To determine the prevalence and symptom pattern of pathologic esophageal acid reflux (PEAR) in patients with functional dyspepsia (FD) using Rome III criteria, to explore value a proton pump inhibitor (PPI) test distinguishing those without PEAR among FD patients.Consecutive who fulfilled criteria predominant typical symptoms (i.e., heartburn or regurgitation) were enrolled. All underwent upper endoscopy an ambulatory 24-h pH monitoring. was defined as percentage total time for which <4...

Dynamic interactions between the host and gastrointestinal microbiota play an important role for local systemic immune homeostasis. Helminthic parasites modulate response, resulting in protection against autoimmune disease but also increased susceptibility to pathogen infection. The underlying mechanisms remain largely unknown. We showed that type 2 response enteric Nippostrongylus brasiliensis infection mice was associated with altered intestinal mucin AMP expression shifts composition....

Liver fibrosis is a reversible wound-healing response that occurs after liver injury. NADPH oxidases (NOXs) and reactive oxygen species (ROS) which are expressed in hepatocytes (HCs), hepatic stellate cells (HSCs), Kupffer (KCs) play an important role the development of fibrosis. In vitro studies, we had shown ursolic acid (UA) could reverse by inhibiting activation NOX-mediated fibrotic signaling networks HSCs. this study, verified UA alleviate CCl4-induced reducing expression NOXs/ROS HCs,...

Abstract Objectives/Hypothesis: To investigate whether the pepsin immunohistochemical (IHC) staining of laryngeal mucosa epithelia is an available test for diagnosing laryngopharyngeal reflux (LPR) in clinic. Study Design: Prospective case series. Methods: Biopsy specimens from interarytenoid LPR patients (seven acid and eight nonacid LPR) 21 sex‐ age‐matched normal controls were obtained IHC staining. The diagnosis was based on 24‐hour combined multichannel intraluminal esophageal impedance...

We evaluate the efficacy of concomitant therapy for Helicobacter pylori infection and associated factors that influence it in China, where has not previously been investigated. In this prospective study, 374 consecutive patients with H. were randomly assigned to 10 day regimens different proton pump inhibitors: esomeprazole (20 mg)/omeprazole mg), amoxicillin (1000 clarithromycin (500 mg) metronidazole (400 mg). All drugs administered twice daily. A [13C]urea breath test was performed at...

Background: Studies have shown that both NOX4 and RhoA play an important role in fibrosis they regulate each other. In lung fibrosis, NOX4/ROS is upstream molecule of the RhoA/ROCK1 signalling pathway, two molecules are opposite renal fibrosis. At present, no reports indicated whether above similar or other regulatory mechanisms exist liver Objectives: To investigate effects pathways on behaviour HSC-T6 cells their interaction mechanisms, as well effect UA to elucidate reduction hepatic...

To explore the natural history of covert hepatic encephalopathy (CHE) in absence medication intervention.

Accumulating studies have highlighted the biological significance of immunogenic cell death (ICD) in cancer immunity. However, influence ICD on tumor microenvironment (TME) formation and immune response Hepatocellular carcinoma (HCC) remains largely unexplored. In this study, we systematically analyzed mRNA profiles ICD-related genes 1847 HCC patients identified three molecular subtypes with significantly different features prognostic stratification. A reliable risk model named score was...

To determine the optimal dexmedetomidine dose for hemodynamic stability and recovery quality in modified electroconvulsive therapy (MECT). In this randomized trial, 252 patients receiving MECT were allocated to six groups (placebo, D1-D5; 42/group). Groups D1-D5 received (0.2-1.0 μg/kg) 10 min pre-anesthesia, while controls saline. Hemodynamic parameters heart rate (HR), mean arterial pressure (MAP), seizure duration, propofol requirements, times, adverse events analyzed. Doses ≥ 0.4 μg/kg...

Abstract IL-25 or IL-17E is a member of IL-17 cytokine family and has immune-modulating activities. The role in maintaining lipid metabolic homeostasis remains unknown. We investigated the effects exogenous deficiency on hepatic accumulation. expression was examined paraffin-embedded tissue sections liver from patients livers mice. Mouse model steatosis induced by feeding high-fat diet (HFD). Extent as well cytokines, key enzymes for pathways, markers Kupffer cells/macrophages, droplet (LD)...

