A5023211044- Thyroid Cancer Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Thyroid and Parathyroid Surgery
- Head and Neck Anomalies
- Colorectal and Anal Carcinomas
- Colorectal Cancer Surgical Treatments
- Esophageal and GI Pathology
- Gastrointestinal Tumor Research and Treatment
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Foreign Body Medical Cases
- Metastasis and carcinoma case studies
- RNA modifications and cancer
- Esophageal Cancer Research and Treatment
- Thyroid Disorders and Treatments
- Toxoplasma gondii Research Studies
- Urinary and Genital Oncology Studies
- Hedgehog Signaling Pathway Studies
- Atherosclerosis and Cardiovascular Diseases
- Gastrointestinal disorders and treatments
- Peptidase Inhibition and Analysis
- Immune cells in cancer
- Greenhouse Technology and Climate Control
- S100 Proteins and Annexins
- FOXO transcription factor regulation
Guangdong Academy of Medical Sciences
2011-2025
Guangdong Provincial People's Hospital
2007-2025
Southern Medical University
2024-2025
Nanjing University of Chinese Medicine
2022-2024
Jiangsu Province Hospital
2022-2024
Shenzhen Technology University
2024
First Hospital of China Medical University
2020
China Medical University
2020
Guangdong General Hospital
2011-2018
Sun Yat-sen University
2006
Hepatocytes show endoplasmic reticulum (ER) stress when exposed to lipotoxic stimuli such as hyperlipidemia. Recent work has revealed that AMP- activated protein kinase (AMPK) can mitigate ER stress. In this study we investigated the impact of AMPK on lipid-induced in hepatocytes and its underlying molecular mechanism. Treatment with 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR), an agonist, or overexpression a constitutively active significantly suppressed lipid-mediated stress,...
Abstract Introduction Endoscopic submucosal dissection (ESD) is a preferred treatment option for superficial esophageal squamous cell carcinoma (SESCC). However, only few studies compared long-term survival outcomes of ESD with surgery, especially T1b SESCC. This study the overall (OS), disease-free (DSS), recurrence-free (RFS), and complication rates both, to evaluate value in patients Methods We reviewed who underwent ( n = 47) or surgery 73) SESCC at Affiliated Hospital Nanjing University...
Large‐volume central lymph node metastasis (large-volume CLNM) is associated with high recurrence rate in papillary thyroid carcinoma (PTC) patients. However, sensitivity investigating large-volume CLNM on preoperative ultrasonography (US) not high. The aim of this study to investigate the clinical factors N0 PTC We reviewed 976 patients undergoing total thyroidectomy dissection during 2017 2019. LNM was 4.1% (40 967 patients). Multivariate analysis showed that male gender and young age...
Background: Lymph node metastasis of papillary thyroid carcinoma (PTC) was a significant risk factor local recurrence and distant metastasis, our study aimed to identify predictive factors skip in PTC, helping surgeons build strategy when facing patients N1b stage with clinical central lymph node-negative.
Abstract Background RNA methylation, an important reversible post-transcriptional modification in eukaryotes, has emerged as a prevalent epigenetic alteration. However, the role of m6A reader YTH domain family 2 (YTHDF2) not been reported anaplastic thyroid cancer (ATC) and its biological mechanism is unclear. Methods The relationship between YTHDF2 expression ATC was determined using data sets tissue samples. A range analytical techniques were employed to investigate regulatory ATC,...
AIM:To examine matrix metalloproteinase-2 (MMP-2) expression in gastric cancer tissues and to evaluate its relationship with lymph node micrometastasis. METHODS:The authors studied 850 nodes resected from 30 patients carcinoma who underwent gastrectomy lymphadenectomy using reverse transcription polymerase chain reaction (RT-PCR) assay addition H-E staining.MMP-2 of the tumor was detected by immunohistochemical technique (EliVision TM plus). RESULTS: MMP-2 positive 21 (70%) cases negative 9...
To evaluate the risk factors for lateral lymph node metastasis in patients with advanced low rectal cancer, order to make effective selection of who could benefit from dissection, as well relationship local recurrence and survival cancer.A total 96 consecutive underwent curative surgery pelvic lymphadenectomy lower cancer were retrospectively analyzed. The relation clinicopathologic characteristics, was identified.Lateral observed 14.6% (14/96) cancer. Lateral detected 10 (25.0%) 40 tumor...
