A5101624787- Optical Imaging and Spectroscopy Techniques
- Photoacoustic and Ultrasonic Imaging
- Infrared Thermography in Medicine
- Neuroscience and Neural Engineering
- Spectroscopy Techniques in Biomedical and Chemical Research
- Neurological disorders and treatments
- Neural dynamics and brain function
- Thermoregulation and physiological responses
- Head and Neck Cancer Studies
- EEG and Brain-Computer Interfaces
- Digital Radiography and Breast Imaging
- Parkinson's Disease Mechanisms and Treatments
- Advanced MRI Techniques and Applications
- MRI in cancer diagnosis
- Acupuncture Treatment Research Studies
- Climate Change and Health Impacts
- Ultrasound Imaging and Elastography
- Transcranial Magnetic Stimulation Studies
- Spectroscopy and Chemometric Analyses
- Non-Invasive Vital Sign Monitoring
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Functional Brain Connectivity Studies
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Research Studies
- Hemodynamic Monitoring and Therapy
Athinoula A. Martinos Center for Biomedical Imaging
2015-2025
Massachusetts General Hospital
2015-2025
Harvard University
2015-2025
Syracuse University
2009-2024
Wuzhou Red Cross Hospital
2005-2024
Tianjin University
2014-2024
Sun Yat-sen University
2024
Fifth Affiliated Hospital of Sun Yat-sen University
2024
Weatherford College
2024
Chinese PLA General Hospital
2024
<h3>Importance</h3> Concurrent chemoradiotherapy has been the standard treatment for stage II nasopharyngeal carcinoma (NPC) based on data using 2-dimensional conventional radiotherapy. There is limited evidence role of chemotherapy with use intensity-modulated radiation therapy (IMRT). <h3>Objective</h3> To assess whether concurrent can be safely omitted patients low-risk II/T3N0 NPC treated IMRT. <h3>Design, Setting, and Participants</h3> This multicenter, open-label, randomized, phase 3,...
We report a wide-field compressive diffuse optical tomography (DOT) system – mammography co-imager (OMCI) which aims to augment tens of thousands existing x-ray or tomosynthesis systems worldwide by adding functional assessment breast tissue and improve cancer diagnosis. The OMCI utilizes large field-of-view structured light illumination single-pixel-camera based detection techniques produce ultra-high spatial sampling density while ensuring that the inverse problem remains compact via...
We characterize cerebral sensitivity across the entire adult human head for diffuse correlation spectroscopy, an optical technique increasingly used bedside perfusion monitoring. Sixteen subject-specific magnetic resonance imaging-derived models were to identify high regions by running Monte Carlo light propagation simulations at over eight hundred uniformly distributed locations on head. Significant spatial variations in sensitivity, consistent subjects, found. also identified correlates of...
Significance: Contamination of diffuse correlation spectroscopy (DCS) measurements cerebral blood flow (CBF) due to systemic physiology remains a significant challenge in the clinical translation DCS for neuromonitoring. Tunable, multi-layer Monte Carlo-based (MC) light transport models have potential remove extracerebral cross-talk index ( CBFi ) estimates. Aim: We explore effectiveness MC recovering accurate changes presence strong variations during hypercapnia maneuver. Approach:...
Multi-spectral near-infrared diffuse optical tomography (DOT) is capable of providing functional tissue assessment that can complement structural mammographic images for more comprehensive breast cancer diagnosis.To take full advantage the readily available sub-millimeter resolution information in a multi-modal imaging setting, an efficient x-ray/optical joint image reconstruction model has been proposed previously to utilize anatomical from mammogram as prior.In this work, we develop...
Diffuse optical tomography (DOT) is emerging as a noninvasive functional imaging method for breast cancer diagnosis and neoadjuvant chemotherapy monitoring. In particular, the multimodal approach of combining DOT with x-ray digital tomosynthesis (DBT) especially synergistic DBT prior information can be used to enhance reconstruction. DOT, in turn, provides overlay onto mammographic images, increasing sensitivity specificity pathology. We describe dynamic apparatus designed tight integration...
Abstract: Chondrosarcoma is the second most common type of primary bone malignancy in United States after osteosarcoma. Surgical resections these tumors are only effective treatment to chondrosarcoma patients due their resistance conventional chemo- and radiotherapy. In this study, miR-125b was found perform its tumor-suppressor function inhibit glucose metabolism via direct targeting oncogene, ErbB2. We report downregulated both patient samples cell lines. The total 20 Asian showed...
