A5025295460- Microbial Metabolic Engineering and Bioproduction
- Biofuel production and bioconversion
- Aquaculture disease management and microbiota
- Animal Virus Infections Studies
- Enzyme Catalysis and Immobilization
- Virus-based gene therapy research
- Bacteriophages and microbial interactions
- Enzyme Structure and Function
- Heat shock proteins research
- interferon and immune responses
- Amino Acid Enzymes and Metabolism
- Antimicrobial Peptides and Activities
- biodegradable polymer synthesis and properties
- Viral Infections and Vectors
- Aquaculture Nutrition and Growth
- Composting and Vermicomposting Techniques
- Viral Infectious Diseases and Gene Expression in Insects
- Ubiquitin and proteasome pathways
- RNA Interference and Gene Delivery
- Autophagy in Disease and Therapy
- Biochemical Acid Research Studies
- Phytase and its Applications
- Plant Virus Research Studies
- RNA and protein synthesis mechanisms
- Invertebrate Immune Response Mechanisms
Gansu Provincial Hospital
2025
South China Agricultural University
2018-2024
Research Institute of Highway
2024
ITS (United Kingdom)
2024
Xinjiang Industry Technical College
2024
Qingdao National Laboratory for Marine Science and Technology
2023
Key Laboratory of Guangdong Province
2022
Dalian University
2020-2021
Dalian University of Technology
2020-2021
Institute of Oceanology
2011-2019
Microbial processes for commodity chemicals have focused on reduced products and anaerobic conditions where substrate loss to cell mass CO 2 are minimal product yields high. To facilitate expansion into more oxidized chemicals, Escherichia coli W3110 was genetically engineered acetate production by using an approach that combines attributes of fermentative oxidative metabolism (rapid growth, external electron acceptor) a single biocatalyst. The resulting strain (TC36) converted 333 mM...
Natural polyphenols have been reported much attention in recent years for their hypoglycemic actions and diabetes‐related pathologies. Free simple can be digested absorbed the small intestine, while complex are utilized by intestinal flora large intestine. Microbial metabolites of may regulate production bile acids, thus affecting metabolism host. Polyphenols generally reduce postprandial blood glucose level via inhibition α ‐amylase ‐glucosidase absorption release from liver, stimulation...
Abstract BACKGROUND: The crude glycerol from biodiesel production represents an abundant and inexpensive source which can be used as raw material for lactic acid production. first aim of this investigation was to select a strain suitable producing with high concentration productivity. second obtain the optimum fermentation conditions, basis large‐scale lactate in future. RESULTS: Eight bacterial strains, could aerobically convert acid, were screened soil samples. One AC‐521, synthesized...
Largemouth bass (Micropterus salmoides) is an important commercial fish farmed in China. Challenges related to diseases caused by pathogens, such as iridovirus, have become increasingly serious. In 2017, we detected iridovirus-infected diseased largemouth Zunyi, Guizhou Province. The isolated virus was identified infectious spleen and kidney necrosis (ISKNV)-like (ISKNV-ZY). ISKNV-ZY induces a cytopathic effect after infecting mandarin brain (MFB) cells. Abundant hexagonal particles were...
Singapore grouper iridovirus (SGIV) is an enveloped virus causing heavy economic losses to marine fish culture. The envelope fractions of SGIV were separated from the purified virions by Triton X-100 treatment, and subjected 1-DE-MALDI-TOF/TOF-MS/MS LC-MALDI-TOF/TOF-MS/MS analysis. A total 19 virus-encoded proteins identified in this study 73.7% (13/17) them predicted be membrane proteins. Three viral uniquely 1-DE-MALDI, whereas another ten only LC-MALDI, with six both workflows. VP088 was...
The chaperone heat shock protein 70 (Hsp70) is crucial for avoiding misfolding under stress, but also up-regulated in many kinds of cancers, where its ability to buffer cellular stress prevents apoptosis. Previous research has suggested Hsp70 interacts with pro-apoptotic Bcl-2 family proteins, including Bim and Bax. However, a definitive demonstration this interaction awaits, insights into the structural basis molecular mechanism remain unclear. Earlier studies have identified homology 3...
A C‐type lectin‐like protein (Ec‐ CTLP ) was cloned from the grouper Epinephelus coioides . The full‐length cDNA of Ec‐ composed 905 bp with a 522 open reading frame that encodes 174‐residue protein. putative amino acid sequence contains signal peptide 19 residues at N‐terminus and CLECT domain Cys43 to Arg169 conserved imperfect WND (Trp‐Asn‐Asp) motif. homologous identity deduced sequences is 32 42% other fishes. expression differently upregulated in E. spleen (germline stem) cells after...
Singapore grouper iridovirus (SGIV) is a major pathogen that causes heavy economic losses to the aquaculture industry in China and Southeast Asian countries. In present study, viral envelope protein, VP39, encoded by SGIV ORF39L, was identified characterized. ORF39L found all sequenced iridoviruses now considered be core gene of family Iridoviridae. classified as late during vitro infection using reverse transcription–polymerase chain reaction, western blotting, drug inhibition analysis. An...