About
Contact & Profiles
A5064078896
Research Areas
- Metal complexes synthesis and properties
- Chronic Myeloid Leukemia Treatments
- Research on Leishmaniasis Studies
- Insect Resistance and Genetics
- Cell death mechanisms and regulation
- Protein Structure and Dynamics
- Protein Kinase Regulation and GTPase Signaling
- Heat shock proteins research
Dalian University
2021
Dalian University of Technology
2021
10.1038/s41375-021-01283-5
article
EN
Leukemia
2021-05-18
10.1016/j.ejmech.2021.113452
article
EN
European Journal of Medicinal Chemistry
2021-04-15
Selective Mcl-1 inhibitors may overcome the drug resistance caused by current anti-apoptotic Bcl-2 protein in tumors with overexpression. Based on previously discovered compounds a 3-phenylthiophene-2-sulfonamide core moiety, this work, we have obtained new improved binding affinity and/or selectivity under guidance of structure-based design. The most potent achieved sub-micromolar affinities to (Ki ∼ 0.4 μM) and good cytotoxicity (IC50 < 10 several tumor cells. 15N-heteronuclear...
10.1021/acs.jmedchem.1c00690
article
EN
Journal of Medicinal Chemistry
2021-07-06
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