Abstract The optimal post-treatment surveillance strategy that can detect early recurrence of a cancer within limited visits remains unexplored. Here we adopt nasopharyngeal carcinoma as the study model to establish an approach balances effectiveness disease detection versus costs. A total 7,043 newly-diagnosed patients are grouped according clinic-molecular risk grouping system. We use random survival forest simulate monthly probability recurrence, and thereby risk-based arrangements...
Near-infrared diffuse optical tomography (DOT) is a promising functional modality for breast cancer imaging; however, the clinical translation of DOT hampered by technical limitations. Specifically, conventional finite element method (FEM)-based image reconstruction approaches are time-consuming and ineffective in recovering full lesion contrast. To address this, we developed deep learning-based model (FDU-Net) comprised Fully connected subnet, followed convolutional encoder-Decoder U-Net...
Raman spectroscopy was used to study temporal molecular changes associated with spinal cord injury (SCI) in a rat model. spectra of saline-perfused, injured, and healthy cords were obtained compared. Two models, lateral hemisection moderate contusion investigated. The net fluorescence the showed clear differences between injured cords. Based on extensive histological biochemical characterization SCI available literature, these hypothesized be due cell death, demyelination, extracellular...
We characterize novel breast cancer imaging biomarkers for monitoring neoadjuvant chemotherapy (NACT) and predicting outcome.Specifically, we recruited 30 patients a pilot study in which NACT were imaged using dynamic tomographic optical (DTOBI) to quantify the hemodynamic changes due partial mammographic compression.DTOBI scans obtained pre-treatment (referred as day 0), well 7 days into therapy on female undergoing NACT.We present data 13 who participated both 0 measurements had evaluable...
We present instrumentation for probing of volar side fingertip capillary beds with free space coupled near infrared light while collecting Raman, Rayleigh, and Mie scattered as well fluorescence. Fingertip skin are highly vascularized relative to other tissues a desirable target noninvasive blood. But human hands fingers in particular also idiosyncratic body parts requiring specific apparatus allow careful methodical spectroscopic probing. The includes means precise reproducible placement...
To enable tissue function-based tumor diagnosis over the large number of existing digital mammography systems worldwide, we propose a cost-effective and robust approach to incorporate tomographic optical characterization with separately acquired mammograms. Using flexible contour-based registration algorithm, were able an independently measured two-dimensional x-ray mammogram as structural priors in joint optical/x-ray image reconstruction, resulting improved spatial details images property...
Near-infrared diffuse optical tomography (DOT) has the potential to improve accuracy of breast cancer diagnosis and aid in monitoring response tumors chemotherapy by providing hemoglobin-based functional imaging. The use structural lesion priors derived from clinical imaging methods, such as mammography, can recovery tumor contrast; however, accurate prior placement is essential take full advantage prior-guided DOT image reconstruction. Simultaneous anatomical may not always be possible or...
Probing tissue with near-infrared radiation (NIR) simultaneously produces remitted fluorescence and Raman scattering (IE) plus Rayleigh∕Mie light (EE) that noninvasively give chemical physical information about the materials objects within. We model as a three-phase system: plasma red blood cell (RBC) phases are mobile static phase. In vivo, any volume of naturally experiences spatial temporal fluctuations RBC content. Plasma fractions may be discriminated from each other on basis their...
Abstract Background Conditional survival (CS) provides dynamic prognostic estimates by considering the patients existing time. Since CS for endemic nasopharyngeal carcinoma (NPC) is lacking, we aimed to assess of NPC and establish a web‐based calculator predict individualized, conditional site‐specific recurrence risk. Methods Using an NPC‐specific database with big‐data intelligence platform, 10,058 non‐metastatic stage I–IVA receiving intensity‐modulated radiotherapy or without...
The optimal posttreatment surveillance strategy for nasopharyngeal carcinoma (NPC) remains unclear. Circulating cell-free Epstein-Barr virus (cfEBV) DNA has been recognized as a promising biomarker to facilitate early detection of NPC recurrence. Therefore, we aim determine whether integrating circulating cfEBV into follow-up is cost-effective.