A5044867102- Pancreatic function and diabetes
- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Endoplasmic Reticulum Stress and Disease
- Advanced biosensing and bioanalysis techniques
- Barrier Structure and Function Studies
- Advanced Glycation End Products research
- Diabetes and associated disorders
- Angiogenesis and VEGF in Cancer
- Diabetes Management and Research
- Cell Adhesion Molecules Research
- Neurological Disease Mechanisms and Treatments
- Mosquito-borne diseases and control
- Drug Transport and Resistance Mechanisms
- Pluripotent Stem Cells Research
- Complement system in diseases
- Malaria Research and Control
- Chronic Kidney Disease and Diabetes
- Cancer, Hypoxia, and Metabolism
- Organ Transplantation Techniques and Outcomes
- Immune Response and Inflammation
- Antifungal resistance and susceptibility
- Traditional Chinese Medicine Analysis
- Liver Disease and Transplantation
- Cancer Cells and Metastasis
China-Japan Friendship Hospital
2009-2018
Chinese Academy of Medical Sciences & Peking Union Medical College
2007-2018
Peking Union Medical College Hospital
2008-2018
Peking University
2009-2016
Sichuan University
2013
West China Second University Hospital of Sichuan University
2013
Cancer Hospital of Chinese Academy of Medical Sciences
2007
University of Geneva
1993-2002
University Hospital of Geneva
1996-2002
University Hospital and Clinics
1996
Chemotherapy of brain tumors remains a big challenge owing to the low drug transport across blood-brain barrier (BBB), multidrug resistance (MDR), and poor penetration into tumor tissue. We developed novel dual-targeting liposomal carrier that enabled BBB then target tumor. In carrier, tamoxifen (TAM) was incorporated lipid bilayer membrane liposomes wheat germ agglutinin (WGA) conjugated liposomes' surface. Topotecan loaded above liposomes. vitro, topotecan modified with TAM WGA were...
We exploited the ability of lentiviral vectors to govern stable transduction cells irrespective their cycling status induce reversible immortalization human primary cells. First, bicistronic HIV-derived expressing GFP− and HSV1 thymidine kinase containing LoxP sequence in LTR (HLox) were used transduce HeLa Cre expression led efficient proviral deletion, unexcised could be eliminated by ganciclovir treatment. A liver biopsy was then exposed a combination HLox that harbored either SV40 large...
Background. A series of 13 islet autotransplantations and allotransplantations performed between 1992 1999 at the University Hospital Geneva are presented. Factors affecting outcome analyzed. Methods. Islet autotransplantation has been in seven patients with chronic pancreatitis six benign tumors undergoing extensive pancreatectomy. allografts were C-peptide–negative simultaneously or after a kidney lung transplantation. Each recipient received islets from one to four donors. Panel-reactive...
Ligand-mediated brain-targeting drug delivery is one of the focuses at present. Elucidation exact targeting mechanisms serves to efficiently design these systems. In our previous studies, lactoferrin (Lf) was successfully exploited as a ligand modify cationic dendrimer-based nanoparticles (NPs). The Lf-modified NPs brain were systematically investigated in this study for first time. uptake vectors and by capillary endothelial cells (BCECs) related clathrin-dependent endocytosis,...
The choline transporter (ChT) is used to transporte choline-derivate-modified nanoparticles across the blood-brain barrier. It demonstrated that ChT an ideal Trojan horse. exhibit higher permeability brain capillary endothelial cells (BCECs) monolayer in vitro and gene distribution expression vivo. Detailed facts of importance specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made available submitted by authors....
// Xue-Tao Li 1,2 , Rui-Jun Ju 1 Xiu-Ying Fan Zeng Ji-Feng Shi Lei Liu Cheng-Xiang Zhang Meng-Ge Sun Jin-Ning Lou 3 and Wan-Liang Lu State Key Laboratory of Natural Biomimetic Drugs, School Pharmaceutical Sciences, Peking University, Beijing, China 2 Pharmacy, Liaoning University Traditional Chinese Medicine, Dalian, Institute Clinical Medical Chia-Japan Friendship Hospital, The Ministry Health, Correspondence: Lu, email: Keywords : multifunctional targeting liposomes, wheat germ agglutinin,...