A5088148584- Dementia and Cognitive Impairment Research
- Neurobiology of Language and Bilingualism
- Alzheimer's disease research and treatments
- Parkinson's Disease Mechanisms and Treatments
- Neurological Disease Mechanisms and Treatments
- Reading and Literacy Development
- Functional Brain Connectivity Studies
- Hearing Impairment and Communication
- Neurological and metabolic disorders
- Advanced Neuroimaging Techniques and Applications
- Long-Term Effects of COVID-19
- Neurological disorders and treatments
- Spatial Neglect and Hemispheric Dysfunction
- Art Therapy and Mental Health
- Cognitive Functions and Memory
- Folate and B Vitamins Research
- Cerebrovascular and Carotid Artery Diseases
- Neural dynamics and brain function
- Neurology and Historical Studies
- MRI in cancer diagnosis
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Genetic Neurodegenerative Diseases
- Disability Education and Employment
- Full-Duplex Wireless Communications
- Library Science and Information Literacy
National Neuroscience Institute
2016-2025
Singapore General Hospital
2015-2025
Tan Tock Seng Hospital
2023-2024
Duke-NUS Medical School
2016-2023
Changi General Hospital
2020-2021
Nanyang Technological University
2009-2020
Abstract Background Alzheimer’s disease (AD) and behavioral variant frontotemporal dementia (bvFTD) cause distinct atrophy functional disruptions within two major intrinsic brain networks, namely the default network salience network, respectively. It remains unclear if inter-network relationships whole-brain topology are also altered underpin cognitive social–emotional deficits. Methods In total, 111 participants (50 AD, 14 bvFTD, 47 age- gender-matched healthy controls) underwent...
In this paper, we consider a network consisting of one source, destination and two relays, under half duplex constraint. We analyze an amplify-and-forward (AF) two-path relaying scheme where the relays additionally performs inter-relay interference cancellation. With self cancellation, show that degradation in performance can be significantly reduced when channel gain increases. By treating AF as equivalent MIMO space time code, derive upper bound for pairwise error probability (PEP) system....
Undiagnosed cognitive impairment is a pervasive global issue, often due to subtle nature of early symptoms, necessitating the use brief tests for detection. However, most are not scalable (requiring trained professionals), and designed lower literacy groups (e.g. in underserved communities). Here, we developed PENSIEVE-AITM, drawing-based digital test that less dependent on literacy, can be self-administered <5 min. In prospective study involving 1758 community-dwelling individuals aged 65...
The association between cerebrovascular disease pathology (measured by white matter hyperintensities, WMH) and brain atrophy in early Alzheimer's (AD) remain to be elucidated. Thus, we investigated how WMH influence neurodegeneration cognition prodromal clinical AD. We examined 5 1 healthy controls, 35 subjects with mild cognitive impairment (MCI), 30 AD patients. tested total regional is related specific grey volume (GMV) reductions MCI compared controls. Stepwise regression analysis was...
<h3>Background</h3> Early diagnosis of cognitive impairment allows timely intervention with pharmacological and non-pharmacological measures. However, current evaluation tools do not cater for multilingual populations. <h3>Objective</h3> To develop validate a visual-based tool, the Visual Cognitive Assessment Test (VCAT), which can be administered to populations without need translation or adaptation. <h3>Method</h3> We designed battery tests evaluate domains memory, executive function,...
Early-onset dementia, presenting in individuals younger than 65 years, is a diagnosis with significant social and financial implications. The early-onset form of dementia Lewy bodies (DLB) poorly understood.To investigate clinical features that distinguish DLB (onset at age <65 years) from late-onset ≥65 Alzheimer disease (AD) dementia.This retrospective case-control study on patients pathologically confirmed or AD enrolled the National Alzheimer's Coordinating Center database January 2005...
Background: Alzheimer’s disease (AD) and behavioral variant frontotemporal dementia (bvFTD) show differential vulnerability to large-scale brain functional networks. Plasma neurofilament light (NfL), a promising biomarker of neurodegeneration, has been linked in AD patients glucose metabolism changes AD-related regions. However, it is unknown whether plasma NfL would be similarly associated with disease-specific connectivity bvFTD. Objective: Our study examined the associations between...
Mutations in PSEN1 are the most common cause of autosomal dominant familial Alzheimer's disease (FAD). We describe an African-American woman with a family history consistent FAD who began to experience cognitive decline at age 50. Her clinical p
Abstract Psychosis is common in Alzheimer’s disease (AD). However, studies on neuropathology vascular etiology contributing to psychosis AD lacking date. The aim of this study was investigate neuropathological related changes with psychosis. Data patients from the National Coordinating Center between 2005 September 2013 accessed and reviewed. Presence determined based Neuropsychiatric Inventory Questionnaire taken last visit within one year prior death were divided into positive negative...
Abstract Functional brain networks have preserved architectures in rest and task; nevertheless, previous work consistently demonstrated task-related functional reorganization. Efficient rest-to-task network reconfiguration is associated with better cognition young adults. However, aging cognitive load effects, as well contributions of intra- internetwork reconfiguration, remain unclear. We assessed age-related load-dependent effects on global network-specific between a spatial working memory...
Background: Non-amyloid mechanisms behind neurodegeneration and cognition impairment are unclear. Cerebrovascular disease (CVD) may play an important role in suspected non-Alzheimer’s pathophysiology (SNAP), especially Asia. Objective: To examine the association between CVD medial temporal lobe atrophy (MTA) amyloid-β negative patients with mild amnestic type dementia. Methods: Thirty-six dementia complete neuropsychological, cerebrospinal fluid (CSF) biomarker, neuroimaging information were...
Reading disorder is a recognized feature in primary progressive aphasia (PPA). Surface dyslexia, characterized by regularization errors, typically seen the English-speaking semantic variant of PPA (svPPA). However, dyslexic characteristics other languages, particularly logographical languages such as Chinese, remain sparse literature. This study aims to characterize and describe pattern this group patients comparing an svPPA with Chinese-speaking group. The authors hypothesized that...
Background and Purpose: A third of stroke patients suffer from post-stroke cognitive decline, depressive symptoms, anxiety symptoms. B-vitamin supplementation provides a possible safe affordable treatment to mitigate neuropsychiatric sequelae via reducing homocysteine levels. Our study aims examine the effect in prevention secondary were investigate associations between baseline factors three outcomes. Methods: Patients recruited as part Singaporean substudy randomized controlled trial that...
Number processing disorder is an acquired deficit in mathematical skills commonly observed Alzheimer's disease (AD), usually as a consequence of neurological dysfunction. Common impairments include syntactic errors (800012 instead 8012) and intrusion (8 thousand 12 eight twelve) number transcoding tasks. This study aimed to understand the characterization AD-related within alphabetic language (English) ideographical (Chinese), investigate differences between ideographic processing....
This article describes the mediated American Sing Language (ASL) presentation of technical vocabulary and definitions within context a web-based astronomy course for first year students at National Technical Institute Deaf Rochester Technology (Rochester, NY). showed achievement gains with fewer misconceptions. Also, student ratings instructor ASL skill, as reported on rating system, were higher after used videos.