b> We determined ADRM1 expression levels both untreated AL samples and cell lines using real-time polymerase chain reaction or Western blot analysis. Growth curves, colony formation assays, cycle apoptosis analyses,...
This study aimed to investigate the effect of arginine on expression slow myosin heavy chain (MyHC) I and its underlying mechanism in porcine skeletal muscle satellite cells. Our results showed that upregulated mRNA (1.54 ± 0.08; p < 0.01) protein (2.01 0.01; 0.001) levels MyHC I. We also Akirin2 (1.35 0.1; 0.05) increased NO content (1.56 0.04; 0.001). siRNA abolished arginine-induced upregulation increase content. In addition, significantly phospho-AMP-activated kinase (AMPK)/AMPK level...
Breast cancer is one of the leading causes death in women. Due to existence a small fraction stem cell-like subpopulations, some breast subtypes exhibit very high malignancy and resistance multiple therapies. The underlying mechanisms how these acquire properties progress more aggressively remain largely unknown. Zinc finger protein 32 (ZNF32), newly discovered transcription factor, has been reported be associated with progression. However, many questions about its target genes exact...
The objective of this study was to investigate effects active immunization against Akirin2 on muscle fiber-type composition in pigs. Here we showed that the titer antibody pigs immunized with porcine (pAkirin2) significantly increased. Active pAkirin2 decreased succinic dehydrogenase and malate activities increased lactate activity longissimus dorsi MyHC I IIa mRNA expressions protein expression IIb as well fast-MyHC. nuclear factors activated T cells c1 (NFATc1), transcriptional coactivator...
Abstract Based on our previously reported Bcl‐2/Mcl‐1 dual inhibitor 4‐thiomorpholinyl‐2‐cyano‐3‐amidinophenalenone ( A1 ) that simultaneously occupies the p2 and p4 hydrophobic pockets of Bcl‐2 Mcl‐1, we optimized molecules with different bond angles groups extending to pocket bulky explore p2. Research structure–activity relationship resulted in a new derivative B4 is capable occupying both more deeply completely than , K i values determined by fluorescence polarization assay (FPAs)...