A5101543753- Pharmacogenetics and Drug Metabolism
- Drug Transport and Resistance Mechanisms
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Nutritional Studies and Diet
- Retinoids in leukemia and cellular processes
- Dialysis and Renal Disease Management
- Endoplasmic Reticulum Stress and Disease
- Horticultural and Viticultural Research
- Plant Physiology and Cultivation Studies
- Cholesterol and Lipid Metabolism
- Sphingolipid Metabolism and Signaling
- Postharvest Quality and Shelf Life Management
- Advanced Computational Techniques and Applications
- Pancreatic function and diabetes
- Antioxidant Activity and Oxidative Stress
- RNA and protein synthesis mechanisms
- Pharmacological Effects and Toxicity Studies
- Autism Spectrum Disorder Research
- Chronic Kidney Disease and Diabetes
- Nuclear Materials and Properties
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Aortic aneurysm repair treatments
- Nuclear reactor physics and engineering
- Chemotherapy-induced organ toxicity mitigation
Hebei Academy of Agriculture and Forestry Sciences
2021-2025
China National Nuclear Corporation
2018-2024
Smithsonian Latino Center
2023-2024
Chongqing Medical University
2022-2024
Children's Hospital of Chongqing Medical University
2023-2024
China International Science and Technology Cooperation
2024
Institute of Pomology
2023-2024
Tianjin Medical University General Hospital
2016-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
Peking Union Medical College Hospital
2023
Objective: To analyze the epidemiological history, clinical manifestations, treatment and short-term prognosis of 31 cases 2019 novel coronavirus (2019-nCoV) infection in children from six provinces (autonomous region) northern China. Methods: A retrospective analysis symptoms, signs, laboratory examinations, chest imaging, 2019-nCoV was conducted. The patients were diagnosed between January 25th, 2020 February 21st, 21 hospitals 17 cities Shaanxi, Gansu, Ningxia, Hebei, Henan Shandong....
Acral melanoma is a dismal subtype of occurring in glabrous acral skin, and has higher incidence East Asians. We perform single-cell RNA sequencing for 63,394 cells obtained from 5 3 cutaneous samples to investigate tumor heterogeneity immune environment. define orthogonal functional cell clusters that are involved TGF-beta signaling, Type I interferon, Wnt Cell cycle, Cholesterol efflux signaling. Signatures enriched TGF-beta, cholesterol signaling significantly associated with good...
Chemodynamic therapy (CDT), a noninvasive strategy, has emerged as promising alternative to conventional chemotherapy for treating tumors. However, its therapeutic effect is limited by the amount of H2O2, pH value, hypoxic environment tumors, and it suboptimal tumor-targeting ability. In this study, tumor cell membrane-camouflaged mesoporous Fe3O4 nanoparticles loaded with perfluoropentane (PFP) glucose oxidase (GOx) are used microenvironment-adaptive nanoplatform ([email protected]2-G),...
Increasing evidence suggests that adenosine monophosphate-activated protein kinase (AMPK) exerts protective effects for cardiovascular diseases apart from the regulation of energy homeostasis. However, role AMPK and its underlying mechanism on macrophage foam cell formation are poorly understood. In this study, we sought to investigate potential in modulating cholesterol deposition by using murine macrophage-derived cells. Incubation with 5-aminoimidazole-4-carboxyamide ribonucleoside...
Hepatic metabolic derangements are key components in the development of fatty liver disease. AMP-activated protein kinase (AMPK) plays a central role controlling hepatic lipid metabolism through modulating downstream acetyl CoA carboxylase (ACC) and carnitine palmitoyl transferase 1 (CPT-1) pathway. In this study, cyanidin-3-O-β-glucoside (Cy-3-g), typical anthocyanin pigment was used to examine its effects on AMPK activation acid human HepG2 hepatocytes. Anthocyanin Cy-3-g increased...
Background: Retinol-binding protein 4 (RBP4) is an adipokine that plays decisive roles in glucose metabolism and insulin sensitivity. Elevated circulating RBP4 levels were reported to be associated with increased risk for cardiovascular disease, but the precise role of atherosclerotic diseases its mechanisms action remain elusive. Methods: Serum 1683 participants from South China evaluated occurrence major adverse events was followed up 5 years. Apolipoprotein E-deficient mice infected...
Recent studies have revealed the essential role of retinol binding protein 4 (RBP4) in insulin resistance. However, impact RBP4 on aberrant lipogenesis, common hepatic manifestation resistance states, and underlying mechanism remain elusive. The present study was designed to examine effect sterol regulatory element-binding (SREBP-1) lipogenesis. Treatment with human retinol-bound (holo-RBP4) significantly induced intracellular triglyceride (TAG) synthesis HepG2 cells this is...