Oxidative stress mediated by nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) plays an important role in intestinal mucosal barrier damage various disease states. Recent evidence suggests that and dysbiosis occur mice with hepatic fibrosis induced CCl4 or bile duct ligation. Another study showed ursolic acid (UA) attenuates experimental colitis via its anti-inflammatory antioxidant activities. The goal of this was to investigate the effects UA on CCl4-induced rats identify...

Hepatocellular carcinoma (HCC) is the third-most deadly cancer worldwide. More breakthroughs are needed in clinical practice for liver needed, and new treatment strategies required. This study aims to determine significant differences genes associated with LIHC further analyze its prognostic value further.Here, we used TCGA-LIHC database profiles of GSE25097 from GEO explore differentially co-expressed HCC tissues compared paratumor (or healthy) tissues. Then, utilized WGCNA screen genes....

OBJECTIVES: We sought to investigate the prevalence of clinically significant endoscopic findings (CSEFs) in Chinese patients presenting with uninvestigated typical reflux symptoms absence alarm symptoms, and evaluate whether prompt endoscopy is an appropriate initial management these patients. METHODS: Consecutive (i.e., heartburn or acid regurgitation) as chief complaints were recruited for symptom evaluation upper endoscopy, followed by a 2-week proton pump inhibitor (PPI) therapy....

Infection with parasitic nematodes, especially gastrointestinal geohelminths, affects hundreds of millions people worldwide and thus poses a major risk to global health. The host mechanism defense against enteric nematode infection remains be fully understood, but it involves polarized type 2 immunity leading alterations in intestinal function that facilitate worm expulsion. We investigated the role interleukin-25 (IL-25) protection Heligmosomoides polygyrus bakeri mice. Our results showed...

IL-25 is emerging as a key regulator of inflammation in the intestinal mucosa because its ability to promote type 2 while suppressing Th1 and Th17 responses. Several previous studies reported inconsistent results on role exogenous development colonic none were performed animals with genetic deletion IL-25. We investigated contribution endogenous DSS-induced colitis using mice deficient Mice exposed DSS drinking water ad libitum either for seven days (acute) or three cycles followed by 14...

Liver fibrosis often appears in chronic liver disease, with extracellular matrix (ECM) deposition as the main feature. Due to presence of liver-gut axis, destruction intestinal homeostasis is accompanied by development fibrosis. The inconsistent ecological environment different sites may lead differences microbiota. traditional Chinese medicine ursolic acid (UA) has been proven protect from We investigated changes microbiota parts intestine during and effect UA on these based high-throughput...

Activation of quiescent hepatic stellate cells (q‑HSCs) and their transformation to myofibroblasts (MFBs) is a key event in liver fibrosis. Hedgehog (Hh) signaling stimulates q‑HSCs differentiate into MFBs, NADPH oxidase (NOX) may be involved regulating Hh signaling. The author's preliminary study demonstrated that ursolic acid (UA) selectively induces apoptosis activated HSCs inhibits proliferation vitro via negative regulation NOX activity expression. However, the effect UA on remains...

There is no study verifying the predictive value of model for end-stage liver disease and sodium (MELD-Na) rebleeding its associated mortality in cirrhotic patients after cessation acute esophageal variceal hemorrhage (AVH) by endoscopic therapy. This aimed to determine MELD-Na comparing with MELD or Child-Turcotte-Pugh (CTP) scores.Consecutive adult AVH therapy (endoscopic ligation sclerotherapy injections) within 48 hours admission admitted from 2003 2012 were analyzed. The clinical...

Abstract Metastasis is crucial for the prognosis of hepatocellular carcinoma (HCC). Distinguishing potential risk factors distant metastasis in small HCC (diameter ≤ 5 cm) great significance improving prognosis. patients Surveillance, Epidemiology and End Results (SEER) registry with tumors cm diameter between January 2010 December 2015 were retrieved. Demographic clinicopathological metrics extracted, including age, sex, race, marital status, tumor size, histological grade, T stage, N M...