Zhihua Song

ORCID: 0000-0003-2299-722X
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About
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Research Areas
  • Plant Molecular Biology Research
  • Analytical chemistry methods development
  • Pluripotent Stem Cells Research
  • Analytical Chemistry and Chromatography
  • Adipose Tissue and Metabolism
  • Plant Gene Expression Analysis
  • Advanced biosensing and bioanalysis techniques
  • Microfluidic and Capillary Electrophoresis Applications
  • CRISPR and Genetic Engineering
  • Biosensors and Analytical Detection
  • Animal Nutrition and Physiology
  • Plant Reproductive Biology
  • Carbon and Quantum Dots Applications
  • Ginseng Biological Effects and Applications
  • Sirtuins and Resveratrol in Medicine
  • Effects of Environmental Stressors on Livestock
  • Plant Stress Responses and Tolerance
  • Plant biochemistry and biosynthesis
  • Molecular Sensors and Ion Detection
  • Plant-Microbe Interactions and Immunity
  • Luminescence and Fluorescent Materials
  • Cancer therapeutics and mechanisms
  • Drug Transport and Resistance Mechanisms
  • Aluminum toxicity and tolerance in plants and animals
  • Plant tissue culture and regeneration

Peking University
1993-2025

Henan University of Technology
2023-2025

Beijing Forestry University
2018-2025

Center for Life Sciences
2024-2025

Yantai University
2019-2024

Tsinghua University
2024

Xi'an Jiaotong University
2024

Anhui Science and Technology University
2023

Anhui University of Science and Technology
2023

Weatherford College
2023

The differentiation capacity of human embryonic stem cells (hESCs) holds great promise for therapeutic applications. We report a novel three-stage method to efficiently direct the into hepatic in serum-free medium. Human ESCs were first differentiated definitive endoderm by 3 days Activin A treatment. Next, presence fibroblast growth factor-4 and bone morphogenetic protein-2 culture medium 5 induced efficient from cells. Approximately 70% expressed marker albumin. After 10 further vitro...

10.1002/hep.21582 article EN Hepatology 2007-04-26

Abstract Melatonin improves plant resistance to multiple stresses by participating in the biosynthesis of metabolites. Flavonoids are an important family secondary metabolites and widely recognized be involved resistance; however, crosstalk between melatonin flavonoid is largely unknown. We found that pigeon pea (Cajanus cajan) salt, drought, heat were significantly enhanced pre-treatment with melatonin. Combined transcriptome LC-ESI-MS/MS metabolomics analyses showed induced enrichment...

10.1093/jxb/erac276 article EN Journal of Experimental Botany 2022-06-21

The essentially infinite expansion potential and pluripotency of human embryonic stem cells (hESCs) makes them attractive for cell-based therapeutics. In contrast to mouse (mESCs), hESCs normally undergo high rates spontaneous apoptosis differentiation, making difficult maintain in culture. Here we demonstrate that p53 protein accumulates apoptotic induced by agents damage DNA. However, despite the accumulation p53, it nevertheless fails activate transcription its target genes. This...

10.1074/jbc.m610464200 article EN cc-by Journal of Biological Chemistry 2006-12-20

The gastrointestinal tract is considered as one of the main target organs affected by heat stress. Phytogenic feed additives containing phenolics and flavonoids can improve resistance broilers to This study was conducted investigate effects dietary supplementation with enzymatically treated Artemisia annua (EA) on growth performance, intestinal morphology, digestive enzyme activities, immunity antioxidant capacity challenged One hundred forty-four 21-day-old male Arbor Acres were randomly...

10.3382/ps/pex312 article EN cc-by-nc-nd Poultry Science 2017-10-25

For non-model plants, functional characterization of genes is still hampered by lack efficient stable transformation procedures. Here, we report a simple, fast and technique with Agrobacterium rhizogenes for generating transgenic roots in living plants to facilitate studies vivo. We showed that injection A. into stems various plant species lead root generation, which can sustain growth after the original, non-transgenic were cut off. A system was established pigeon pea, major woody food...