Rationale: 7-Ketocholesterol (7-KC), a form of cholesterol oxidation product, plays an essential role in the atherogenesis animal models. Objective: We sought to determine association circulating 7-KC with clinical cardiovascular outcomes and total mortality patients stable coronary artery disease. Methods Results: measured plasma levels by high-performance liquid chromatography prospective cohort study 1016 (mean age, 63.2 years; male 61.1%) disease who were recruited from December 2008...
Hepatocytes show endoplasmic reticulum (ER) stress when exposed to lipotoxic stimuli such as hyperlipidemia. Recent work has revealed that AMP- activated protein kinase (AMPK) can mitigate ER stress. In this study we investigated the impact of AMPK on lipid-induced in hepatocytes and its underlying molecular mechanism. Treatment with 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR), an agonist, or overexpression a constitutively active significantly suppressed lipid-mediated stress,...
Retinol-binding protein 4 (RBP4), a novel adipokine secreted by adipocytes and the liver, has elevated levels in type 2 diabetes mellitus (T2DM). However, its association with human metabolic diseases remains controversial. The present study was designed to investigate associations of plasma RBP4 oxidative stress, inflammatory markers, syndrome (MetS) Chinese population.We evaluated cross-sectional sample 1748 men women aged 50 70 years Guangzhou using an in-house developed validated...
Pulp injury is one of the most common clinical diseases, and severe cases are usually associated with functional loss tooth, while current treatment modality only a cavity filling procedure without regeneration dentin-pulp complex, thus leading to devitalized brittle tooth. In this study, carbon dots (CDots) excellent biocompatibility prepared from ascorbic acid polyethyleneimine
Oxazaphosphorines, with the most representative members including cyclophosphamide, ifosfamide, and trofosfamide, constitute a class of alkylating agents that have broad spectrum anticancer activity against many malignant ailments both solid tumors such as breast cancer hematological malignancies leukemia lymphoma. Most oxazaphosphorines are prodrugs require hepatic cytochrome P450 enzymes to generate active moieties before manifesting their chemotherapeutic effects. Meanwhile, can also be...
Blood biomarkers are first-line tools for identifying periprosthetic joint infection (PJI). C-reactive protein (CRP) is currently recognized as the standard biomarker PJI diagnosis. Other recently reported novel biomarkers, including plasma fibrinogen, platelet count, monocyte/lymphocyte ratio (MLR), neutrophil/lymphocyte (NLR), and count/lymphocyte (PLR), have also shown promise in diagnosing PJI. This study aimed to evaluate whether these were superior CRP PJI.Patients who underwent...
<title>Abstract</title> This study systematically analyzed the distribution characteristics and developmental patterns of sugars organic acids in apricots, exploring accumulation metabolism acids, thus providing important information for improving fruit quality. High-performance liquid chromatography was used to determine sugar organic-acid contents distributions mature apricot fruits from 332 common seedlings 64 germplasm resources. The results showed that glucose sucrose are main were...
Abstract IL-25 or IL-17E is a member of IL-17 cytokine family and has immune-modulating activities. The role in maintaining lipid metabolic homeostasis remains unknown. We investigated the effects exogenous deficiency on hepatic accumulation. expression was examined paraffin-embedded tissue sections liver from patients livers mice. Mouse model steatosis induced by feeding high-fat diet (HFD). Extent as well cytokines, key enzymes for pathways, markers Kupffer cells/macrophages, droplet (LD)...
<b><i>Background:</i></b> Idiopathic pulmonary fibrosis (IPF) is a progressive and lethal fibrotic lung disease with an unknown aetiology. Persistent myofibroblast differentiation prominent feature of IPF. Cigarette smoking risk factor for IPF indicator poor prognosis. induces endoplasmic reticulum (ER) stress, it has been shown that ER stress promotes fibroblast-to-myofibroblast in fibrosis. In this study, we investigated whether cigarette smoke extract (CSE) via the...
Load forecast is the foundation of power system operation and planning. The results can guide economic dispatch security analysis. In order to improve accuracy load forecast, this paper proposes a forecasting model based on combination cuckoo search (CS) algorithm long short-term memory (LSTM) neural network. data are specific with time series characteristics periodicity, LSTM control information added or discarded through forgetting gate, so as realize function memorizing. Therefore, use...
Multiomics require concerted recording of independent information, ideally from a single experiment. In this study, we introduce RIMS-seq2, high-throughput technique to simultaneously sequence genomes and overlay methylation information while requiring only small modification the experimental protocol for DNA sequencing include controlled deamination step. Importantly, rate 5-methylcytosine is negligible thus does not interfere with standard data processing. Thus, RIMS-seq2 libraries whole-...
Arthropod-borne pathogens and parasites are major threats to human health global agriculture. They may directly or indirectly manipulate behaviors of arthropod vector for rapid transmission between hosts. The largest genus plant viruses, Begomovirus, is transmitted exclusively by whitefly (Bemisia tabaci), a complex at least 34 morphologically indistinguishable species. We have previously shown that plants infected with the tomato yellowleaf curl China virus (TYLCCNV) its associated...