A5048045488- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Intensive Care Unit Cognitive Disorders
- Neonatal and Maternal Infections
- Family Caregiving in Mental Illness
- Retinal and Optic Conditions
- Heparin-Induced Thrombocytopenia and Thrombosis
- SARS-CoV-2 and COVID-19 Research
- Bacterial Infections and Vaccines
- Peripheral Neuropathies and Disorders
- Cancer-related cognitive impairment studies
- Functional Brain Connectivity Studies
- Identity, Memory, and Therapy
- Neurobiology of Language and Bilingualism
- Neurological Disease Mechanisms and Treatments
- Autoimmune and Inflammatory Disorders
- Genomics and Rare Diseases
- Dermatological and COVID-19 studies
- Advanced Neuroimaging Techniques and Applications
- Diet and metabolism studies
- Dental Health and Care Utilization
- Autoimmune Bullous Skin Diseases
- Autoimmune Neurological Disorders and Treatments
National Neuroscience Institute
2016-2024
Tan Tock Seng Hospital
2016-2023
Duke-NUS Medical School
2023
Neurology, Inc
2022
National University of Singapore
2012
Acute ischemic stroke (AIS) is a known neurological complication in patients with respiratory symptoms of COVID-19 infection. However, AIS has not been described as late sequelae without COVID-19.To assess experienced by adults 50 years or younger the convalescent phase asymptomatic infection.This case series prospectively identified consecutive male who received care for from public health hospitals Singapore between May 21, 2020, and October 14, 2020. All these had laboratory-confirmed...
To describe the spectrum of COVID-19 neurology in Singapore.
<h3>Importance</h3> Reports of cerebral venous thrombosis (CVT) after messenger RNA (mRNA)-based SARS-CoV-2 vaccination has caused safety concerns, but CVT is also known to occur infection. Comparing the relative incidence infection vs may provide a better perspective this complication. <h3>Objective</h3> To compare rates and clinical characteristics following either or mRNA-based vaccines. <h3>Design, Setting, Participants</h3> Between January 23, 2020, August 3, 2021, observational cohort...
Cognitive assessment tools measure cognitive impairment and complement biomarkers to link symptoms with pathophysiological processes underlying dementia. However, language cultural differences in multilingual populations can influence the interpretation of when applied cross-cultural multinational studies. Areas covered: This article examines culture on Mini-Mental State Examination, Montreal Assessment, Alzheimer's Disease Assessment Scale-cognitive subscale, which are more commonly used...
Abstract Objective Frontotemporal dementia (FTD) encompasses a spectrum of neurodegenerative disorders, including behavioural variant FTD (bvFTD), semantic primary progressive aphasia (svPPA) and non‐fluent PPA (nfvPPA). While strong genetic component is implicated in FTD, Asia less frequently reported. We aimed to investigate the frequency Southeast Asian patients harbouring known variants. Methods A total 60 FTD‐spectrum (25 familial 35 sporadic) from Singapore Philippines were included....
Purpose: In 2015, an outbreak of group B streptococcal (GBS) infection caused by Streptococcus agalactiae Serotype III, multilocus sequence type 283, related to consuming infected raw freshwater fish, affected more than 200 patients in Singapore.We describe the clinical, laboratory, and neuroimaging features a subgroup adults with central nervous system (CNS) infections GBS. Materials Methods: The database Singapore Neurologic Infections Program (SNIP), national multicenter study for...
Abstract Background Southeast Asia represents 10% of the global population, yet little is known about regional clinical characteristics dementia and risk factors for progression. This study aims to describe clinico-demographic profiles in investigate association onset-type, education, cerebrovascular disease (CVD) on progression a real-world clinic setting. Methods In this longitudinal study, participants were consecutive series 1606 patients with from 2010 2019 tertiary memory Singapore....
Abstract Background Mild cognitive impairment (MCI) is a prodromal stage of Alzheimer’s disease that offers window for early intervention prior to dementia onset. The observed in MCI includes declines across several domains, including memory, processing speed, and executive function. Emerging evidence supports multidomain improve performance. Therefore, we aim investigate the utility novel, scalable multi‐domain digital as therapeutic solution prevent or reverse decline. Method 30 amnestic...
Neuropsychological assessments play a vital role in the early detection of cognitive disorders. However, lack Singapore-specific norms has resulted reliance on international, usually Western, that potentially reduce accuracy and reliability due to sociocultural differences.1 Moreover, longitudinal limits reliable monitoring changes over time.
The authors would like to make a correction in the publication of original article. “modified version Logical Memory (Immediate and Delayed Recall an adapted Story B)” is removed from Letter, due irreconcilable differences way test was administered across different research studies we drew data from, thus are not valid. respective Table 1 presented Letter has also been removed. correct table as follows. apologise for any inconvenience caused.
Background: Young-onset cognitive disorders (YOCD) often manifests with complex and atypical presentations due to underlying heterogenous pathologies. Therefore, a biomarker-based evaluation will allow for timely diagnosis definitive management. Objective: Here, we evaluated the safety usefulness of cerebrospinal fluid (CSF) sampling through lumbar puncture (LP) in YOCD patients tertiary clinical setting. Methods: Patients mild impairment (MCI) dementia age onset between 45-64 years were...
Abstract Background Mild Behavioural Impairment‐Checklist (MBI‐C) is a validated questionnaire that measures sustained later‐life emergent neuropsychiatric symptoms among people with prodromal dementia. Using this checklist as MBI case ascertainment instrument, the prevalence of was found to be 5.8% in subjective cognitive decline (SCD) and 14.2% mild impairment (MCI). While MBI‐C can self‐administered or administered through close informant via face‐to‐face phone interviews, it unknown...
OBJECTIVE To describe the clinical and initial neuroradiological manifestations of patients in an outbreak group B streptococcal (GBS) meningitis. BACKGROUND Since Dec 2014, many healthy non-pregnant adult with GBS infection were identified Singapore; was thought to be related consuming infected raw fish. DESIGN/METHODS The database Singapore Neurologic Infections Program (SNIP), a national multicentre study for surveillance infectious neurologic disease, reviewed select central nervous...
Abstract Background Mild cognitive impairment (MCI) is a prodromal stage of Alzheimer’s disease that offers window for early intervention prior to dementia onset. The observed in MCI includes declines across several domains, including memory, processing speed, and executive function. Emerging evidence supports multidomain improve performance. Therefore, we aim investigate the utility novel, scalable multi‐domain digital as therapeutic solution prevent or reverse decline. Method 30 amnestic...
Abstract Background Neuropsychiatric symptoms (NPS) are increasingly recognized as early non‐cognitive manifestations of patients at‐risk dementia and associated with accelerated cognitive decline. While stimulation may be an effective intervention in improving NPS quality life their caregivers, there is a need for digital that accessible scalable so the benefits behavioral outcomes can attained on larger scale. Here, we studied effectiveness novel multi‐domain among mild impairment (MCI)....
Abstract Background Neuropsychiatric symptoms (NPS) are increasingly recognized as early non‐cognitive manifestations of patients at‐risk dementia and associated with accelerated cognitive decline. While stimulation may be an effective intervention in improving NPS quality life their caregivers, there is a need for digital that accessible scalable so the benefits behavioral outcomes can attained on larger scale. Here, we studied effectiveness novel multi‐domain among mild impairment (MCI)....