Background: Lymph node metastasis (LNM) has been a significant predictor for local recurrence and distant in papillary thyroid carcinoma (PTC). However, the clinical predictors conventional (CPTC) with lateral lymph (LLNM) have yet to be established. Our work aimed effectively identify risk factors of LLNM CPTC, helping surgeons devise better individualized therapy strategies. Methods: We retrospectively analyzed 652 patients who were diagnosed CPTC Department General Surgery at Guangdong...
The aim of this study was to identify the risk factors associated with lymph nodes posterior right recurrent laryngeal nerve (LN-prRLN) metastasis in patients papillary thyroid carcinoma (PTC). A total 81 PTC who underwent total/near-total thyroidectomy LN-prRLN dissection Department General Surgery at Guangdong Hospital between June 2015 and August 2016 were assessed retrospectively. relations clinicopathologic characteristics analyzed by univariate multivariate logistic regression....
Background: The surgical approach toward unilateral papillary thyroid carcinoma (PTC) has been in controversy. One of the concerns is existence contralateral occult carcinoma, which could cause relapse and even lead to re-operation if not dealt with. This study aims find out risk factors related PTC, order facilitate decision for PTC. Methods: A total 921 PTC patients who underwent total/near-total thyroidectomy central lymph node dissection (CND) with/without lateral (LND) from January 2014...
<title>Abstract</title> <bold>INTRODUCTION: </bold>Endoscopic submucosal dissection (ESD) is a preferred treatment option for superficial esophageal squamous cell carcinoma (SESCC). However, only few studies compared long-term survival outcomes of ESD with surgery, especially T1b SESCC. This study the overall (OS), disearse free (DSS), recurrence-free survival(RFS), and complication rates both, To evaluate value in patients <bold>METHODS:</bold> We reviewed who underwent (n = 47) or surgery...
Accumulating evidence supports the early involvement of monocyte/macrophage recruitment to activated endothelial cells by leukocyte adhesion molecules during atherogenesis. CD40 and its ligand CD40L are highly expressed in vascular cells, but impact on monocyte related molecular mechanisms not fully understood. The present study was designed evaluate direct effect monocytic cell gain mechanistic insight into signaling coupling function proinflammatory response. Exposure cultured human aortic...
Background Thyroid nodules are a very common finding in the general population. Fine-needle aspiration (FNA) has been recommended as initial test for evaluation of thyroid nodules. The trend on reporting atypia undetermined significance (AUS) significantly increased, but malignant risk is still controversial among different studies. aim this study to investigate malignancy reported Bethesda category III (AUS/FLUS) FNA. Method We reviewed 272 papillary cancer (PTC) patients with suspicious...
Objective . The aim of this study was to identify the risk factors associated with central lymph node metastasis (CLNM) in patients clinically node-negative conventional papillary thyroid carcinoma (cN 0 CPTC). Methods A total 190 cN CPTC who underwent thyroidectomy prophylactic neck dissection (pCND) Department General Surgery at Guangdong Hospital between March 2014 and December 2015 were assessed retrospectively. relations CLNM clinicopathologic characteristics analyzed by univariate...
To evaluate the oncological outcomes of transanal local excision and need for immediate conventional reoperation in treatment patients with high risk T(1) rectal cancers.Twenty five cancers treated by at Guangdong General Hospital were analyzed retrospectively. Twelve received 13 underwent subsequent surgical rescue after within 4 wk. Differences recurrence rates 5-year overall survival between two groups analyzed. The prognostic value was also evaluated.The median follow-up period 62 mo....
<title>Abstract</title> <bold>Background</bold> RNA methylation, an important reversible post-transcriptional modification in eukaryotes, has emerged as a prevalent epigenetic alteration. However, the role of m6A reader YTH domain family 2 (YTHDF2) not been reported anaplastic thyroid cancer (ATC) and its biological mechanism is unclear.<bold>Methods</bold> The relationship between YTHDF2 expression ATC was determined through utilization data sets tissue samples. A range analytical...