10.1111/pbi.13101 article EN cc-by Plant Biotechnology Journal 2019-02-26

SUMMARY Calcineurin B‐like (CBL)‐interacting protein kinases (CIPKs) play a central role in Ca 2+ signalling and promote drought tolerance plants. The CIPK gene family pigeon pea ( Cajanus cajan L.), major food crop affected by drought, has not previously been characterised. Here, we identified 28 genes the genome. Five CcCIPK were strongly upregulated roots upon treatment selected for further characterisation. Overexpression of CcCIPK13 CcCIPK14 increased survival rates two‐ to three‐fold...

10.1111/tpj.15234 article EN The Plant Journal 2021-03-18

Stimuli-responsive hydrogels are flourishing; however, a multiresponsive luminescent hydrogel actuator in which the stimuli do not interfere with each other is still difficult to produce. Here, smart bilayer shape memory and reversible luminescence switch behaviors under co-stimulation of pH heating reported. Under alkaline condition, chitosan-containing layer generates physical microcrystals fix temporary while lanthanide emits bright luminescence. Upon acid treatment, recovers its original...

10.1021/acsami.1c02589 article EN ACS Applied Materials & Interfaces 2021-04-21

The derivation of hepatic progenitor cells from human embryonic stem (hES) is value both in the study early liver organogenesis and creation an unlimited source donor for hepatocyte transplantation therapy. Here, we report first time generation derived hES cells. Hepatic endoderm were generated by activating FGF BMP pathways then purified fluorescence activated cell sorting using a newly identified surface marker, N-cadherin. After co-culture with STO feeder cells, these yielded colonies,...

10.1371/journal.pone.0006468 article EN cc-by PLoS ONE 2009-07-30

This study was conducted to investigate the effects of oridonin (ORI) on growth performance and antioxidant capacity in broiler chickens that were repeatedly challenged with lipopolysaccharide (LPS). A total 384 one-day-old male Arbor Acre randomly assigned 8 treatments 6 replicate cages per treatment birds replicate. There 4 dietary treatments: control group (birds fed basal diet), ORI 50 group, 80 100 (the diet supplemented 50, 80, mg/kg oridonin, respectively). Broilers intraperitoneally...

10.3382/ps/pew161 article EN cc-by-nc-nd Poultry Science 2016-05-04

Molecular imprinting-based ratiometric fluorescence (MI-RFL) nanosensors receive increasing concerns in various fields such as food security, owing to high selectivity and sensitivity, nondestruction, convenience, visualization, etc. Herein, a ternary-emission MI-RFL nanosensor was facilely constructed by postimprinting mixing (PIM) red-emission molecularly imprinted polymers (r-MIPs) green MIPs (g-MIPs) for rapid visual detection of folic acid (FA) samples. The two fluorescent were prepared...

10.1021/acsanm.4c01058 article EN ACS Applied Nano Materials 2024-04-17

// Sheng-qi Wang 1 , Shi-ting Liu Bo-xin Zhao Fu-heng Yang Ya-tian Qian-ying Liang Ya-bin Sun 2 Yuan Zhi-hua Song Yun Cai Guo-feng Li Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China GCP Center, Correspondence to: Guo-Feng Li, e-mail: liguofeng_2010@126.com Keywords: tyrosine kinase inhibitor, afatinib, ovarian cancer, multidrug resistance, ABCB1 Received: March 12, 2015 Accepted: July 10, Published: 20, ABSTRACT ABCB1-mediated resistance (MDR)...

10.18632/oncotarget.4536 article EN Oncotarget 2015-07-20

An experiment was conducted to evaluate the effects of including enzymatically treated Artemisia annua L. (EA) in broiler diets on growth performance, meat quality, and oxidative stability breast thigh muscles. A total 256 one-d-old Arbor Acres chicks were randomly allotted into four groups with eight replicates birds each. Broilers offered basal diet supplemented 0.0, 0.5, 1.0, 1.5 g/kg EA during 42-d experiment, respectively. The ADG, ADFI, feed/gain ratio (F:G) measured at 42 d age....

10.3382/ps/pew307 article EN cc-by-nc-nd Poultry Science 2016-09-09
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